"Osteosarkomy jsou vz\u00E1cn\u00E1 onemocn\u011B n\u00ED, p\u0159esto se jedn\u00E1 o nej\u010Dast\u011Bj\u0161\u00ED malign\u00ED n\u00E1dory vznikaj\u00EDc\u00ED v kostech a postihuj\u00ED ze jm\u00E9na jedince mlad\u0161\u00ED 20 let. Mifamurtid je po dlouh\u00E9 dob\u011B nov\u011B registrovan\u00FD l\u00E9k indi kovan\u00FD k l\u00E9\u010Db\u011B resekovateln\u00E9ho nemetasta tick\u00E9ho osteosarkomu u d\u011Bt\u00ED, mladistv\u00FDch a mlad\u00FDch dosp\u011Bl\u00FDch po makroskopicky radik\u00E1ln\u00EDm chirurgick\u00E9m v\u00FDkonu. Pou\u017E\u00EDv\u00E1 se v kombinaci s poopera\u010Dn\u00ED polychemoterapi\u00ED v d\u00E1vce 2 mg/m 2 2x t\u00FDdn\u011B s odstupem nejm\u00E9n\u011B 3 dn\u016F po 12 t\u00FDdn\u016F a n\u00E1sledn\u011B dal\u0161\u00EDch 24 t\u00FDdn\u016F 1x t\u00FDdn\u011B do maxim\u00E1ln\u00EDho po\u010Dtu 48 infuz\u00ED b\u011Bhem 36 t\u00FDdn\u016F."@cs . "9" . "RIV/00216208:11130/13:10294181" . . . "Kub\u00E1\u010Dkov\u00E1, Kate\u0159ina" . "88278" . "11130" . . "Mifamurtid - nov\u00FD terapeutick\u00FD p\u0159\u00EDstup pro adjuvantn\u00ED l\u00E9\u010Dbu osteosarkom\u016F"@cs . "I" . "Mifamurtid - nov\u00FD terapeutick\u00FD p\u0159\u00EDstup pro adjuvantn\u00ED l\u00E9\u010Dbu osteosarkom\u016F" . "osteosarcomas; Mifamurtide"@en . . . . "Mifamurtide - a new approach to adjuvant therapy of osteosarcomas"@en . "Farmakoterapie" . "Mifamurtide - a new approach to adjuvant therapy of osteosarcomas"@en . . . "RIV/00216208:11130/13:10294181!RIV15-MSM-11130___" . "4"^^ . . "Mifamurtid - nov\u00FD terapeutick\u00FD p\u0159\u00EDstup pro adjuvantn\u00ED l\u00E9\u010Dbu osteosarkom\u016F"@cs . "Mifamurtid - nov\u00FD terapeutick\u00FD p\u0159\u00EDstup pro adjuvantn\u00ED l\u00E9\u010Dbu osteosarkom\u016F" . . "CZ - \u010Cesk\u00E1 republika" . "1"^^ . "Osteosarcomas are rare diseases but are still the most common malignant tumours developing in bones and affect especially individuals younger than 20 years. After a long time, mifamurtide has recently been approved as a new drug indicated for the treatment of resected nonmetastatic osteo- sarcoma in children, adolescents and young adults after macroscopically radical surgical procedure. It is used in combination with post surgery polychemotherapy in the dose of 2 mg/m 2 twice a week separated by at least 3 days for 12 weeks, and for another 24 weeks once weekly up to the maximum number of 48 infusions within 36 weeks."@en . "Osteosarkomy jsou vz\u00E1cn\u00E1 onemocn\u011B n\u00ED, p\u0159esto se jedn\u00E1 o nej\u010Dast\u011Bj\u0161\u00ED malign\u00ED n\u00E1dory vznikaj\u00EDc\u00ED v kostech a postihuj\u00ED ze jm\u00E9na jedince mlad\u0161\u00ED 20 let. Mifamurtid je po dlouh\u00E9 dob\u011B nov\u011B registrovan\u00FD l\u00E9k indi kovan\u00FD k l\u00E9\u010Db\u011B resekovateln\u00E9ho nemetasta tick\u00E9ho osteosarkomu u d\u011Bt\u00ED, mladistv\u00FDch a mlad\u00FDch dosp\u011Bl\u00FDch po makroskopicky radik\u00E1ln\u00EDm chirurgick\u00E9m v\u00FDkonu. Pou\u017E\u00EDv\u00E1 se v kombinaci s poopera\u010Dn\u00ED polychemoterapi\u00ED v d\u00E1vce 2 mg/m 2 2x t\u00FDdn\u011B s odstupem nejm\u00E9n\u011B 3 dn\u016F po 12 t\u00FDdn\u016F a n\u00E1sledn\u011B dal\u0161\u00EDch 24 t\u00FDdn\u016F 1x t\u00FDdn\u011B do maxim\u00E1ln\u00EDho po\u010Dtu 48 infuz\u00ED b\u011Bhem 36 t\u00FDdn\u016F." . . . "1"^^ . . "5" . "1801-1209" . "[BBB8AE32D313]" .