"Kokavec, Milan" . "11140" . "I" . "Van\u011B\u010Dek, Tom\u00E1\u0161" . . . . . "The authors present two cases of Ewing-like sarcoma of the humerus and femur of a 12-year-old boy and a 28-year-old male, respectively. Identical morphology in both tumors consisted of multiple solid nests with a mosaic collection of small, round, uniform cells with clear cytoplasm and no apparent nuclear atypia. A monotonous structural arrangement, including both rich vascularity of bordering septae and significant admixtures of eosinophil leucocytes, resulted in a final organoid %22neuroendocrine-like%22 pattern. Immunohistochemistry revealed diffuse strong CD10, CD99 and CD138 positivity. Detailed molecular analysis in both tumors confirmed translocation t(20;22) resulting in an EWSR1-NFATc2 fusion gene. Additionally, this translocation was accompanied by amplification of the proximal part of the genes and surrounding areas. Clinically, both neoplasms behaved aggressively and they were primarily chemoresistant. Four years later, the patient with the lesion in the humerus developed a massive local recurrence with a disruption of osteosynthesis. The last follow-up disclosed suspicious metastatic deposits in the lung. The boy with the femoral tumor underwent a total femoral prosthesis and there are no signs of local or systemic recurrence after 11 months of follow-up. he authors discuss the taxonomic placement of these rare examples of Ewing-like sarcoma family in the light of new molecular iscoveries."@en . "Vesel\u00FD, Karel" . . "CZ - \u010Cesk\u00E1 republika" . "RIV/00216208:11140/14:10282682" . "5"^^ . "RIV/00216208:11140/14:10282682!RIV15-MSM-11140___" . "Kde kon\u010D\u00ED a za\u010D\u00EDn\u00E1 diagn\u00F3za Ewingova sarkomu - popis dvou neobvykl\u00FDch kostn\u00EDch n\u00E1dor\u016F s translokac\u00ED t(20;22) (EWSR1-NFATc2)"@cs . "Where does Ewing sarcoma end and begin - two cases oo unusual bone tumors with t(20;22)(EWSR1-NFATc2) alteration"@en . "Where does Ewing sarcoma end and begin - two cases oo unusual bone tumors with t(20;22)(EWSR1-NFATc2) alteration"@en . "Kinkor, Zden\u011Bk" . . . "Kde kon\u010D\u00ED a za\u010D\u00EDn\u00E1 diagn\u00F3za Ewingova sarkomu - popis dvou neobvykl\u00FDch kostn\u00EDch n\u00E1dor\u016F s translokac\u00ED t(20;22) (EWSR1-NFATc2)" . "1210-7875" . . . . "Popisov\u00E1ny jsou dva p\u0159\u00EDpady prim\u00E1rn\u00EDho %22Ewing-like%22 sarkomu ve femuru 12let\u00E9ho chlapce a humeru 28let\u00E9ho mu\u017Ee. Morfologie obou n\u00E1dor\u016F byla shodn\u00E1 a sest\u00E1vala ze solidn\u00EDch hn\u00EDzd mozaikovit\u011B uspo\u0159\u00E1dan\u00FDch, kulat\u00FDch bun\u011Bk se sv\u011Btlou cytoplazmou a pravideln\u00FDmi j\u00E1dry. V\u00FDsledn\u00E9 organoidn\u00ED uspo\u0159\u00E1d\u00E1n\u00ED, v\u010Detn\u011B bohat\u00E9 sept\u00E1ln\u00ED vaskularizace a v\u00FDznamn\u00E9 p\u0159\u00EDm\u011Bsi eozinofiln\u00EDch leukocyt\u016F, p\u0159ipom\u00EDnalo neuroendokrinn\u00ED tumor. Imunohistochemick\u00FDm vy\u0161et\u0159en\u00EDm byla zji\u0161t\u011Bna pozitivita antigen\u016F CD10, CD99, CD138. Molekul\u00E1rn\u00ED anal\u00FDza prok\u00E1zala u obou sarkom\u016F p\u0159\u00EDtomnost f\u00FAzn\u00EDho transkriptu EWSR1-NFATc2 vych\u00E1zej\u00EDc\u00ED z translokace t(20;22), je\u017E byla z\u00E1rove\u0148 doprov\u00E1zena amplifikac\u00ED \u010D\u00E1st\u00ED t\u011Bchto gen\u016F a jejich p\u0159ilehl\u00FDch oblast\u00ED. Oba n\u00E1dory se chovaly agres\u00EDvn\u011B a byly prim\u00E1rn\u011B chemorezistentn\u00ED. L\u00E9ze v humeru 4 roky po resekci rozs\u00E1hle m\u00EDstn\u011B recidivovala s rozpadem osteosynt\u00E9zy a v plic\u00EDch byly zji\u0161t\u011Bny suspektn\u00ED metast\u00E1zy. Tumor femuru byl definitivn\u011B \u0159e\u0161en tot\u00E1ln\u00ED femor\u00E1ln\u00ED endoprot\u00E9zou a hoch je po 11 m\u011Bs\u00EDc\u00EDch od stanoven\u00ED diagn\u00F3zy bez recidivy. Diskutov\u00E1no je taxonomick\u00E9 postaven\u00ED t\u011Bchto vz\u00E1cn\u00FDch l\u00E9z\u00ED v r\u00E1mci heterogenn\u00ED skupiny tzv. %22Ewing-like%22 sarkomu."@cs . . . "Kde kon\u010D\u00ED a za\u010D\u00EDn\u00E1 diagn\u00F3za Ewingova sarkomu - popis dvou neobvykl\u00FDch kostn\u00EDch n\u00E1dor\u016F s translokac\u00ED t(20;22) (EWSR1-NFATc2)"@cs . . . "\u0160vajdler, Mari\u00E1n" . "24129" . "\u010Cesko-slovensk\u00E1 patologie a Soudn\u00ED l\u00E9ka\u0159stv\u00ED" . "Popisov\u00E1ny jsou dva p\u0159\u00EDpady prim\u00E1rn\u00EDho %22Ewing-like%22 sarkomu ve femuru 12let\u00E9ho chlapce a humeru 28let\u00E9ho mu\u017Ee. Morfologie obou n\u00E1dor\u016F byla shodn\u00E1 a sest\u00E1vala ze solidn\u00EDch hn\u00EDzd mozaikovit\u011B uspo\u0159\u00E1dan\u00FDch, kulat\u00FDch bun\u011Bk se sv\u011Btlou cytoplazmou a pravideln\u00FDmi j\u00E1dry. V\u00FDsledn\u00E9 organoidn\u00ED uspo\u0159\u00E1d\u00E1n\u00ED, v\u010Detn\u011B bohat\u00E9 sept\u00E1ln\u00ED vaskularizace a v\u00FDznamn\u00E9 p\u0159\u00EDm\u011Bsi eozinofiln\u00EDch leukocyt\u016F, p\u0159ipom\u00EDnalo neuroendokrinn\u00ED tumor. Imunohistochemick\u00FDm vy\u0161et\u0159en\u00EDm byla zji\u0161t\u011Bna pozitivita antigen\u016F CD10, CD99, CD138. Molekul\u00E1rn\u00ED anal\u00FDza prok\u00E1zala u obou sarkom\u016F p\u0159\u00EDtomnost f\u00FAzn\u00EDho transkriptu EWSR1-NFATc2 vych\u00E1zej\u00EDc\u00ED z translokace t(20;22), je\u017E byla z\u00E1rove\u0148 doprov\u00E1zena amplifikac\u00ED \u010D\u00E1st\u00ED t\u011Bchto gen\u016F a jejich p\u0159ilehl\u00FDch oblast\u00ED. Oba n\u00E1dory se chovaly agres\u00EDvn\u011B a byly prim\u00E1rn\u011B chemorezistentn\u00ED. L\u00E9ze v humeru 4 roky po resekci rozs\u00E1hle m\u00EDstn\u011B recidivovala s rozpadem osteosynt\u00E9zy a v plic\u00EDch byly zji\u0161t\u011Bny suspektn\u00ED metast\u00E1zy. Tumor femuru byl definitivn\u011B \u0159e\u0161en tot\u00E1ln\u00ED femor\u00E1ln\u00ED endoprot\u00E9zou a hoch je po 11 m\u011Bs\u00EDc\u00EDch od stanoven\u00ED diagn\u00F3zy bez recidivy. Diskutov\u00E1no je taxonomick\u00E9 postaven\u00ED t\u011Bchto vz\u00E1cn\u00FDch l\u00E9z\u00ED v r\u00E1mci heterogenn\u00ED skupiny tzv. %22Ewing-like%22 sarkomu." . "Baxa, Jan" . . "7"^^ . "2" . "50" . "Kde kon\u010D\u00ED a za\u010D\u00EDn\u00E1 diagn\u00F3za Ewingova sarkomu - popis dvou neobvykl\u00FDch kostn\u00EDch n\u00E1dor\u016F s translokac\u00ED t(20;22) (EWSR1-NFATc2)" . . . . "Muken\u0161nabl, Petr" . . "[A2CC7F5724D4]" . "amplification; 22) (EWSR1-NFATc2); t(20; Ewing-like sarcoma; small blue round cell tumor; femur; humerus; bone"@en . . . . "4"^^ .