. "2"^^ . . "P\u0159irozen\u00E9 protil\u00E1tky t\u0159\u00EDdy IgM a C-reaktivn\u00ED protein jsou fylogeneticky star\u00E9 efektorov\u00E9 mechanismy vrozen\u00E9 imunitn\u00ED odpov\u011Bdi. Za fyziologick\u00FDch okolnost\u00ED se pod\u00EDlej\u00ED na odstra\u0148ov\u00E1n\u00ED apoptotick\u00FDch bun\u011Bk. P\u0159i napaden\u00ED organismu patogenn\u00EDmi bakteriemi vytv\u00E1\u0159ej\u00ED prvn\u00ED obrannou linii, kter\u00E1 odstra\u0148uje pronikaj\u00EDc\u00ED mikroorganismy z krevn\u00EDho ob\u011Bhu. V membr\u00E1n\u00E1ch apoptotick\u00FDch bun\u011Bk, v bun\u011B\u010Dn\u00FDch st\u011Bn\u00E1ch n\u011Bkter\u00FDch patogenn\u00EDch bakteri\u00ED a v modifikovan\u00FDch lipoproteinov\u00FDch \u010D\u00E1stic\u00EDch rozpozn\u00E1vaj\u00ED p\u0159irozen\u00E9 protil\u00E1tky i CRP shodnou vazebnou ligandu, kterou je molekula cholinfosf\u00E1tu. Ve vlastn\u00EDm organismu je cholinfosf\u00E1t skryt\u00FDm antigenn\u00EDm epitopem, k jeho\u017E zp\u0159\u00EDstupn\u011Bn\u00ED doch\u00E1z\u00ED v d\u016Fsledku oxidace membr\u00E1n apoptotick\u00FDch bun\u011Bk a \u010D\u00E1stic LDL. Genetickou dispozic\u00ED organismu a p\u016Fsoben\u00EDm nep\u0159\u00EDzniv\u00FDch faktor\u016F zevn\u00EDho prost\u0159ed\u00ED, mezi n\u011B\u017E lze po\u010D\u00EDtat i n\u011Bkter\u00E9 infek\u010Dn\u00ED nemoci, se tato p\u016Fvodn\u011B ochrann\u00E1 antiaterogenn\u00ED reakce m\u011Bn\u00ED v proaterogenn\u00ED proces." . "CZ - \u010Cesk\u00E1 republika" . "Natural IgM class antibody and C-reactive protein (CRP) are phylogenetically old effector mechanisms of innate immune response. Under physiological circumstances, they are involved in the removal of apoptotic cells. After invasion of the body by pathogenic bacteria, CRP and IgM class antibody mount the first line of defense removal the invading organisms from the circulation. In apoptotic cell membranes, in the cellular membranes of some pathogenic bacteria, and in modified lipoprotein particles, natural antibody and CRP recognize an identical biding ligand, which is the phosphorylcholine molecule. In the body, choline phosphate is an antigen epitope becoming available as a result of oxidation of apoptotic cell membranes and LDL particles. Through the genetic predisposition of the body and the action of external factors, which can include some infectious diseases, this originally antiatherogenic reaction turns into a proatherogenic process."@en . "1"^^ . . "555544" . . "46" . "P\u0159irozen\u00E9 protil\u00E1tky t\u0159\u00EDdy IgM a C-reaktivn\u00ED protein jsou fylogeneticky star\u00E9 efektorov\u00E9 mechanismy vrozen\u00E9 imunitn\u00ED odpov\u011Bdi. Za fyziologick\u00FDch okolnost\u00ED se pod\u00EDlej\u00ED na odstra\u0148ov\u00E1n\u00ED apoptotick\u00FDch bun\u011Bk. P\u0159i napaden\u00ED organismu patogenn\u00EDmi bakteriemi vytv\u00E1\u0159ej\u00ED prvn\u00ED obrannou linii, kter\u00E1 odstra\u0148uje pronikaj\u00EDc\u00ED mikroorganismy z krevn\u00EDho ob\u011Bhu. V membr\u00E1n\u00E1ch apoptotick\u00FDch bun\u011Bk, v bun\u011B\u010Dn\u00FDch st\u011Bn\u00E1ch n\u011Bkter\u00FDch patogenn\u00EDch bakteri\u00ED a v modifikovan\u00FDch lipoproteinov\u00FDch \u010D\u00E1stic\u00EDch rozpozn\u00E1vaj\u00ED p\u0159irozen\u00E9 protil\u00E1tky i CRP shodnou vazebnou ligandu, kterou je molekula cholinfosf\u00E1tu. Ve vlastn\u00EDm organismu je cholinfosf\u00E1t skryt\u00FDm antigenn\u00EDm epitopem, k jeho\u017E zp\u0159\u00EDstupn\u011Bn\u00ED doch\u00E1z\u00ED v d\u016Fsledku oxidace membr\u00E1n apoptotick\u00FDch bun\u011Bk a \u010D\u00E1stic LDL. Genetickou dispozic\u00ED organismu a p\u016Fsoben\u00EDm nep\u0159\u00EDzniv\u00FDch faktor\u016F zevn\u00EDho prost\u0159ed\u00ED, mezi n\u011B\u017E lze po\u010D\u00EDtat i n\u011Bkter\u00E9 infek\u010Dn\u00ED nemoci, se tato p\u016Fvodn\u011B ochrann\u00E1 antiaterogenn\u00ED reakce m\u011Bn\u00ED v proaterogenn\u00ED proces."@cs . . "Ateroskler\u00F3za a p\u0159irozen\u00E9 autoprotil\u00E1tky: 2. \u010D\u00E1st: p\u0159irozen\u00E9 autoprotil\u00E1tky a C-reaktivn\u00ED protein" . "10" . . . "Atherosclerosis; natural; autoantibody; Natural; antibodies; C-reactive; protein"@en . "Ateroskler\u00F3za a p\u0159irozen\u00E9 autoprotil\u00E1tky: 2. \u010D\u00E1st: p\u0159irozen\u00E9 autoprotil\u00E1tky a C-reaktivn\u00ED protein" . . "RIV/00216208:11150/04:00004709!RIV08-MSM-11150___" . "Ateroskler\u00F3za a p\u0159irozen\u00E9 autoprotil\u00E1tky: 2. \u010D\u00E1st: p\u0159irozen\u00E9 autoprotil\u00E1tky a C-reaktivn\u00ED protein"@cs . "484;491" . "Ateroskler\u00F3za a p\u0159irozen\u00E9 autoprotil\u00E1tky: 2. \u010D\u00E1st: p\u0159irozen\u00E9 autoprotil\u00E1tky a C-reaktivn\u00ED protein"@cs . "Cor et Vasa" . . . . . "11150" . "S" . . "Atherosclerosis and natural autoantibody. Part 2: Natural antibodies and C-reactive protein"@en . "8"^^ . "RIV/00216208:11150/04:00004709" . . . "0010-8650" . . "Krejsek, Jan" . . "Atherosclerosis and natural autoantibody. Part 2: Natural antibodies and C-reactive protein"@en . . "[EDE173A9690A]" .