"55428" . "V\u00FDvoj vakc\u00EDn proti viru dengue" . "Dengue fever represents one of the most widely spread arthropod-borne diseases worldwide. According to recent estimates there are approximately 390 million cases annually. In addition dengue fever is a major cause of mortality in paediatric population living in endemic areas, thus the development of vaccine is highly encouraged. Despite the fact that there is no licensed vaccine available, there are several vaccine candidates in development: live attenuated tetravalent and monovalent, tetravalent chimeric, attenuated, recombinant subunit and DNA vaccines. A tetravalent chimeric vaccine (ChimeriVax-Dengue) has entered into phase III clinical trials. The vaccine candidates are intended for use primarily in children living in endemic areas, thus there will be probably no vaccine available for travellers in the near future."@en . "Hore\u010Dka dengue p\u0159edstavuje celosv\u011Btov\u011B nejroz\u0161\u00ED\u0159en\u011Bj\u0161\u00ED arbovir\u00F3zu a podle nejnov\u011Bj\u0161\u00EDch odhad\u016F se ro\u010Dn\u011B virem nakaz\u00ED 390 milion\u016F osob. Hore\u010Dka dengue je rovn\u011B\u017E \u010Dastou p\u0159\u00ED\u010Dinou \u00FAmrtnosti d\u011Bt\u00ED v endemick\u00FDch oblastech, a proto je kladen d\u016Fraz na v\u00FDvoj \u00FA\u010Dinn\u00E9 o\u010Dkovac\u00ED l\u00E1tky. Dosud nebyla \u017E\u00E1dn\u00E1 vakc\u00EDna uvedena na trh pro b\u011B\u017En\u00E9 u\u017Eit\u00ED, ale bylo vyvinuto n\u011Bkolik slibn\u00FDch kandid\u00E1tn\u00EDch vakc\u00EDn. V\u00FDzkum je zam\u011B\u0159en na \u017Eiv\u00E9 atenuovan\u00E9 tetravalentn\u00ED a monovalentn\u00ED vakc\u00EDny, tetravalentn\u00ED chim\u00E9rick\u00E9, inaktivovan\u00E9, rekombinantn\u00ED podjednotkov\u00E9 a DNA vakc\u00EDny. V sou\u010Dasn\u00E9 dob\u011B nejd\u00E1le pokro\u010Dil v\u00FDvoj tetravalentn\u00ED chim\u00E9rick\u00E9 vakc\u00EDny (ChimeriVax-Dengue), u kter\u00E9 prob\u00EDhaj\u00ED studie III. f\u00E1ze klinick\u00E9ho testov\u00E1n\u00ED. Jeliko\u017E vakc\u00EDny budou ur\u010Deny zejm\u00E9na pro d\u011Bti \u017Eij\u00EDc\u00ED v endemick\u00FDch oblastech, nelze v bl\u00EDzk\u00E9 budoucnosti o\u010Dek\u00E1vat registraci vakc\u00EDny pro cestovatele."@cs . "CZ - \u010Cesk\u00E1 republika" . . . "V\u00FDvoj vakc\u00EDn proti viru dengue"@cs . . "Stejskal, Franti\u0161ek" . "chimeric vaccine; live attenuated vaccine; vaccination; fever; dengue"@en . . . "V\u00FDvoj vakc\u00EDn proti viru dengue" . "1802-3150" . "Hore\u010Dka dengue p\u0159edstavuje celosv\u011Btov\u011B nejroz\u0161\u00ED\u0159en\u011Bj\u0161\u00ED arbovir\u00F3zu a podle nejnov\u011Bj\u0161\u00EDch odhad\u016F se ro\u010Dn\u011B virem nakaz\u00ED 390 milion\u016F osob. Hore\u010Dka dengue je rovn\u011B\u017E \u010Dastou p\u0159\u00ED\u010Dinou \u00FAmrtnosti d\u011Bt\u00ED v endemick\u00FDch oblastech, a proto je kladen d\u016Fraz na v\u00FDvoj \u00FA\u010Dinn\u00E9 o\u010Dkovac\u00ED l\u00E1tky. Dosud nebyla \u017E\u00E1dn\u00E1 vakc\u00EDna uvedena na trh pro b\u011B\u017En\u00E9 u\u017Eit\u00ED, ale bylo vyvinuto n\u011Bkolik slibn\u00FDch kandid\u00E1tn\u00EDch vakc\u00EDn. V\u00FDzkum je zam\u011B\u0159en na \u017Eiv\u00E9 atenuovan\u00E9 tetravalentn\u00ED a monovalentn\u00ED vakc\u00EDny, tetravalentn\u00ED chim\u00E9rick\u00E9, inaktivovan\u00E9, rekombinantn\u00ED podjednotkov\u00E9 a DNA vakc\u00EDny. V sou\u010Dasn\u00E9 dob\u011B nejd\u00E1le pokro\u010Dil v\u00FDvoj tetravalentn\u00ED chim\u00E9rick\u00E9 vakc\u00EDny (ChimeriVax-Dengue), u kter\u00E9 prob\u00EDhaj\u00ED studie III. f\u00E1ze klinick\u00E9ho testov\u00E1n\u00ED. Jeliko\u017E vakc\u00EDny budou ur\u010Deny zejm\u00E9na pro d\u011Bti \u017Eij\u00EDc\u00ED v endemick\u00FDch oblastech, nelze v bl\u00EDzk\u00E9 budoucnosti o\u010Dek\u00E1vat registraci vakc\u00EDny pro cestovatele." . "4"^^ . . . "Development of dengue vaccines"@en . . "V\u00FDvoj vakc\u00EDn proti viru dengue"@cs . . "RIV/00216208:11130/14:10293706!RIV15-MSM-11130___" . "Troj\u00E1nek, Milan" . "Development of dengue vaccines"@en . "3"^^ . . "8" . "V" . "Mare\u0161ov\u00E1, Vilma" . "Vakcinologie" . . "2" . . . "3"^^ . . "11130" . . . "RIV/00216208:11130/14:10293706" . . "[6CEFA77F479F]" . .