. "11140" . "RIV/00216208:11140/14:10283147!RIV15-MSM-11140___" . . . "60" . . . "[F1B3474CC169]" . . . "3"^^ . "Perspektivn\u00ED p\u0159\u00EDstupy v l\u00E9\u010Db\u011B sepse zalo\u017Een\u00E9 na principu nov\u00FDch patogenetick\u00FDch poznatk\u016F"@cs . . "3"^^ . . . . . . . . "Danihel, Vojt\u011Bch" . "Perspektivn\u00ED p\u0159\u00EDstupy v l\u00E9\u010Db\u011B sepse zalo\u017Een\u00E9 na principu nov\u00FDch patogenetick\u00FDch poznatk\u016F" . "Mat\u011Bjovi\u010D, Martin" . "sepsis treatment; sepsis; pathogenesis; immunoppression; extracorporal purification methods"@en . . "5"^^ . "Hlavn\u00EDmi pil\u00ED\u0159i v l\u00E9\u010Db\u011B t\u011B\u017Ek\u00E9 sepse a septick\u00E9ho \u0161oku jsou promptn\u00ED a adekv\u00E1tn\u00ED hemodynamick\u00E1 resuscitace, c\u00EDlen\u00E1 antibiotick\u00E1 l\u00E9\u010Dba, odstran\u011Bn\u00ED nebo dren\u00E1\u017E zdroje infekce a podpora org\u00E1nov\u00FDch funkc\u00ED. Navzdory adekv\u00E1tn\u00ED l\u00E9\u010Db\u011B a technologicky vysp\u011Bl\u00FDm mo\u017Enostem org\u00E1nov\u00E9 podpory v\u0161ak mortalita sepse z\u016Fst\u00E1v\u00E1 nep\u0159im\u011B\u0159en\u011B vysok\u00E1. V\u00FDvoj podp\u016Frn\u00FDch tzv. anti-sepsis l\u00E9\u010Debn\u00FDch opat\u0159en\u00ED byl v\u0161ak dosud s v\u00EDce ne\u017E 30 negativn\u00EDmi klinick\u00FDmi studiemi ne\u00FAsp\u011B\u0161n\u00FD. Recentn\u00ED pokroky v pochopen\u00ED patofyziologie sepse nicm\u00E9n\u011B formulovaly patogenetick\u00E1 paradigmata umo\u017E\u0148uj\u00EDc\u00ED v\u00FDvoj nov\u00FDch l\u00E9\u010Debn\u00FDch koncept\u016F. Tento \u010Dl\u00E1nek stru\u010Dn\u011B diskutuje perspektivn\u00ED l\u00E9\u010Debn\u00E9 sm\u011Bry na principu nov\u00FDch poznatk\u016F patogeneze sepse a septick\u00E9ho \u0161oku."@cs . "Perspektivn\u00ED p\u0159\u00EDstupy v l\u00E9\u010Db\u011B sepse zalo\u017Een\u00E9 na principu nov\u00FDch patogenetick\u00FDch poznatk\u016F" . "CZ - \u010Cesk\u00E1 republika" . "The emerging pathogenesis- based strategies for treating sepsis"@en . "The cornerstones of therapy for sepsis and septic shock remain the prompt and adequate hemodynamic resuscitation, administration of antibiotics that target the patogen, removal or drainage of an infected source and organ support. Despite adequate treatment and advanced life-support, the mortality remains high. However, the development of adjunctive anti-sepsis therapies has been challenging, with more than 30 unsuccesful drug trials. Fortunately, recent advances in our understanding of the sepsis pathophysiology revealednew pathogenetic paradigms, and, thus, provided new exciting therapeutic concepts. In this review, we briefly discuss emerging pathogenesis- based strategies for treating severe sepsis and septic shock."@en . "The emerging pathogenesis- based strategies for treating sepsis"@en . "1" . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "Perspektivn\u00ED p\u0159\u00EDstupy v l\u00E9\u010Db\u011B sepse zalo\u017Een\u00E9 na principu nov\u00FDch patogenetick\u00FDch poznatk\u016F"@cs . . "RIV/00216208:11140/14:10283147" . "36291" . "Hlavn\u00EDmi pil\u00ED\u0159i v l\u00E9\u010Db\u011B t\u011B\u017Ek\u00E9 sepse a septick\u00E9ho \u0161oku jsou promptn\u00ED a adekv\u00E1tn\u00ED hemodynamick\u00E1 resuscitace, c\u00EDlen\u00E1 antibiotick\u00E1 l\u00E9\u010Dba, odstran\u011Bn\u00ED nebo dren\u00E1\u017E zdroje infekce a podpora org\u00E1nov\u00FDch funkc\u00ED. Navzdory adekv\u00E1tn\u00ED l\u00E9\u010Db\u011B a technologicky vysp\u011Bl\u00FDm mo\u017Enostem org\u00E1nov\u00E9 podpory v\u0161ak mortalita sepse z\u016Fst\u00E1v\u00E1 nep\u0159im\u011B\u0159en\u011B vysok\u00E1. V\u00FDvoj podp\u016Frn\u00FDch tzv. anti-sepsis l\u00E9\u010Debn\u00FDch opat\u0159en\u00ED byl v\u0161ak dosud s v\u00EDce ne\u017E 30 negativn\u00EDmi klinick\u00FDmi studiemi ne\u00FAsp\u011B\u0161n\u00FD. Recentn\u00ED pokroky v pochopen\u00ED patofyziologie sepse nicm\u00E9n\u011B formulovaly patogenetick\u00E1 paradigmata umo\u017E\u0148uj\u00EDc\u00ED v\u00FDvoj nov\u00FDch l\u00E9\u010Debn\u00FDch koncept\u016F. Tento \u010Dl\u00E1nek stru\u010Dn\u011B diskutuje perspektivn\u00ED l\u00E9\u010Debn\u00E9 sm\u011Bry na principu nov\u00FDch poznatk\u016F patogeneze sepse a septick\u00E9ho \u0161oku." . "Ledvinov\u00E1, Lenka" . . . "I, P(ED2.1.00/03.0076)" . "0042-773X" . .