"Pulmonary arterial hypertension in cystic fibrosis: a study in adult lung transplant candidates"@en . "[936C1BB3A15E]" . . "lung transplantation; pulmonary arterial hypertension; cystic fibrosis"@en . "4"^^ . "Grandcourtov\u00E1, Al\u017Eb\u011Bta" . "4"^^ . "Studia Pneumologica et Phthiseologica" . "36872" . "Plicn\u00ED arteri\u00E1ln\u00ED hypertenze u cystick\u00E9 fibr\u00F3zy: studie u dosp\u011Bl\u00FDch kandid\u00E1t\u016F transplantace plic" . "I" . "Plicn\u00ED arteri\u00E1ln\u00ED hypertenze u cystick\u00E9 fibr\u00F3zy: studie u dosp\u011Bl\u00FDch kandid\u00E1t\u016F transplantace plic"@cs . "6" . . "74" . . "Kuzma, Monika" . "1"^^ . . . . . "Valentov\u00E1 Bart\u00E1kov\u00E1, Lucie" . "11130" . . "Plicn\u00ED arteri\u00E1ln\u00ED hypertenze u cystick\u00E9 fibr\u00F3zy: studie u dosp\u011Bl\u00FDch kandid\u00E1t\u016F transplantace plic" . . . "Fila, Libor" . "Plicn\u00ED arteri\u00E1ln\u00ED hypertenze u cystick\u00E9 fibr\u00F3zy: studie u dosp\u011Bl\u00FDch kandid\u00E1t\u016F transplantace plic"@cs . "\u00DAvod: Plicn\u00ED arteri\u00E1ln\u00ED hypertenze (PAH) je z\u00E1va\u017Enou komorbiditou u nemocn\u00FDch s pokro\u010Dil\u00FDm plicn\u00EDm onemocn\u011Bn\u00EDm v\u010Detn\u011B cystick\u00E9 fibr\u00F3zy (CF). PAH ovliv\u0148uje morbiditu a mortalitu t\u011Bchto nemocn\u00FDch a zhor\u0161uje jejich kvalitu \u017Eivota i toleranci fyzick\u00E9 n\u00E1mahy. V t\u00E9to studii jsme hodnotili v\u00FDskyt a faktory asociovan\u00E9 s PAH u dosp\u011Bl\u00FDch kandid\u00E1t\u016F transplantace plic (LuTx) s CF. Metodika: Soubor byl tvo\u0159en dosp\u011Bl\u00FDmi s CF za\u0159azen\u00FDmi na \u010Dekac\u00ED listinu (WL) LuTx v Transplanta\u010Dn\u00EDm centru FN Motol v obdob\u00ED 2009-2013. Hodnocen byl v\u011Bk v dob\u011B za\u0159azen\u00ED na WL, pohlav\u00ED, plicn\u00ED funkce (usilovn\u011B vydechnut\u00FD objem za prvn\u00ED sekundu /FEV1/), respira\u010Dn\u00ED parametry (paO2 a paCO2) a tolerance fyzick\u00E9 n\u00E1mahy (u\u0161l\u00E1 vzd\u00E1lenost p\u0159i testu \u0161estiminutovou ch\u016Fz\u00ED /6-MWD/). Tlaky v plicnici byly vy\u0161et\u0159eny pomoc\u00ED pravostrann\u00E9 srde\u010Dn\u00ED katetrizace, hodnocen byl st\u0159edn\u00ED tlak (PAMP). V\u00FDsledky: Do studie bylo za\u0159azeno 19 pacient\u016F (10 mu\u017E\u016F a 9 \u017Een) s pr\u016Fm\u011Brn\u00FDm (+- SD) v\u011Bkem 28,9 +- 8,4 roku. Hodnoty vy\u0161et\u0159en\u00FDch parametr\u016F \u010Dinily: FEV1 23 +- 5 % n\u00E1l. hodn., paO2 7,30 +- 0,86 kPa, paCO2 5,04 +- 0,76 kPa, 6-MWD 297 +- 86 m a PAMP 26 +- 8 mm Hg. Plicn\u00ED hypertenze (PAMP GREATER-THAN OR EQUAL TO 25 mm Hg) byla zji\u0161t\u011Bna u 6 (31,6 %) pacient\u016F. S hodnotou PAMP korelovala hodnota FEV1 (r = -0,495; p = 0,031) a paCO2 (r = 0,463; p = 0,041). V regresn\u00ED anal\u00FDze p\u0159i adjustaci na pohlav\u00ED a v\u011Bk m\u011Bla hodnota FEV1 tendenci (p = 0,057) predikovat hodnotu PAMP. Cut-off hodnota FEV1 < 20 % n\u00E1l. hodn. predikovala hodnotu PAMP GREATER-THAN OR EQUAL TO 25 mm Hg se senzitivitou, specificitou a p\u0159esnost\u00ED 66,7 %, 100,0 % a 89,5 %. Plocha pod ROC k\u0159ivkou pro tuto cut-off hodnotu \u010Dinila 0,70 s dostate\u010Dnou p\u0159esnost\u00ED predikce (p = 0,11). Z\u00E1v\u011Br: PAH je b\u011B\u017Enou komorbiditou pokro\u010Dil\u00E9ho plicn\u00EDho onemocn\u011Bn\u00ED u CF a lze ji o\u010Dek\u00E1vat p\u0159edev\u0161\u00EDm u nemocn\u00FDch s velmi t\u011B\u017Ekou obstrukc\u00ED d\u00FDchac\u00EDch cest." . . . "Pulmonary arterial hypertension in cystic fibrosis: a study in adult lung transplant candidates"@en . "CZ - \u010Cesk\u00E1 republika" . "RIV/00216208:11130/14:10293337" . "Pulmonary arterial hypertension in cystic fibrosis: a study in adult lung transplant candidates Introduction: Pulmonary arterial hypertension (PAH) is a significant comorbidity in patients with advanced lung diseases including cystic fibrosis (CF). PAH affects the morbidity and mortality of these patients and impairs their quality of life and exercise tolerance. The study evaluated the prevalence of and factors associated with PAH in adult lung transplant candidates with CF. Methods: The study group consisted of adults with CF listed on the lung transplant waiting list in the Transplant Center of the University Hospital in Motol (Prague, Czech Republic) during the 2009-2013 period. We evaluated the age at waiting list placement, sex, lung function (forced expiratory volume in the first second [FEV1]), respiratory parameters (PaO2 and PaCO2) and exercise tolerance (six-minute walking distance [6-MWD]). Pulmonary artery pressures were examined using right heart catheterization and pulmonary artery mean pressure (PAMP) was evaluated. Results: Nineteen patients (10 men and 9 women) with a mean (+- SD) age of 28.9 +- 8.4 years were included into study. The values of the examined parameters were as follows: FEV1 23 +- 5 % pred., PaO2 7.30 +- 0.86 kPa, PaCO2 5.04 +- 0.76 kPa, 6-MWD 297 +- 86 m and PAMP 26 +- 8 mmHg. Pulmonary hypertension (PAMP GREATER-THAN OR EQUAL TO 25 mmHg) was observed in 6 (31.6 %) patients. The values of FEV1 (r = -0.495; p = 0.031) and PaCO2 (r = 0.463; p = 0.041) correlated with the PAMP value. In regression analysis adjusted for sex and age, the FEV1 value showed a tendency (p = 0.057) to predict the PAMP value. The cut-off value of FEV1 < 20 % pred. predicted the PAMP value GREATER-THAN OR EQUAL TO 25 mmHg with sensitivity, specificity and accuracy of 66.7 %, 100.0 % and 89.5 %, respectively. The area under the ROC curve for this cut-off value was 0.70 with fair accuracy of prediction (p = 0.11)."@en . "\u00DAvod: Plicn\u00ED arteri\u00E1ln\u00ED hypertenze (PAH) je z\u00E1va\u017Enou komorbiditou u nemocn\u00FDch s pokro\u010Dil\u00FDm plicn\u00EDm onemocn\u011Bn\u00EDm v\u010Detn\u011B cystick\u00E9 fibr\u00F3zy (CF). PAH ovliv\u0148uje morbiditu a mortalitu t\u011Bchto nemocn\u00FDch a zhor\u0161uje jejich kvalitu \u017Eivota i toleranci fyzick\u00E9 n\u00E1mahy. V t\u00E9to studii jsme hodnotili v\u00FDskyt a faktory asociovan\u00E9 s PAH u dosp\u011Bl\u00FDch kandid\u00E1t\u016F transplantace plic (LuTx) s CF. Metodika: Soubor byl tvo\u0159en dosp\u011Bl\u00FDmi s CF za\u0159azen\u00FDmi na \u010Dekac\u00ED listinu (WL) LuTx v Transplanta\u010Dn\u00EDm centru FN Motol v obdob\u00ED 2009-2013. Hodnocen byl v\u011Bk v dob\u011B za\u0159azen\u00ED na WL, pohlav\u00ED, plicn\u00ED funkce (usilovn\u011B vydechnut\u00FD objem za prvn\u00ED sekundu /FEV1/), respira\u010Dn\u00ED parametry (paO2 a paCO2) a tolerance fyzick\u00E9 n\u00E1mahy (u\u0161l\u00E1 vzd\u00E1lenost p\u0159i testu \u0161estiminutovou ch\u016Fz\u00ED /6-MWD/). Tlaky v plicnici byly vy\u0161et\u0159eny pomoc\u00ED pravostrann\u00E9 srde\u010Dn\u00ED katetrizace, hodnocen byl st\u0159edn\u00ED tlak (PAMP). V\u00FDsledky: Do studie bylo za\u0159azeno 19 pacient\u016F (10 mu\u017E\u016F a 9 \u017Een) s pr\u016Fm\u011Brn\u00FDm (+- SD) v\u011Bkem 28,9 +- 8,4 roku. Hodnoty vy\u0161et\u0159en\u00FDch parametr\u016F \u010Dinily: FEV1 23 +- 5 % n\u00E1l. hodn., paO2 7,30 +- 0,86 kPa, paCO2 5,04 +- 0,76 kPa, 6-MWD 297 +- 86 m a PAMP 26 +- 8 mm Hg. Plicn\u00ED hypertenze (PAMP GREATER-THAN OR EQUAL TO 25 mm Hg) byla zji\u0161t\u011Bna u 6 (31,6 %) pacient\u016F. S hodnotou PAMP korelovala hodnota FEV1 (r = -0,495; p = 0,031) a paCO2 (r = 0,463; p = 0,041). V regresn\u00ED anal\u00FDze p\u0159i adjustaci na pohlav\u00ED a v\u011Bk m\u011Bla hodnota FEV1 tendenci (p = 0,057) predikovat hodnotu PAMP. Cut-off hodnota FEV1 < 20 % n\u00E1l. hodn. predikovala hodnotu PAMP GREATER-THAN OR EQUAL TO 25 mm Hg se senzitivitou, specificitou a p\u0159esnost\u00ED 66,7 %, 100,0 % a 89,5 %. Plocha pod ROC k\u0159ivkou pro tuto cut-off hodnotu \u010Dinila 0,70 s dostate\u010Dnou p\u0159esnost\u00ED predikce (p = 0,11). Z\u00E1v\u011Br: PAH je b\u011B\u017Enou komorbiditou pokro\u010Dil\u00E9ho plicn\u00EDho onemocn\u011Bn\u00ED u CF a lze ji o\u010Dek\u00E1vat p\u0159edev\u0161\u00EDm u nemocn\u00FDch s velmi t\u011B\u017Ekou obstrukc\u00ED d\u00FDchac\u00EDch cest."@cs . . . "RIV/00216208:11130/14:10293337!RIV15-MSM-11130___" . "1213-810X" .