. . "S" . "Polycyklick\u00E9 aromatick\u00E9 uhlovod\u00EDky (PAU) p\u0159edstavuj\u00ED v\u0161udyp\u0159\u00EDtomn\u00E9 environment\u00E1ln\u00ED polutanty. Jejich toxick\u00E9 \u00FA\u010Dinky se projevuj\u00ED p\u0159edev\u0161\u00EDm ve tk\u00E1n\u00EDch s vysokou proliferac\u00ED. Pro projev toxick\u00FDch \u00FA\u010Dink\u016F PAU na kostn\u00ED d\u0159e\u0148 je nezbytn\u00E9, aby byly do kostn\u00ED d\u0159en\u011B distribuov\u00E1ny ve sv\u00E9 prim\u00E1rn\u00ED podob\u011B a teprve zde biotransformov\u00E1ny na toxick\u00E9 metabolity. Kl\u00ED\u010Dovou \u00FAlohu p\u0159i biotransformaci PAU v kostn\u00ED d\u0159eni m\u00E1 pravd\u011Bpodobn\u011B CYP1B1, kter\u00FD je konstitutivn\u011B exprimov\u00E1n strom\u00E1ln\u00EDmi bu\u0148kami. Mezi nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED mechanismy zm\u011Bn struktury a funkce bun\u011Bk kostn\u00ED d\u0159en\u011B (po expozici PAU) \u0159ad\u00EDme reakce toxick\u00FDch metabolit\u016F, rozvoj oxidativn\u00EDho stresu a ovlivn\u011Bn\u00ED hladin nitrobun\u011B\u010Dn\u00E9ho v\u00E1pn\u00EDku. Konkr\u00E9tn\u00ED forma po\u0161kozen\u00ED kostn\u00ED d\u0159en\u011B expozic\u00ED PAU m\u016F\u017Ee m\u00EDt podobu patologick\u00E9 indukce apopt\u00F3zy nebo malign\u00ED transformace kmenov\u00FDch bun\u011Bk. Kostn\u00ED d\u0159e\u0148 je \u00FAst\u0159edn\u00EDm org\u00E1nem krvetvorby a m\u00EDstem produkce bun\u011Bk imunitn\u00EDho syst\u00E9mu. Jej\u00ED po\u0161kozen\u00ED m\u016F\u017Ee m\u00EDt proto z\u00E1sadn\u00ED zdravotn\u00ED v\u00FDznam pro organismus jako celek." . "3"^^ . . . "591194" . . "\u00DA\u010Dinky polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F na kostn\u00ED d\u0159e\u0148" . . "11150" . "The effect of Polycyclic aromatic hydrocarbons to bone marrow"@en . "Novosad, Jakub" . . "Acta Medica (Hradec Kr\u00E1lov\u00E9) Supplementum" . "5"^^ . "CZ - \u010Cesk\u00E1 republika" . "RIV/00216208:11150/04:00004691!RIV08-MSM-11150___" . . "Fiala, Zden\u011Bk" . . "Borsk\u00E1, Lenka" . . . "[485DCD43C5CA]" . . "The effect of Polycyclic aromatic hydrocarbons to bone marrow"@en . . . "effect; Polycyclic; aromatic; hydrocarbons; marrow"@en . "\u00DA\u010Dinky polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F na kostn\u00ED d\u0159e\u0148"@cs . "Polycyclic aromatic hydrocarbons (PAH) represent a group of ubiquitous environmental pollutants. Their toxic effects are demonstrated mainly in tissues with high proliferation. The direct distribution of PAH in non-metabolized form to bone marrow and their biotransformation at this site to the toxic metabolites is necessary for demonstration of their toxic effect here. CYP1B1 that is constitutive expressed by stromal cells plays probably the main role in biotransformation of PAH in bone marrow. Reactions of toxic metabolites, development of oxidative stress and interference with intracellular calcium are ranged between the most important mechanisms of structural and functional changes of bone marrow after exposure to PAH. Pathological induction of apoptosis and malignant transformation of stem cells represent the concrete forms of bone marrow damage, caused by exposure to PAH. The bone marrow constitutes the central organ of hematopoiesis and the sites of production of cells of immune system. Its dama"@en . "2" . "\u00DA\u010Dinky polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F na kostn\u00ED d\u0159e\u0148" . "\u00DA\u010Dinky polycyklick\u00FDch aromatick\u00FDch uhlovod\u00EDk\u016F na kostn\u00ED d\u0159e\u0148"@cs . "75;81" . "47" . . . . "Polycyklick\u00E9 aromatick\u00E9 uhlovod\u00EDky (PAU) p\u0159edstavuj\u00ED v\u0161udyp\u0159\u00EDtomn\u00E9 environment\u00E1ln\u00ED polutanty. Jejich toxick\u00E9 \u00FA\u010Dinky se projevuj\u00ED p\u0159edev\u0161\u00EDm ve tk\u00E1n\u00EDch s vysokou proliferac\u00ED. Pro projev toxick\u00FDch \u00FA\u010Dink\u016F PAU na kostn\u00ED d\u0159e\u0148 je nezbytn\u00E9, aby byly do kostn\u00ED d\u0159en\u011B distribuov\u00E1ny ve sv\u00E9 prim\u00E1rn\u00ED podob\u011B a teprve zde biotransformov\u00E1ny na toxick\u00E9 metabolity. Kl\u00ED\u010Dovou \u00FAlohu p\u0159i biotransformaci PAU v kostn\u00ED d\u0159eni m\u00E1 pravd\u011Bpodobn\u011B CYP1B1, kter\u00FD je konstitutivn\u011B exprimov\u00E1n strom\u00E1ln\u00EDmi bu\u0148kami. Mezi nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED mechanismy zm\u011Bn struktury a funkce bun\u011Bk kostn\u00ED d\u0159en\u011B (po expozici PAU) \u0159ad\u00EDme reakce toxick\u00FDch metabolit\u016F, rozvoj oxidativn\u00EDho stresu a ovlivn\u011Bn\u00ED hladin nitrobun\u011B\u010Dn\u00E9ho v\u00E1pn\u00EDku. Konkr\u00E9tn\u00ED forma po\u0161kozen\u00ED kostn\u00ED d\u0159en\u011B expozic\u00ED PAU m\u016F\u017Ee m\u00EDt podobu patologick\u00E9 indukce apopt\u00F3zy nebo malign\u00ED transformace kmenov\u00FDch bun\u011Bk. Kostn\u00ED d\u0159e\u0148 je \u00FAst\u0159edn\u00EDm org\u00E1nem krvetvorby a m\u00EDstem produkce bun\u011Bk imunitn\u00EDho syst\u00E9mu. Jej\u00ED po\u0161kozen\u00ED m\u016F\u017Ee m\u00EDt proto z\u00E1sadn\u00ED zdravotn\u00ED v\u00FDznam pro organismus jako celek."@cs . "1211-247X" . "7"^^ . "RIV/00216208:11150/04:00004691" . .