"The aim of this study was to detect and quantify changes in endothelial expression of P-selectin, VCAM-1, ICAM-1 and iNOS in the vessel wall after the short-term administration of simvastatin in a rabbit model of atherosclerosis. We conclude that simvastatin has beneficial effects on endothelial function by decreasing expression of P-selectin, ICAM-1 and iNOS in endothelial cells in the very early stages of atherogenesis."@en . "[67B2B3CCD5EF]" . . "changes; endothelial; expression; adhesion; molecules; vessel; after; short-term; administration; simvastatin; rabbit; model; atherosclerosis"@en . . . . "\u017D\u010F\u00E1nsk\u00FD, Petr" . . "The aim of this study was to detect and quantify changes in endothelial expression of P-selectin, VCAM-1, ICAM-1 and iNOS in the vessel wall after the short-term administration of simvastatin in a rabbit model of atherosclerosis. We conclude that simvastatin has beneficial effects on endothelial function by decreasing expression of P-selectin, ICAM-1 and iNOS in endothelial cells in the very early stages of atherogenesis." . . "11150" . . "The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis"@en . "Zm\u011Bny v expresi adhezn\u00EDch molekul a iNOS v endotelu c\u00E9vn\u00ED st\u011Bny po kr\u00E1tkodob\u00E9m pod\u00E1n\u00ED simvastatinu na kr\u00E1li\u010D\u00EDm modelu ateroskler\u00F3zy"@cs . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "0022-3573" . . . . . "RIV/00216208:11150/04:00004439" . "RIV/00216208:11150/04:00004439!RIV08-MSM-11150___" . . "7"^^ . "557314" . "P(GP304/03/P049), S, V, Z(MSM 111600002), Z(MSM 113200008)" . "Solichov\u00E1, Dagmar" . . "5"^^ . "2005" . . "Zm\u011Bny v expresi adhezn\u00EDch molekul a iNOS v endotelu c\u00E9vn\u00ED st\u011Bny po kr\u00E1tkodob\u00E9m pod\u00E1n\u00ED simvastatinu na kr\u00E1li\u010D\u00EDm modelu ateroskler\u00F3zy"@cs . . . "Bun\u011B\u010Dn\u00E9 adhezivn\u00ED molekuly P-selektin, VCAM-1 a ICAM-1 stejn\u011B tak jako vysok\u00E9 hladiny oxidu dusnat\u00E9ho (NO) produkovan\u00E9 inducibiln\u00ED NO synt\u00E1zou (iNOS) jsou spojeny s rozvojem ateroskler\u00F3zy. C\u00EDlem t\u00E9to studie byla detekce a kvantifikace zm\u011Bn v expresi P-selektinu , VCAM-1a ICAM-1 v endotelu a iNOS v c\u00E9vn\u00ED st\u011Bn\u011B po kr\u00E1tkodob\u00E9m pod\u00E1n\u00ED simvastatinu (inhibitor HMG-CoA redukt\u00E1zy) v kr\u00E1li\u010D\u00EDm modelu ateroskler\u00F3zy. Metody: 18 kr\u00E1l\u00EDk\u016F druhu New Zealand White bylo rozd\u011Bleno do 3 skupin. Jedna konzumovala aterogenn\u00ED dietu (0,4% cholesterolu) 8 t\u00FDdn\u016F, druh\u00E1 konzumovala aterogenn\u00ED dietu (0,4% cholesterolu) 6 t\u00FDdn\u016F se sou\u010Dasn\u00FDm pod\u00E1v\u00E1n\u00EDm simvastatinu (10 mg/kg) posledn\u00ED 2 t\u00FDdny. Biochemick\u00E9 anal\u00FDzy prok\u00E1zaly simvastatinem indukovan\u00E9 sn\u00ED\u017Een\u00ED cholesterolu VLDL, LDL a HDL ale ne triglycerid\u016F. Simvastatin d\u00E1le sni\u017Eoval expresi P-selektinu, ICAM-I a iNOS v oblouku aorty a kr\u010Dn\u00ED tepn\u011B. Simvastatin m\u00E1 tedy p\u0159\u00EDzniv\u00E9 \u00FA\u010Dinky na endoteli\u00E1ln\u00ED funkci prost\u0159ednictv\u00EDm sni\u017Eov\u00E1n\u00ED exprese uveden\u00FDch molekul na po\u010D\u00E1tku aterogeneze."@cs . . "The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis"@en . . . . "Journal of Pharmacy and Pharmacology" . "The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis" . . "197;203" . . "The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis" . "2"^^ . . . . "57" . . . . .