"4"^^ . . . . "Adamcov\u00E1, Michaela" . "salicylaldehyde isonicotinoyl hydrazone (SIH); iron chelator; rabbit; biochemistry; haematology; cardiovascular; histology"@en . "RIV/00216208:11150/03:00002106!RIV/2005/MSM/111505/N" . . "RIV/00216208:11150/03:00002106" . "A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits"@en . "The potential toxic effects of repeated administration of the SIH, partly dissolved in 10% Cremophor solution, on various biochemical, haematological and cardiovascular parameters, and on morphology of selected tissues were investigated in rabbits. SIH did not induced marked signs of toxicity. Only a few and mild changes in some biochemical and haematological parameters were found, but most of them were noted also in control saline and Cremophor groups. The morphological changes in the kidney were only mild. Also the cardiac function was not affected markedly. Therefore, the obtained results can be considered to be promising from the standpoint of possible clinical use of the SIH."@en . "Mazurov\u00E1, Yvona" . "Studie potencio\u00E1ln\u00EDho toxick\u00E9ho efektu po 10-ti t\u00FDdenn\u00EDm pod\u00E1v\u00E1n\u00ED nov\u00E9ho chelatoru \u017Eeleza salicylaldehyd isonicotinoyl hydrazonu (SIH) u kr\u00E1l\u00EDk\u016F"@cs . . . "Kaplanov\u00E1, Jana" . . "8"^^ . "Studie potencio\u00E1ln\u00EDho toxick\u00E9ho efektu po 10-ti t\u00FDdenn\u00EDm pod\u00E1v\u00E1n\u00ED nov\u00E9ho chelatoru \u017Eeleza salicylaldehyd isonicotinoyl hydrazonu (SIH) u kr\u00E1l\u00EDk\u016F"@cs . . . . "163;170" . . "Byl studov\u00E1n potenci\u00E1ln\u00ED toxick\u00FD efekt SIH, \u010D\u00E1ste\u010Dn\u011B rozpu\u0161t\u011Bn\u00E9ho v roztoku 10% Cremophoru, p\u0159i opakovan\u00E9m pod\u00E1n\u00ED kr\u00E1l\u00EDk\u016Fm z hlediska biochemick\u00FDch, hematologick\u00FDch a kardiovaskul\u00E1rn\u00EDch ukazatel\u016F a z hlediska morfologick\u00E9ho hodnocen\u00ED vybran\u00FDch tk\u00E1\u0148ov\u00FDch vzork\u016F. SIH nevyvolal \u017E\u00E1dn\u00E9 z\u0159eteln\u00E9 zn\u00E1mky toxicity. Byly nalezeny jen ojedin\u011Bl\u00E9 m\u00EDrn\u00E9 zm\u011Bny v n\u011Bkter\u00FDch biochemick\u00FDch a hematologick\u00FDch parametrech, kter\u00E9 se v\u0161ak vyskytly i ve skupin\u011B kontrol s fyziologick\u00FDm roztokem a s Cremophorem. Morfologick\u00E9 zm\u011Bny v ledvin\u011B byly tak\u00E9 jen m\u00EDrn\u00E9ho stupn\u011B. Ani srde\u010Dn\u00ED funkce nebyla z\u0159eteln\u011B ovlivn\u011Bna. Z\u00EDskan\u00E9 v\u00FDsledky mohou b\u00FDt proto pova\u017Eov\u00E1ny za slibn\u00E9 z hlediska p\u0159\u00EDpadn\u00E9ho vyu\u017Eit\u00ED SIHu pro klinick\u00E9 \u00FA\u010Dely."@cs . "1211-4286" . . . . "4" . . "597180" . "A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits" . "A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits" . . . . "46" . . "A study of potential toxic effects after repeated 10-week administration of a new iron chelator salicylaldehyde isonicotinoyl hydrazone (SIH) to rabbits"@en . "11150" . "P(GA305/03/1511), V, Z(MSM 111600002)" . "9"^^ . . "Ger\u0161l, Vladim\u00EDr" . . . "CZ - \u010Cesk\u00E1 republika" . . . "[C0FDE918ADD1]" . "Acta Medica (Hradec Kr\u00E1lov\u00E9)" . . "The potential toxic effects of repeated administration of the SIH, partly dissolved in 10% Cremophor solution, on various biochemical, haematological and cardiovascular parameters, and on morphology of selected tissues were investigated in rabbits. SIH did not induced marked signs of toxicity. Only a few and mild changes in some biochemical and haematological parameters were found, but most of them were noted also in control saline and Cremophor groups. The morphological changes in the kidney were only mild. Also the cardiac function was not affected markedly. Therefore, the obtained results can be considered to be promising from the standpoint of possible clinical use of the SIH." .