"Imunohistochemick\u00E1 detekce a kvantifikace minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED nemoci pomoc\u00ED protil\u00E1tky DBA.44 v trepanobiopsi\u00EDch pacient\u016F s vlasatobun\u011B\u010Dnou leukemi\u00ED"@cs . "U pacient\u016F s vlasatobun\u011B\u010Dnou leuk\u00E9mi\u00ED, l\u00E9\u010Den\u00FDch 2-chlorodeoxyadenosinem nebo 2-deoxycoformicinem, je dosahov\u00E1no velmi vysok\u00E9ho po\u010Dtu terapeutick\u00FDch odpov\u011Bd\u00ED. P\u0159i dosa\u017Een\u00ED kompletn\u00ED remise \u2013 minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED nemoci nelze prok\u00E1zat aktivitu onemocn\u011Bn\u00ED, splenomegalii a lymfadenopatii; doch\u00E1z\u00ED k normalizaci koncentrace hemoglobinu, po\u010Dtu granulocyt\u016F a krevn\u00EDch desti\u010Dek. Sou\u010Dasn\u011B nelze standardn\u00EDm barven\u00EDm prok\u00E1zat leukemick\u00E9 bu\u0148ky v perifern\u00ED krvi a v kostn\u00ED d\u0159eni. K jejich pr\u016Fkazu lze pou\u017E\u00EDt imunohistochemick\u00E9ho vy\u0161et\u0159en\u00ED pomoc\u00ED protil\u00E1tky DBA.44 na odv\u00E1pn\u011Bn\u00FDch trepanobiopsi\u00EDch. Pro detekci leukemick\u00FDch bun\u011Bk je nutn\u00E9 hodnotit sou\u010Dasn\u011B intenzitu imunohistochemick\u00E9 reakce a z\u00E1rove\u0148 morfologii vlasat\u00FDch bun\u011Bk. P\u0159i kvantifikaci leukemick\u00FDch bun\u011Bk je pou\u017E\u00EDv\u00E1na po\u010D\u00EDta\u010Dov\u00E1 anal\u00FDza obrazu LUCIA-M." . . . . "Immunohistochemical; Detection; Quantification; Minimal; Residual; Disease; Antibody; Trephine; Marrow; Biopsies; Patients; Hairy; Leukemia"@en . . "Imunohistochemick\u00E1 detekce a kvantifikace minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED nemoci pomoc\u00ED protil\u00E1tky DBA.44 v trepanobiopsi\u00EDch pacient\u016F s vlasatobun\u011B\u010Dnou leukemi\u00ED" . . . . "\u017D\u00E1k, Pavel" . "39" . "Immunohistochemical Detection and Quantification of Minimal Residual Disease with the Use of DBA.44 Antibody in Trephine Bone Marrow Biopsies of Patients with Hairy Cell Leukemia"@en . . "Imunohistochemick\u00E1 detekce a kvantifikace minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED nemoci pomoc\u00ED protil\u00E1tky DBA.44 v trepanobiopsi\u00EDch pacient\u016F s vlasatobun\u011B\u010Dnou leukemi\u00ED"@cs . "D\u011Bdi\u010D, Karel" . "Imunohistochemick\u00E1 detekce a kvantifikace minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED nemoci pomoc\u00ED protil\u00E1tky DBA.44 v trepanobiopsi\u00EDch pacient\u016F s vlasatobun\u011B\u010Dnou leukemi\u00ED" . . . "4" . . . . "11150" . "S" . . "1210-7875" . "RIV/00216208:11150/03:00004264" . . "2"^^ . . . "610027" . "3"^^ . "RIV/00216208:11150/03:00004264!RIV08-MSM-11150___" . . "CZ - \u010Cesk\u00E1 republika" . . . . "Immunohistochemical Detection and Quantification of Minimal Residual Disease with the Use of DBA.44 Antibody in Trephine Bone Marrow Biopsies of Patients with Hairy Cell Leukemia"@en . "2"^^ . . "Hairy cell leukemia patients treated with 2-chlorodeoxyadenosine or 2-deoxycoformicin achieve a very high number of therapeutic responses. After complete remission, i.e. minimal residual disease, we cannot demonstrate the disease activity, splenomegaly, or lymphadenopathy; moreover, there comes to normalization of hemoglobin concentration, leukocyte count, and platelet count. No leukemic cells in peripheral blood or bone marrow smears can be seen with the use of staining techniques. They can be demonstrated immunohistochemically in decalcified trephine bone marrow biopsies with the use of DBA.44 antibody together with their morphologic features. For quantification of leukemic cells we use LUCIA-M image analysis."@en . "175;177" . "U pacient\u016F s vlasatobun\u011B\u010Dnou leuk\u00E9mi\u00ED, l\u00E9\u010Den\u00FDch 2-chlorodeoxyadenosinem nebo 2-deoxycoformicinem, je dosahov\u00E1no velmi vysok\u00E9ho po\u010Dtu terapeutick\u00FDch odpov\u011Bd\u00ED. P\u0159i dosa\u017Een\u00ED kompletn\u00ED remise \u2013 minim\u00E1ln\u00ED rezidu\u00E1ln\u00ED nemoci nelze prok\u00E1zat aktivitu onemocn\u011Bn\u00ED, splenomegalii a lymfadenopatii; doch\u00E1z\u00ED k normalizaci koncentrace hemoglobinu, po\u010Dtu granulocyt\u016F a krevn\u00EDch desti\u010Dek. Sou\u010Dasn\u011B nelze standardn\u00EDm barven\u00EDm prok\u00E1zat leukemick\u00E9 bu\u0148ky v perifern\u00ED krvi a v kostn\u00ED d\u0159eni. K jejich pr\u016Fkazu lze pou\u017E\u00EDt imunohistochemick\u00E9ho vy\u0161et\u0159en\u00ED pomoc\u00ED protil\u00E1tky DBA.44 na odv\u00E1pn\u011Bn\u00FDch trepanobiopsi\u00EDch. Pro detekci leukemick\u00FDch bun\u011Bk je nutn\u00E9 hodnotit sou\u010Dasn\u011B intenzitu imunohistochemick\u00E9 reakce a z\u00E1rove\u0148 morfologii vlasat\u00FDch bun\u011Bk. P\u0159i kvantifikaci leukemick\u00FDch bun\u011Bk je pou\u017E\u00EDv\u00E1na po\u010D\u00EDta\u010Dov\u00E1 anal\u00FDza obrazu LUCIA-M."@cs . . "\u010Cesko-slovensk\u00E1 patologie a soudn\u00ED l\u00E9ka\u0159stv\u00ED" . "[0BEFEFD6361C]" . . .