. "2013" . "RIV/00216208:11130/13:10210370!RIV14-GA0-11130___" . "P(GA13-01710S), S" . "http://www.tigis.cz/images/stories/Fyziologie/2013/01/Chovanec.pdf" . "Vztah voln\u00FDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F a oxidu dusnat\u00E9ho p\u0159i vzniku plicn\u00ED hypertenze" . . "1"^^ . . . "CZ - \u010Cesk\u00E1 republika" . . . . "\u010Ceskoslovensk\u00E1 fyziologie" . "117020" . "1"^^ . . "[6999927A63F4]" . "Vztah voln\u00FDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F a oxidu dusnat\u00E9ho p\u0159i vzniku plicn\u00ED hypertenze"@cs . . "1210-6313" . "Vztah voln\u00FDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F a oxidu dusnat\u00E9ho p\u0159i vzniku plicn\u00ED hypertenze"@cs . . . . "Plicn\u00ED cirkulace je jak morfologicky tak i funk\u010Dn\u011B odli\u0161n\u00E1 od cirkulace syst\u00E9mov\u00E9. P\u016Fsoben\u00EDm chronick\u00E9 hypoxie vznik\u00E1 plicn\u00ED hypertenze (HPH) charakterizovan\u00E1 vazokonstrikc\u00ED a remodelac\u00ED perifern\u00EDch plicn\u00EDch arteriol. Na tomto procesu se pod\u00EDl\u00ED oxid dusnat\u00FD (NO) a voln\u00E9 kysl\u00EDkov\u00E9 radik\u00E1ly, hlavn\u011B superoxid; po interakci s kysl\u00EDkov\u00FDmi radik\u00E1ly hraje roli p\u0159i remodelaci plicn\u00EDch perifern\u00EDch arteriol. Superoxid po\u0161kozuje st\u011Bny prealveol\u00E1rn\u00EDch plicn\u00EDch c\u00E9v. Vznikl\u00FD peroxynitrit modifikuje kolagen intercelul\u00E1rn\u00ED matrix perifern\u00EDch plicn\u00EDch arteriol pomoc\u00ED specifick\u00FDch metaloprotein\u00E1z, uvoln\u011Bn\u00FDch z \u017E\u00EDrn\u00FDch bun\u011Bk. \u0160t\u011Bpen\u00ED kolagenu se pod\u00EDl\u00ED na mechanismu morfologick\u00E9 p\u0159estavby perifern\u00EDch plicn\u00EDch c\u00E9v, kter\u00E1 spo\u010D\u00EDv\u00E1 v muskularizaci a fibrotizaci jejich st\u011Bny. Zm\u011Bny vznikaj\u00ED u potkana v pr\u016Fb\u011Bhu prvn\u00EDho t\u00FDdne p\u016Fsoben\u00ED chronick\u00E9 hypoxie, co\u017E koreluje se vzestupem st\u0159edn\u00EDho arteri\u00E1ln\u00EDho krevn\u00EDho tlaku v pl\u00EDcnici. P\u0159i d\u00E9le pokra\u010Duj\u00EDc\u00EDm p\u016Fsoben\u00ED chronick\u00E9 hypoxie tyto procesy ji\u017E d\u00E1le neprogreduj\u00ED." . "Role of reactive oxygen species and nitric oxide in development of the hypoxic pulmonary hypertension"@en . "Vztah voln\u00FDch kysl\u00EDkov\u00FDch radik\u00E1l\u016F a oxidu dusnat\u00E9ho p\u0159i vzniku plicn\u00ED hypertenze" . "Role of reactive oxygen species and nitric oxide in development of the hypoxic pulmonary hypertension"@en . "6"^^ . "Plicn\u00ED cirkulace je jak morfologicky tak i funk\u010Dn\u011B odli\u0161n\u00E1 od cirkulace syst\u00E9mov\u00E9. P\u016Fsoben\u00EDm chronick\u00E9 hypoxie vznik\u00E1 plicn\u00ED hypertenze (HPH) charakterizovan\u00E1 vazokonstrikc\u00ED a remodelac\u00ED perifern\u00EDch plicn\u00EDch arteriol. Na tomto procesu se pod\u00EDl\u00ED oxid dusnat\u00FD (NO) a voln\u00E9 kysl\u00EDkov\u00E9 radik\u00E1ly, hlavn\u011B superoxid; po interakci s kysl\u00EDkov\u00FDmi radik\u00E1ly hraje roli p\u0159i remodelaci plicn\u00EDch perifern\u00EDch arteriol. Superoxid po\u0161kozuje st\u011Bny prealveol\u00E1rn\u00EDch plicn\u00EDch c\u00E9v. Vznikl\u00FD peroxynitrit modifikuje kolagen intercelul\u00E1rn\u00ED matrix perifern\u00EDch plicn\u00EDch arteriol pomoc\u00ED specifick\u00FDch metaloprotein\u00E1z, uvoln\u011Bn\u00FDch z \u017E\u00EDrn\u00FDch bun\u011Bk. \u0160t\u011Bpen\u00ED kolagenu se pod\u00EDl\u00ED na mechanismu morfologick\u00E9 p\u0159estavby perifern\u00EDch plicn\u00EDch c\u00E9v, kter\u00E1 spo\u010D\u00EDv\u00E1 v muskularizaci a fibrotizaci jejich st\u011Bny. Zm\u011Bny vznikaj\u00ED u potkana v pr\u016Fb\u011Bhu prvn\u00EDho t\u00FDdne p\u016Fsoben\u00ED chronick\u00E9 hypoxie, co\u017E koreluje se vzestupem st\u0159edn\u00EDho arteri\u00E1ln\u00EDho krevn\u00EDho tlaku v pl\u00EDcnici. P\u0159i d\u00E9le pokra\u010Duj\u00EDc\u00EDm p\u016Fsoben\u00ED chronick\u00E9 hypoxie tyto procesy ji\u017E d\u00E1le neprogreduj\u00ED."@cs . "RIV/00216208:11130/13:10210370" . "Pulmonary circulation is completely different compared to systemic circulation. Chronic hypoxia damages peripheral pulmonary arterioles and causes hypoxic pulmonary hypertension (HPH) which consists of vasoconstriction and remodelling of the arterioles. The release of reactive oxygen species (ROS) - mainly superoxide and nitric oxide (NO) contribute to the pathogenesis of HPH. During exposition to chronic hypoxia, the NO production is markedly elevated and it has two effects: the first, direct vasodilatory effect caused by NO, the second, contribution to remodelling of the peripheral pulmonary vessels by interaction with ROS. The interaction of superoxid and NO releases peroxynitrite which plays a role in the onset of collagen cleavage. A typical low molecular weight of collagen fragments induces remodelling of the peripheral pulmonary arterioles. These changes are typical for the first week of exposure to the chronic hypoxia which also correlates with sudden elevation of the mean pulmonary artery pressure. Continual exposition to the chronic hypoxia after first week does not cause progressive worsening of HPH."@en . . "nitric oxide; superoxide; chronic hypoxia; hypoxic pulmonary hypertension"@en . . . "Chovanec, Milan" . . . . "62" . "11130" .