"621947" . "Posti\u017Een\u00ED srdce p\u0159i karcinoidu" . . . "RIV/00216208:11150/03:00004225!RIV08-MSM-11150___" . "Posti\u017Een\u00ED srdce p\u0159i karcinoidu"@cs . . "Demonstrated are eight cases of carcinoid heart disease (7 females, 1 male; average age 63.4 y.). The primary tumor was localized in the ileum in 5, and in the cecal area in 3 patients, with liver metastases in each case. The characteristic heart lesion appears as an endocardial plaque composed of loose intercellular matrix with scattered smooth muscle cells, covered by an endothelial layer. The plaques are apposed on an otherwise normal valvular, or mural endocardium of the right heart. The resulting combined valvular lesions show a predominance o tricuspid incompetence, or of pulmonary stenosis. In one case with a widely patent foramen ovale there was involvement of left-heart valves in addition. Local effect of serotonin appears to play the main role in pathogenesis of the endocardial plaques."@en . "[95E1345A9013]" . "1210-7875" . "Carcinoid; Heart; Disease"@en . "Posti\u017Een\u00ED srdce p\u0159i generalizovan\u00E9m karcinoidu je demonstrov\u00E1no na 8 p\u0159\u00EDpadech (7 \u017Een, 1 mu\u017E, pr\u016Fm\u011Brn\u00FD v\u011Bk 63,4 r.). Prim\u00E1rn\u00ED n\u00E1dor byl 5kr\u00E1t v ileu a 3kr\u00E1t v oblasti c\u00E9ka; ve v\u0161ech p\u0159\u00EDpadech byl generalizov\u00E1n do jater. Charakteristickou l\u00E9z\u00ED jsou endokardi\u00E1ln\u00ED pl\u00E1ty, tvo\u0159en\u00E9 \u0159\u00EDdkou mezibun\u011B\u010Dnou hmotou s bu\u0148kami hladk\u00E9 svaloviny a kryt\u00E9 endotelem. Pl\u00E1ty nasedaj\u00ED na jinak norm\u00E1ln\u00ED chlopenn\u00ED \u010Di n\u00E1st\u011Bnn\u00FD endokard prav\u00E9ho srdce. Vznikl\u00E9 chlopenn\u00ED vady maj\u00ED charakter kombinovan\u00FD, s p\u0159evahou trikuspid\u00E1ln\u00ED insuficience, resp. pulmon\u00E1ln\u00ED sten\u00F3zy. V jednom p\u0159\u00EDpad\u011B se \u0161iroce otev\u0159en\u00FDm foramen ovale byly posti\u017Eeny i chlopn\u011B lev\u00E9ho srdce. V patogenezi endokardi\u00E1ln\u00EDch pl\u00E1t\u016F hraje z\u0159ejm\u011B hlavn\u00ED \u00FAlohu lok\u00E1ln\u00ED p\u016Fsoben\u00ED serotoninu." . "11150" . "2" . "4"^^ . . "55;58" . "Posti\u017Een\u00ED srdce p\u0159i karcinoidu" . "\u0160teiner, Ivo" . "CZ - \u010Cesk\u00E1 republika" . . "RIV/00216208:11150/03:00004225" . . . "39" . "Carcinoid Heart Disease"@en . "1"^^ . . "S" . "\u010Cesko-slovensk\u00E1 patologie a soudn\u00ED l\u00E9ka\u0159stv\u00ED" . "1"^^ . . "Carcinoid Heart Disease"@en . . "Posti\u017Een\u00ED srdce p\u0159i generalizovan\u00E9m karcinoidu je demonstrov\u00E1no na 8 p\u0159\u00EDpadech (7 \u017Een, 1 mu\u017E, pr\u016Fm\u011Brn\u00FD v\u011Bk 63,4 r.). Prim\u00E1rn\u00ED n\u00E1dor byl 5kr\u00E1t v ileu a 3kr\u00E1t v oblasti c\u00E9ka; ve v\u0161ech p\u0159\u00EDpadech byl generalizov\u00E1n do jater. Charakteristickou l\u00E9z\u00ED jsou endokardi\u00E1ln\u00ED pl\u00E1ty, tvo\u0159en\u00E9 \u0159\u00EDdkou mezibun\u011B\u010Dnou hmotou s bu\u0148kami hladk\u00E9 svaloviny a kryt\u00E9 endotelem. Pl\u00E1ty nasedaj\u00ED na jinak norm\u00E1ln\u00ED chlopenn\u00ED \u010Di n\u00E1st\u011Bnn\u00FD endokard prav\u00E9ho srdce. Vznikl\u00E9 chlopenn\u00ED vady maj\u00ED charakter kombinovan\u00FD, s p\u0159evahou trikuspid\u00E1ln\u00ED insuficience, resp. pulmon\u00E1ln\u00ED sten\u00F3zy. V jednom p\u0159\u00EDpad\u011B se \u0161iroce otev\u0159en\u00FDm foramen ovale byly posti\u017Eeny i chlopn\u011B lev\u00E9ho srdce. V patogenezi endokardi\u00E1ln\u00EDch pl\u00E1t\u016F hraje z\u0159ejm\u011B hlavn\u00ED \u00FAlohu lok\u00E1ln\u00ED p\u016Fsoben\u00ED serotoninu."@cs . . . "Posti\u017Een\u00ED srdce p\u0159i karcinoidu"@cs . . .