"Resten\u00F3za, brachyterapie, remodelace - maj\u00ED n\u011Bco spole\u010Dn\u00E9ho?"@cs . "Restenosis, brachytherapy, remodeling - is there anything they have in common?"@en . . "In-stent restenosis continues to pose a substantial limitation to percutaneous revascularization procedures compared with surgical treatment. A number of agents have been tested, without major clinical success. Intensive research demonstrated a beneficialeffect of ionozing radiation on modulating in-stent restenosis. The mechanism of action of radiation is due to positive remodeling of the irradiated vessels, and not to a reduction in the amount of the plaque, as originally assumed. Despite the current optimism, a number of problems associated with this therapeutic modality have remained, such as %22candy wrapper%22, %22georgaphical miss%22 or late thrombosis, so it will not be until the results of ongoing randomized studies have been published taht any definite conclusion can be made. New approaches to the management and prevention of restenosis - chemical plaque lysis, factors affecting natural vascular remodeling, biodegradable stents."@en . . . . "2"^^ . "3"^^ . "0"^^ . "Restenosis, brachytherapy, remodeling - is there anything they have in common?"@en . . "\u010Cervinka, Pavel" . "0"^^ . . "11150" . "P(NA4786)" . "367;372" . . . . "in-stent restenosis; brachytherapy; remodeling; myofibroblast"@en . . "CZ - \u010Cesk\u00E1 republika" . "7" . "0010-8650" . "[BDDE36C95C6E]" . . "RIV/00216208:11150/01:00102151" . "Cor et Vasa" . "Resten\u00F3za, brachyterapie, remodelace - maj\u00ED n\u011Bco spole\u010Dn\u00E9ho?" . "43" . . "In-stent resten\u00F3za p\u0159edstavuje podstatnou limitaci perkut\u00E1nn\u00EDch revaskularizac\u00ED ve srovn\u00E1n\u00ED s chirurgickou l\u00E9\u010Dbou. V prevenci vzniku in-stent resten\u00F3zy byla bez v\u011Bt\u0161\u00EDho klinick\u00E9ho \u00FAsp\u011Bchu testov\u00E1na \u0159ada farmakologick\u00FDch p\u0159\u00EDpravk\u016F. Byly proto hled\u00E1ny dal\u0161\u00ED mo\u017Enosti ovlivn\u011Bn\u00ED restenotick\u00E9ho procesu. Intensivn\u00ED v\u00FDzkum prok\u00E1zal p\u0159\u00EDzniv\u00FD \u00FA\u010Dinek ionizuj\u00EDc\u00EDho z\u00E1\u0159en\u00ED. Mechanismus \u00FA\u010Dinku radiace je d\u00E1n pozitivn\u00ED remodelac\u00ED oz\u00E1\u0159en\u00FDch c\u00E9v, a ne sn\u00ED\u017Een\u00EDm mno\u017Estv\u00ED pl\u00E1tu, jak se p\u016Fvodn\u011B p\u0159edpokl\u00E1dalo. Navzdory optimismu z\u016Fst\u00E1v\u00E1 \u0159ada probl\u00E9m\u016F, kter\u00E9 s sebou tato l\u00E9\u010Dba p\u0159in\u00E1\u0161\u00ED, jako jsou %22candy wrapper%22, geographical miss%22 nebo pozdn\u00ED tromb\u00F3za. Definitivn\u00ED zhodnocen\u00ED p\u0159inesou a\u017E z\u00E1v\u011Bry pr\u00E1v\u011B prob\u00EDhaj\u00EDc\u00EDch randomizovan\u00FDch studi\u00ED. Na obzoru jsou i nov\u00E9 zp\u016Fsoby l\u00E9\u010Dby a prevence resten\u00F3zy. Nad\u011Bjn\u00E1 je chemick\u00E1 l\u00FDza pl\u00E1tu nebo faktory ovliv\u0148uj\u00EDc\u00ED p\u0159irozenou remodelaci c\u00E9v. Slibn\u00FD je i v\u00FDvoj biodegradabiln\u00EDch stent\u016F." . . . . "694644" . "6"^^ . "RIV/00216208:11150/01:00102151!RIV/2002/MZ0/111502/N" . "\u0160\u0165\u00E1sek, Josef" . "Resten\u00F3za, brachyterapie, remodelace - maj\u00ED n\u011Bco spole\u010Dn\u00E9ho?"@cs . . "Resten\u00F3za, brachyterapie, remodelace - maj\u00ED n\u011Bco spole\u010Dn\u00E9ho?" . .