"12"^^ . . "RIV/00216208:11140/14:10283644!RIV15-MSM-11140___" . "18" . . "Rotterova, Pavla" . "http://dx.doi.org/10.1016/j.anndiagpath.2014.10.002" . . . . "Spagnolo, Dominic" . . "Koko\u0161kov\u00E1, Bohuslava" . . . "000345196100007" . "t(6;11) renal cell carcinoma (RCC) has been recognized as a rare and mostly nonaggressive tumor (NAT). The criteria for distinguishing aggressive tumors (AT) from NATs are not well established. A total of 6 cases were selected for the study. Five cases of t(6;11) RCCs behaved nonaggressively, and 1 was carcinoma with aggressive behavior. The tumors were analyzed morphologically using immunohistochemistry and by molecular-genetic methods. The specimen of aggressive t(6;11) RCC was from a 77-year-old woman who died of the disease 2.5 months after diagnosis. The specimens of nonaggressive t(6;11) RCCs were from 3 women and 2 men whose ages range between 15 and 54 years. Follow-up was available in all cases (2.5 months-8 years). The tumor size ranged from 3 to 14 cm in nonaggressive t(6:11) RCC. In the aggressive carcinoma, the tumor size was 12 cm. All tumors (6/6) were well circumscribed. Aggressive t(6;11) RCC was widely necrotic. Six (100%) of 6 all tumors displayed a solid/alveolar architecture with occasional tubules and pseudorosettes. Pseudopapillary formations lined by bizarre polymorphic cells were found focally in the aggressive t(6;11) RCC case. Mitoses, though rare, were found as well. All cases (AT and NAT) were positive for HMB-45, Melan-A, Cathepsin K, and cytokeratins. CD117 positivity was seen in 4 of 5 NATs, as well as in the primary and metastatic lesions of the AT. mTOR was positive in 2 of 5 NATs and vimentin in 4 of 5 NATs. Vimentin was negative in the primary lesion of the AT, as well as in the metastasis found in the adrenal gland. Translocation t(6;11)(Alpha-TFEB) or TFEB break was detected in 4 of 5 NATs and in the AT case." . "Van\u011B\u010Dek, Tom\u00E1\u0161" . "Annals of Diagnostic Pathology" . . "Molecular biology; Immunohistochemistiy; Nonaggressive; Aggressive; Translocation renal cell carcinoma t(6:11); Kidney"@en . . "Kalusov\u00E1, Krist\u00FDna" . . . "7"^^ . . "Mart\u00EDnek, Petr" . "Djuricic, Slavisa" . "Vesel\u00E1, Pavla" . . "Vranic, Semir" . . . "6" . "1862" . . . "Hes, Ond\u0159ej" . "Peckov\u00E1, Kv\u011Btoslava" . . . . "11140" . "I, P(ED2.1.00/03.0076)" . "Pivovar\u010D\u00EDkov\u00E1, Krist\u00FDna" . "1092-9134" . . "Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature"@en . . . . . . "Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature" . "RIV/00216208:11140/14:10283644" . "Hora, Milan" . "Dubov\u00E1, Magdal\u00E9na" . "Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature"@en . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Daum, Ond\u0159ej" . "Aggressive and nonaggressive translocation t(6;11) renal cell carcinoma: comparative study of 6 cases and review of the literature" . "Brunelli, Matteo" . "19"^^ . "Michal, Michal" . "t(6;11) renal cell carcinoma (RCC) has been recognized as a rare and mostly nonaggressive tumor (NAT). The criteria for distinguishing aggressive tumors (AT) from NATs are not well established. A total of 6 cases were selected for the study. Five cases of t(6;11) RCCs behaved nonaggressively, and 1 was carcinoma with aggressive behavior. The tumors were analyzed morphologically using immunohistochemistry and by molecular-genetic methods. The specimen of aggressive t(6;11) RCC was from a 77-year-old woman who died of the disease 2.5 months after diagnosis. The specimens of nonaggressive t(6;11) RCCs were from 3 women and 2 men whose ages range between 15 and 54 years. Follow-up was available in all cases (2.5 months-8 years). The tumor size ranged from 3 to 14 cm in nonaggressive t(6:11) RCC. In the aggressive carcinoma, the tumor size was 12 cm. All tumors (6/6) were well circumscribed. Aggressive t(6;11) RCC was widely necrotic. Six (100%) of 6 all tumors displayed a solid/alveolar architecture with occasional tubules and pseudorosettes. Pseudopapillary formations lined by bizarre polymorphic cells were found focally in the aggressive t(6;11) RCC case. Mitoses, though rare, were found as well. All cases (AT and NAT) were positive for HMB-45, Melan-A, Cathepsin K, and cytokeratins. CD117 positivity was seen in 4 of 5 NATs, as well as in the primary and metastatic lesions of the AT. mTOR was positive in 2 of 5 NATs and vimentin in 4 of 5 NATs. Vimentin was negative in the primary lesion of the AT, as well as in the metastasis found in the adrenal gland. Translocation t(6;11)(Alpha-TFEB) or TFEB break was detected in 4 of 5 NATs and in the AT case."@en . "Bauleth, Kevin" . "Kuroda, Naoto" . . . . "10.1016/j.anndiagpath.2014.10.002" . "[31687AF09564]" .