"Mal\u00FD, Marek" . . . "11140" . . "Panzner, Petr" . "Analyis of sensitization patterns of pollen allergic patients from West Bohemia region"@en . "Anal\u00FDza senzibiliza\u010Dn\u00EDch profil\u016F pylov\u00FDch alergik\u016F z oblasti z\u00E1padn\u00EDch \u010Cech"@cs . "RIV/00216208:11140/14:10282512" . . "2"^^ . . "Alergie" . "Vlas, Tom\u00E1\u0161" . "3120" . "CZ - \u010Cesk\u00E1 republika" . . "1212-3536" . "Molecular diagnosis of allergy is a modern approach which enables new insights into the sensitization profiles of allergic patients. Microarray technology provides detection of sensitization to a higher number of molecules in frame of one test. We used this tool in the sensitization analysis to pollen derived molecules in patients coming from our region. 1096 patients sensitized to at least one pollen derived molecule were included into the analysis. The most frequent sensitization rate (80.8%) was found to grass pollen derived molecules (Phl p 1 66.3%), the second most frequent (54.9%) was to betulaceae pollen derived molecules (Bet v 1 52.5%). Sensitization rates to cupressaceae and plane tree pollen derived molecules were observed unexpectedly frequently (in 14.0%, resp. 15.3%). Sensitization rates to other pollen derived molecules were in the expected ranges. Sensitizations to cross-reacting molecules (panallergens) were observed less frequently than reported from southern countries. Molecular diagnosis of allergy gives a more precise and comprehensive insight into the sensitization profile of a patient, allowing better understanding of the sensitization process, and the explored data may help to the optimization of allergen specific immunotherapy."@en . . "pollen allergens; sensitization; molecular diagnosis"@en . . "Analyis of sensitization patterns of pollen allergic patients from West Bohemia region"@en . "5"^^ . "Anal\u00FDza senzibiliza\u010Dn\u00EDch profil\u016F pylov\u00FDch alergik\u016F z oblasti z\u00E1padn\u00EDch \u010Cech"@cs . . "Molekul\u00E1rn\u00ED diagnostika alergie je modern\u00EDm p\u0159\u00EDstupem, kter\u00FD mimo jin\u00E9 umo\u017E\u0148uje nov\u00E9 pohledy na senzibiliza\u010Dn\u00ED profily alergik\u016F. Technologie microarray poskytuje mo\u017Enost detekce senzibilizace k v\u011Bt\u0161\u00EDmu spektru molekul v r\u00E1mci jednoho vy\u0161et\u0159en\u00ED. Tento p\u0159\u00EDstup jsme vyu\u017Eili p\u0159i anal\u00FDze senzibiliza\u010Dn\u00EDho spektra na pylov\u00E9 alergeny u pacient\u016F z oblasti z\u00E1padn\u00EDch \u010Cech. Bylo zhodnoceno 1096 pacient\u016F, kte\u0159\u00ED byli senzibilizov\u00E1ni alespo\u0148 na jednu molekulu odvozenou od pyl\u016F. Nej\u010Dast\u011Bji pozorovanou (v 80,8 %) byla senzibilizace na molekuly pyl\u016F trav (Phl p 1 66,3 %), druhou nej\u010Dast\u011Bj\u0161\u00ED (v 54,9 %) na molekuly pyl\u016F b\u0159\u00EDzovit\u00FDch strom\u016F (Bet v 1 52,5 %). Neo\u010Dek\u00E1van\u011B byly \u010Dasto zji\u0161\u0165ov\u00E1ny senzibilizace na molekuly odvozen\u00E9 od pyl\u016F cyp\u0159i\u0161ovit\u00FDch strom\u016F (v 14,0 %) a platanu (v 15,3 %). Frekvence dal\u0161\u00EDch senzibilizac\u00ED se pohybovaly v o\u010Dek\u00E1van\u00FDch mez\u00EDch. Frekvence senzibilizac\u00ED ke zk\u0159\u00ED\u017Een\u011B reaguj\u00EDc\u00EDm molekul\u00E1m (panalergen\u016Fm) byly zji\u0161\u0165ov\u00E1ny m\u00E9n\u011B \u010Dasto, ne\u017E ukazuj\u00ED data z ji\u017En\u00EDch zem\u00ED. Molekul\u00E1rn\u00ED diagnostika alergie d\u00E1v\u00E1 p\u0159esn\u011Bj\u0161\u00ED a komplexn\u011Bj\u0161\u00ED pohled na senzibiliza\u010Dn\u00ED profil pacienta, umo\u017E\u0148uje l\u00E9pe definovat proces senzibilizace a zji\u0161t\u011Bn\u00E9 \u00FAdaje mohou napomoci k optimalizaci l\u00E9\u010Dby alergenovou imunoterapi\u00ED." . "Molekul\u00E1rn\u00ED diagnostika alergie je modern\u00EDm p\u0159\u00EDstupem, kter\u00FD mimo jin\u00E9 umo\u017E\u0148uje nov\u00E9 pohledy na senzibiliza\u010Dn\u00ED profily alergik\u016F. Technologie microarray poskytuje mo\u017Enost detekce senzibilizace k v\u011Bt\u0161\u00EDmu spektru molekul v r\u00E1mci jednoho vy\u0161et\u0159en\u00ED. Tento p\u0159\u00EDstup jsme vyu\u017Eili p\u0159i anal\u00FDze senzibiliza\u010Dn\u00EDho spektra na pylov\u00E9 alergeny u pacient\u016F z oblasti z\u00E1padn\u00EDch \u010Cech. Bylo zhodnoceno 1096 pacient\u016F, kte\u0159\u00ED byli senzibilizov\u00E1ni alespo\u0148 na jednu molekulu odvozenou od pyl\u016F. Nej\u010Dast\u011Bji pozorovanou (v 80,8 %) byla senzibilizace na molekuly pyl\u016F trav (Phl p 1 66,3 %), druhou nej\u010Dast\u011Bj\u0161\u00ED (v 54,9 %) na molekuly pyl\u016F b\u0159\u00EDzovit\u00FDch strom\u016F (Bet v 1 52,5 %). Neo\u010Dek\u00E1van\u011B byly \u010Dasto zji\u0161\u0165ov\u00E1ny senzibilizace na molekuly odvozen\u00E9 od pyl\u016F cyp\u0159i\u0161ovit\u00FDch strom\u016F (v 14,0 %) a platanu (v 15,3 %). Frekvence dal\u0161\u00EDch senzibilizac\u00ED se pohybovaly v o\u010Dek\u00E1van\u00FDch mez\u00EDch. Frekvence senzibilizac\u00ED ke zk\u0159\u00ED\u017Een\u011B reaguj\u00EDc\u00EDm molekul\u00E1m (panalergen\u016Fm) byly zji\u0161\u0165ov\u00E1ny m\u00E9n\u011B \u010Dasto, ne\u017E ukazuj\u00ED data z ji\u017En\u00EDch zem\u00ED. Molekul\u00E1rn\u00ED diagnostika alergie d\u00E1v\u00E1 p\u0159esn\u011Bj\u0161\u00ED a komplexn\u011Bj\u0161\u00ED pohled na senzibiliza\u010Dn\u00ED profil pacienta, umo\u017E\u0148uje l\u00E9pe definovat proces senzibilizace a zji\u0161t\u011Bn\u00E9 \u00FAdaje mohou napomoci k optimalizaci l\u00E9\u010Dby alergenovou imunoterapi\u00ED."@cs . . . . "[8710C1B7D7F4]" . "Anal\u00FDza senzibiliza\u010Dn\u00EDch profil\u016F pylov\u00FDch alergik\u016F z oblasti z\u00E1padn\u00EDch \u010Cech" . . "Anal\u00FDza senzibiliza\u010Dn\u00EDch profil\u016F pylov\u00FDch alergik\u016F z oblasti z\u00E1padn\u00EDch \u010Cech" . . "Vachov\u00E1, Martina" . . "RIV/00216208:11140/14:10282512!RIV15-MSM-11140___" . "V\u00EDtovcov\u00E1, Petra" . "I" . "8"^^ . "4" . "16" .