. "48" . "Michal, Michal" . "4" . "CZ - \u010Cesk\u00E1 republika" . . . "1210-7875" . "\u010Cesko-slovensk\u00E1 patologie a Soudn\u00ED l\u00E9ka\u0159stv\u00ED" . . "Pleomorfn\u00ED adenom je nej\u010Dast\u011Bj\u0161\u00ED n\u00E1dor slinn\u00FDch \u017El\u00E1z, charakterizovan\u00FD komplexn\u00ED bif\u00E1zickou strukturou s plasticitou bun\u011Bk a \u010Dast\u00FDmi metapl\u00E1ziemi, kdy n\u011Bkter\u00E9 m\u00E9n\u011B obvykl\u00E9 n\u00E1lezy vzbuzuj\u00ED podez\u0159en\u00ED z malignity a jsou nez\u0159\u00EDdka p\u0159edm\u011Btem konzulta\u010Dn\u00EDch biopsi\u00ED. Intravaskul\u00E1rn\u00ED invaze n\u00E1dorov\u00FDch struktur je u v\u011Bt\u0161iny n\u00E1dor\u016F zn\u00E1mkou malignity, ale vz\u00E1cn\u011B v okraji zcela benign\u00EDho pleomorfn\u00EDho adenomu mohou dilatovan\u00E9 krevn\u00ED c\u00E9vy obsahovat %22metastatick\u00E1%22 n\u00E1dorov\u00E1 depozita. P\u0159i absenci jin\u00FDch suspektn\u00EDch morfologick\u00FDch zn\u00E1mek (nekr\u00F3zy, atypick\u00E9 mit\u00F3zy) by m\u011Bl b\u00FDt tento n\u00E1lez ignorov\u00E1n a v \u017E\u00E1dn\u00E9m p\u0159\u00EDpad\u011B by nem\u011Bl b\u00FDt hodnocen jako zvrat v karcinom. Pleomorfn\u00ED adenomy zvl\u00E1\u0161t\u011B mal\u00FDch slinn\u00FDch \u017El\u00E1z mohou obsahovat rozs\u00E1hl\u00E1 lo\u017Eiska skvam\u00F3zn\u00ED a mucin\u00F3zn\u00ED metaplazie napodobuj\u00EDc\u00ED mukoepidermoidn\u00ED karcinom. Absence invazivn\u00EDho r\u016Fstu a translokac\u00ED t(11;19) a t(11;15), a naopak p\u0159\u00EDtomnost chondromyxoidn\u00EDho stromatu potvrd\u00ED spr\u00E1vnou diagn\u00F3zu pleomorfn\u00EDho adenomu. Diagnostick\u00E9 \u00FAskal\u00ED d\u00E1le p\u0159edstavuj\u00ED lo\u017Eiska kribriformn\u00EDch struktur bud\u00EDc\u00ED podez\u0159en\u00ED z adenoidn\u011B cystick\u00E9ho karcinomu a onkocyt\u00E1rn\u00ED diferenciace s atypiemi, kter\u00E9 napodobuj\u00ED zvrat v karcinom. Nej\u010Dast\u011Bji konzultovan\u00E9 pleomorfn\u00ED adenomy jsou celul\u00E1rn\u00ED n\u00E1dory s lo\u017Eisky atypick\u00FDch bun\u011Bk, kter\u00E9 mohou odpov\u00EDdat inici\u00E1ln\u00EDmu zvratu v karcinom in situ, ale pouze atypie k diagn\u00F3ze malignity nesta\u010D\u00ED. Pro malignitu sv\u011Bd\u010D\u00ED vysok\u00FD MIB1 index, exprese HER-2/neu a v\u00FDrazn\u00E9 atypie v lumin\u00E1ln\u00ED dukt\u00E1ln\u00ED vrstv\u011B."@cs . "4"^^ . "158932" . . "Pleomorfn\u00ED adenom slinn\u00FDch \u017El\u00E1z: diagnostick\u00E1 \u00FAskal\u00ED a histologick\u00E9 n\u00E1lezy bud\u00EDc\u00ED podez\u0159en\u00ED z malignity"@cs . "4"^^ . "11140" . "RIV/00216208:11140/12:10124606!RIV13-MSM-11140___" . "Andrle, Pavel" . "I" . . . . . . "Pleomorphic adenoma is the most common salivary gland tumor, characterized by a complex biphasic proliferation of epithelial and myoepithelial cells intermingled with a mezenchymal component with frequent metaplastic changes and protean histomorphology of the cells. This review describes several unusual histological findings in pleomorphic adenoma that may mimic malignancy, and therefore they represent a diagnostic pitfall. Intravascular invasion of tumor cells is generally suspicious of malignancy; however, intravascular tumor deposits may be rarely found within the capsule of clinically benign salivary pleomorphic adenomas. It is important not to render a malignant diagnosis in such neoplasms, in the absence of other evidence of malignancy. Pleomorphic adenomas, particularly of minor glands of palate, may contain large areas of squamous and mucinous metaplasia suspicious of mucoepidermoid carcinoma (MEC). In contrast to MEC, metaplastic pleomorphic adenomas do not harbour the distinctive translocations t(11;19) and t(11;15), they are not invasive, in contrast they reveal at least focally myxochondroid stroma. Cribriform structures in pleomorphic adenoma may mimic adenoid cystic carcinoma. Oncocytic metaplasia in cellular rich pleomorphic adenoma/myoepithelioma may be associated with significant nuclear polymorphism and hyperchromasia suspicious of malignancy. The most common pitfall in diagnosis of pleomorphic adenoma is so called %22atypical PA%22 that must be distinguished from early malignant transformation to in situ-carcinoma ex pleomorphic adenoma. Keywords: salivary gland - pleomorphic adenoma - pitfall - metaplasia - intravascular tumor deposits - atypical - carcinoma ex pleomorphic adenoma."@en . . "5"^^ . . . . "Pleomorfn\u00ED adenom slinn\u00FDch \u017El\u00E1z: diagnostick\u00E1 \u00FAskal\u00ED a histologick\u00E9 n\u00E1lezy bud\u00EDc\u00ED podez\u0159en\u00ED z malignity" . "Pleomorfn\u00ED adenom je nej\u010Dast\u011Bj\u0161\u00ED n\u00E1dor slinn\u00FDch \u017El\u00E1z, charakterizovan\u00FD komplexn\u00ED bif\u00E1zickou strukturou s plasticitou bun\u011Bk a \u010Dast\u00FDmi metapl\u00E1ziemi, kdy n\u011Bkter\u00E9 m\u00E9n\u011B obvykl\u00E9 n\u00E1lezy vzbuzuj\u00ED podez\u0159en\u00ED z malignity a jsou nez\u0159\u00EDdka p\u0159edm\u011Btem konzulta\u010Dn\u00EDch biopsi\u00ED. Intravaskul\u00E1rn\u00ED invaze n\u00E1dorov\u00FDch struktur je u v\u011Bt\u0161iny n\u00E1dor\u016F zn\u00E1mkou malignity, ale vz\u00E1cn\u011B v okraji zcela benign\u00EDho pleomorfn\u00EDho adenomu mohou dilatovan\u00E9 krevn\u00ED c\u00E9vy obsahovat %22metastatick\u00E1%22 n\u00E1dorov\u00E1 depozita. P\u0159i absenci jin\u00FDch suspektn\u00EDch morfologick\u00FDch zn\u00E1mek (nekr\u00F3zy, atypick\u00E9 mit\u00F3zy) by m\u011Bl b\u00FDt tento n\u00E1lez ignorov\u00E1n a v \u017E\u00E1dn\u00E9m p\u0159\u00EDpad\u011B by nem\u011Bl b\u00FDt hodnocen jako zvrat v karcinom. Pleomorfn\u00ED adenomy zvl\u00E1\u0161t\u011B mal\u00FDch slinn\u00FDch \u017El\u00E1z mohou obsahovat rozs\u00E1hl\u00E1 lo\u017Eiska skvam\u00F3zn\u00ED a mucin\u00F3zn\u00ED metaplazie napodobuj\u00EDc\u00ED mukoepidermoidn\u00ED karcinom. Absence invazivn\u00EDho r\u016Fstu a translokac\u00ED t(11;19) a t(11;15), a naopak p\u0159\u00EDtomnost chondromyxoidn\u00EDho stromatu potvrd\u00ED spr\u00E1vnou diagn\u00F3zu pleomorfn\u00EDho adenomu. Diagnostick\u00E9 \u00FAskal\u00ED d\u00E1le p\u0159edstavuj\u00ED lo\u017Eiska kribriformn\u00EDch struktur bud\u00EDc\u00ED podez\u0159en\u00ED z adenoidn\u011B cystick\u00E9ho karcinomu a onkocyt\u00E1rn\u00ED diferenciace s atypiemi, kter\u00E9 napodobuj\u00ED zvrat v karcinom. Nej\u010Dast\u011Bji konzultovan\u00E9 pleomorfn\u00ED adenomy jsou celul\u00E1rn\u00ED n\u00E1dory s lo\u017Eisky atypick\u00FDch bun\u011Bk, kter\u00E9 mohou odpov\u00EDdat inici\u00E1ln\u00EDmu zvratu v karcinom in situ, ale pouze atypie k diagn\u00F3ze malignity nesta\u010D\u00ED. Pro malignitu sv\u011Bd\u010D\u00ED vysok\u00FD MIB1 index, exprese HER-2/neu a v\u00FDrazn\u00E9 atypie v lumin\u00E1ln\u00ED dukt\u00E1ln\u00ED vrstv\u011B." . "Pleomorfn\u00ED adenom slinn\u00FDch \u017El\u00E1z: diagnostick\u00E1 \u00FAskal\u00ED a histologick\u00E9 n\u00E1lezy bud\u00EDc\u00ED podez\u0159en\u00ED z malignity" . "Hosti\u010Dka, Lubor" . "Sk\u00E1lov\u00E1, Alena" . . "RIV/00216208:11140/12:10124606" . . "carcinoma ex pleomorphic adenoma; atypical; intravascular tumor deposits; metaplasia; pitfall; pleomorphic adenoma; salivary gland"@en . "Pleomorphic adenoma of salivary glands: diagnostic pitfalls and mimickers of malignancy"@en . . . "Pleomorfn\u00ED adenom slinn\u00FDch \u017El\u00E1z: diagnostick\u00E1 \u00FAskal\u00ED a histologick\u00E9 n\u00E1lezy bud\u00EDc\u00ED podez\u0159en\u00ED z malignity"@cs . . . . "Pleomorphic adenoma of salivary glands: diagnostic pitfalls and mimickers of malignancy"@en . "[0ECB8BC24E4F]" . .