"Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer" . "irinotecan; colorectal cancer; lymphocytes subpopulations"@en . "46" . "Z(MSM 111500002)" . "11150" . . . . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "CD3+CD4+lymphocytopenia, a decrease in CD8+CD28+ and CD19+lymphocytes, increased expression of activation markers and CD14+CD16+monocytosis are present in a significant proportion of metastatic colorectal cancer patients. CPT-11-based therapy seems to ameliorate CD3+CD4+lymphocytopenia, possibly by neutralizing the immunosuppressive effects of uncontrolled tumor growth. These observation may be useful for the design of immunotherapy trials in metastatic colorectal cancer." . . "RIV/00216208:11150/02:00001072" . . . . "49" . "CD3+CD4+lymphocytopenia, a decrease in CD8+CD28+ and CD19+lymphocytes, increased expression of activation markers and CD14+CD16+monocytosis are present in a significant proportion of metastatic colorectal cancer patients. CPT-11-based therapy seems to ameliorate CD3+CD4+lymphocytopenia, possibly by neutralizing the immunosuppressive effects of uncontrolled tumor growth. These observation may be useful for the design of immunotherapy trials in metastatic colorectal cancer."@en . . "RIV/00216208:11150/02:00001072!RIV/2003/MSM/111503/N" . . . "644233" . "0172-6390" . "967;970" . "Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer"@en . . . . "1"^^ . "Hepato-Gastroenterology" . "3"^^ . . "Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer"@en . "Effect of irinotecan on phenotype of peripheral blood leukocyte populations in patients metastatic colorectal cancer" . . "3"^^ . "Melichar, Bohuslav" . "0"^^ . "[7CC423687EDC]" . "0"^^ .