. . "New molecular biology methods have specified the evidence of chromosomal changes in the tumor tissue. These alterations can be proven to exist in the majority of malignant tumors. The fast progress of whole genome molecular biological methods has helped to improve the knowledge of tumor genetics. The evidence of genetic changes is a component of currently used diagnostic and prognostic schemes in particular cancer diseases. Karyotyping was the first method used in the clinical practice but its importance has decreased with the arrival of new molecular biological methods. The most common methods used for the detection of chromosomal deletions or amplifications are CGH, array-CGH and SNP array. The first two methods are based on the principle of comparison between tumor DNA and control DNA. The principle of SNP array uses the presence of single nucleotide polymorphisms that are located in the whole genome in each individual. SNP array can prove not only deletions or amplifications of the chromosomes but unlike CGH techniques it can also detect a loss of heterozygosity or uniparental disomy. The screening of chromosomal changes has nowadays become routine. These techniques are used for diagnosis, prognosis and treatment of cancer disease in certain cases."@en . "Pr\u016Fkaz chromozom\u00E1ln\u00EDch zm\u011Bn u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED pomoc\u00ED CGH, array-CGH a SNP array"@cs . "RIV/00216208:11130/14:10288815" . . "40652" . "[6CDC02AA71FB]" . "http://www.prolekare.cz/linkout/48155" . "Nov\u00E9 molekul\u00E1rn\u011B biologick\u00E9 metody umo\u017Enily zp\u0159esn\u011Bn\u00ED pr\u016Fkazu chromozom\u00E1ln\u00EDch zm\u011Bn v n\u00E1dorov\u00E9 tk\u00E1ni. Tyto zm\u011Bny lze prok\u00E1zat u v\u011Bt\u0161iny malign\u00EDch n\u00E1dor\u016F. Rychl\u00FD rozvoj celogenomov\u00FDch molekul\u00E1rn\u011B biologick\u00FDch metod napomohl zlep\u0161en\u00ED pozn\u00E1n\u00ED genetick\u00E9ho pozad\u00ED n\u00E1dor\u016F. V sou\u010Dasn\u00E9 dob\u011B je jejich pr\u016Fkaz sou\u010D\u00E1st\u00ED diagnostick\u00FDch nebo prognostick\u00FDch sch\u00E9mat pou\u017E\u00EDvan\u00FDch u jednotliv\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Jako prvn\u00ED bylo v klinick\u00E9 praxi vyu\u017E\u00ED- v\u00E1no klasick\u00E9 cytogenetick\u00E9 vy\u0161et\u0159en\u00ED karyotypu, kter\u00E9 je vyu\u017E\u00EDv\u00E1no dodnes, i kdy\u017E s n\u00E1stupem nov\u00FDch molekul\u00E1rn\u011B biologick\u00FDch technik se jeho v\u00FDznam zmen\u0161il. Metodami dnes nej\u010Dast\u011Bji pou\u017E\u00EDvan\u00FDmi ke stanoven\u00ED chromozom\u00E1ln\u00EDch delec\u00ED nebo zmno\u017Een\u00ED p\u0159i celogenomov\u00E9m vy\u0161et\u0159en\u00ED jsou komparativn\u00ED genomov\u00E1 hybridizace (CGH), array-CGH a SNP array. Prvn\u00ED dv\u011B jsou zalo\u017Eeny na principu porovn\u00E1n\u00ED n\u00E1dorov\u00E9 DNA a norm\u00E1ln\u00ED, kontroln\u00ED DNA. Princip SNP array vyu\u017E\u00EDv\u00E1 p\u0159\u00EDtomnosti jednonukleov\u00FDch polymorfism\u016F rozlo\u017Een\u00FDch po cel\u00E9m genomu u ka\u017Ed\u00E9ho jedince. SNP array prokazuje nejen delece nebo zmno\u017Een\u00ED chromoz\u00F3m\u016F, tak jak je tomu u CGH technik, ale je schopna prok\u00E1zat i ztr\u00E1tu heterozygozyty nebo unipatern\u00E1ln\u00ED dizomii. Vy\u0161et\u0159en\u00ED chromozom\u00E1ln\u00EDch zm\u011Bn se dnes st\u00E1v\u00E1 rutinn\u00EDm a v n\u011Bkter\u00FDch p\u0159\u00EDpadech tak\u00E9 nezbytn\u00FDm vy\u0161et\u0159en\u00EDm pro stanoven\u00E9 diagn\u00F3zy a progn\u00F3zy n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED a spr\u00E1vn\u00E9ho v\u00FDb\u011Bru onkologick\u00E9 terapie." . . "genetic aberration; SNP array; array-CGH; CGH; cytogenetic"@en . "Detection of chromosome changes by CGH, array-CGH and SNP array techniques in tumours"@en . . . . "Pr\u016Fkaz chromozom\u00E1ln\u00EDch zm\u011Bn u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED pomoc\u00ED CGH, array-CGH a SNP array"@cs . "3"^^ . . "RIV/00216208:11130/14:10288815!RIV15-MSM-11130___" . . "50" . "3"^^ . . "Detection of chromosome changes by CGH, array-CGH and SNP array techniques in tumours"@en . . "V\u00EDcha, Ale\u0161" . "Nov\u00E9 molekul\u00E1rn\u011B biologick\u00E9 metody umo\u017Enily zp\u0159esn\u011Bn\u00ED pr\u016Fkazu chromozom\u00E1ln\u00EDch zm\u011Bn v n\u00E1dorov\u00E9 tk\u00E1ni. Tyto zm\u011Bny lze prok\u00E1zat u v\u011Bt\u0161iny malign\u00EDch n\u00E1dor\u016F. Rychl\u00FD rozvoj celogenomov\u00FDch molekul\u00E1rn\u011B biologick\u00FDch metod napomohl zlep\u0161en\u00ED pozn\u00E1n\u00ED genetick\u00E9ho pozad\u00ED n\u00E1dor\u016F. V sou\u010Dasn\u00E9 dob\u011B je jejich pr\u016Fkaz sou\u010D\u00E1st\u00ED diagnostick\u00FDch nebo prognostick\u00FDch sch\u00E9mat pou\u017E\u00EDvan\u00FDch u jednotliv\u00FDch n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED. Jako prvn\u00ED bylo v klinick\u00E9 praxi vyu\u017E\u00ED- v\u00E1no klasick\u00E9 cytogenetick\u00E9 vy\u0161et\u0159en\u00ED karyotypu, kter\u00E9 je vyu\u017E\u00EDv\u00E1no dodnes, i kdy\u017E s n\u00E1stupem nov\u00FDch molekul\u00E1rn\u011B biologick\u00FDch technik se jeho v\u00FDznam zmen\u0161il. Metodami dnes nej\u010Dast\u011Bji pou\u017E\u00EDvan\u00FDmi ke stanoven\u00ED chromozom\u00E1ln\u00EDch delec\u00ED nebo zmno\u017Een\u00ED p\u0159i celogenomov\u00E9m vy\u0161et\u0159en\u00ED jsou komparativn\u00ED genomov\u00E1 hybridizace (CGH), array-CGH a SNP array. Prvn\u00ED dv\u011B jsou zalo\u017Eeny na principu porovn\u00E1n\u00ED n\u00E1dorov\u00E9 DNA a norm\u00E1ln\u00ED, kontroln\u00ED DNA. Princip SNP array vyu\u017E\u00EDv\u00E1 p\u0159\u00EDtomnosti jednonukleov\u00FDch polymorfism\u016F rozlo\u017Een\u00FDch po cel\u00E9m genomu u ka\u017Ed\u00E9ho jedince. SNP array prokazuje nejen delece nebo zmno\u017Een\u00ED chromoz\u00F3m\u016F, tak jak je tomu u CGH technik, ale je schopna prok\u00E1zat i ztr\u00E1tu heterozygozyty nebo unipatern\u00E1ln\u00ED dizomii. Vy\u0161et\u0159en\u00ED chromozom\u00E1ln\u00EDch zm\u011Bn se dnes st\u00E1v\u00E1 rutinn\u00EDm a v n\u011Bkter\u00FDch p\u0159\u00EDpadech tak\u00E9 nezbytn\u00FDm vy\u0161et\u0159en\u00EDm pro stanoven\u00E9 diagn\u00F3zy a progn\u00F3zy n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED a spr\u00E1vn\u00E9ho v\u00FDb\u011Bru onkologick\u00E9 terapie."@cs . "\u010Cesko-slovensk\u00E1 patologie a Soudn\u00ED l\u00E9ka\u0159stv\u00ED" . . . "1" . "1210-7875" . "Musil, Zden\u011Bk" . . . "5"^^ . "Pr\u016Fkaz chromozom\u00E1ln\u00EDch zm\u011Bn u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED pomoc\u00ED CGH, array-CGH a SNP array" . "I" . "Voseck\u00E1, Tatiana" . "CZ - \u010Cesk\u00E1 republika" . "Pr\u016Fkaz chromozom\u00E1ln\u00EDch zm\u011Bn u n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED pomoc\u00ED CGH, array-CGH a SNP array" . . . . "11130" .