"4" . "Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues"@en . "10" . "Rook, Martin B." . "We designed and synthesized 40 analogues of dofetilide and established structure-activity relationships for their interaction with hERG potassium channel. The data were derived with the aim to specify structural features that give rise to hERG toxicity." . "11"^^ . "11140" . . . "10.1002/cmdc.200900203" . "Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues"@en . . . "RIV/00216208:11140/09:10103260" . . . "314387" . "de Vries, Henk" . . . "RIV/00216208:11140/09:10103260!RIV12-MSM-11140___" . "Vos, Marc A." . "Klaasse, Elisabeth" . . . "1860-7179" . "V" . "Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues" . "We designed and synthesized 40 analogues of dofetilide and established structure-activity relationships for their interaction with hERG potassium channel. The data were derived with the aim to specify structural features that give rise to hERG toxicity."@en . "Exploring chemical substructures essential for hERG K(+) Channel blockade by synthesis and biological evaluation of dofetilide analogues" . "9"^^ . . "Brussee, Johannes" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Nalos, Luk\u00E1\u0161" . "ChemMedChem" . . "[60D7C5DA1407]" . . . "van der Heyden, Marcel A.G." . . "Shagufta, Dong Guo" . "IJzerman, Adriaan, P." . "structure-activity relationships; radioligand binding assays; ion channels; hERG; dofetilide; cardiotoxicity"@en . "1"^^ . . "000270767900017" . .