. "Fixed combination telmisartan/ amlodipine"@en . . "7" . "Widimsky, J." . . "Fixn\u00ED kombinace telmisartan/amlodipin" . "Fixed combination telmisartan/ amlodipine"@en . "RIV/00216208:11130/11:7400!RIV12-MSM-11130___" . . . . . "1"^^ . "telmisartan; amlodipine"@en . "2"^^ . "I" . "Kombinace AT1-blok\u00E1toru telmisartanu a blok\u00E1toru kalciov\u00FDch kan\u00E1l\u016F amlodipinu je novou a perspektivn\u00ED fixn\u00ED kombinac\u00ED v l\u00E9\u010Db\u011B arteri\u00E1ln\u00ED hypertenze. D\u00EDky rozd\u00EDln\u00FDm mechanism\u016Fm p\u016Fsoben\u00ED obou l\u00E1tek m\u00E1 tato kombinace v\u00FDrazn\u00FD aditivn\u00ED antihypertenzn\u00ED \u00FA\u010Dinek, kter\u00FD je nav\u00EDc umoc\u0148ov\u00E1n dlouh\u00FDm biologick\u00FDm polo\u010Dasem amlodipinu i telmisartanu. Pou\u017Eit\u00ED fixn\u00ED kombinace telmisartan/amlodipin v d\u00E1vce 1x denn\u011B vede k v\u00FDrazn\u00E9mu poklesu krevn\u00EDho tlaku u mlad\u0161\u00EDch i star\u0161\u00EDch osob, u pacient\u016F s diabetes mellitus, obezitou \u010Di izolovanou systolickou hypertenz\u00ED. P\u0159\u00EDtomnost telmisartanu sni\u017Euje riziko amlodipinem indukovan\u00E9 tvorby perifern\u00EDch otok\u016F. Je rovn\u011B\u017E d\u016Fle\u017Eit\u00E9, \u017Ee telmisartan i amlodipin maj\u00ED z rozs\u00E1hl\u00FDch randomizovan\u00FDch studi\u00ED dostatek d\u016Fkaz\u016F o p\u0159\u00EDzniv\u00E9m ovlivn\u011Bn\u00ED kardiovaskul\u00E1rn\u00ED morbidity a mortality."@cs . "11130" . "Fixn\u00ED kombinace telmisartan/amlodipin"@cs . "CZ - \u010Cesk\u00E1 republika" . . "[8C62DF4527FC]" . . "Kombinace AT1-blok\u00E1toru telmisartanu a blok\u00E1toru kalciov\u00FDch kan\u00E1l\u016F amlodipinu je novou a perspektivn\u00ED fixn\u00ED kombinac\u00ED v l\u00E9\u010Db\u011B arteri\u00E1ln\u00ED hypertenze. D\u00EDky rozd\u00EDln\u00FDm mechanism\u016Fm p\u016Fsoben\u00ED obou l\u00E1tek m\u00E1 tato kombinace v\u00FDrazn\u00FD aditivn\u00ED antihypertenzn\u00ED \u00FA\u010Dinek, kter\u00FD je nav\u00EDc umoc\u0148ov\u00E1n dlouh\u00FDm biologick\u00FDm polo\u010Dasem amlodipinu i telmisartanu. Pou\u017Eit\u00ED fixn\u00ED kombinace telmisartan/amlodipin v d\u00E1vce 1x denn\u011B vede k v\u00FDrazn\u00E9mu poklesu krevn\u00EDho tlaku u mlad\u0161\u00EDch i star\u0161\u00EDch osob, u pacient\u016F s diabetes mellitus, obezitou \u010Di izolovanou systolickou hypertenz\u00ED. P\u0159\u00EDtomnost telmisartanu sni\u017Euje riziko amlodipinem indukovan\u00E9 tvorby perifern\u00EDch otok\u016F. Je rovn\u011B\u017E d\u016Fle\u017Eit\u00E9, \u017Ee telmisartan i amlodipin maj\u00ED z rozs\u00E1hl\u00FDch randomizovan\u00FDch studi\u00ED dostatek d\u016Fkaz\u016F o p\u0159\u00EDzniv\u00E9m ovlivn\u011Bn\u00ED kardiovaskul\u00E1rn\u00ED morbidity a mortality." . "http://www.medvik.cz/link/bmc11015681" . "6"^^ . "Sl\u00EDva, Ji\u0159\u00ED" . . . . "1" . . "Fixn\u00ED kombinace telmisartan/amlodipin"@cs . . "Farmakoterapie" . "The combination of telmisartan, an AT1-blocker, and amlodipine, a calcium channel blocker, is a novel and promising fixed combination for the therapy of arterial hypertension. As a result of the differing mechanisms of action of both substances this combination exhibits a marked additive antihypertensive action that is further augmented by the long half-lives of both amlodipine and telmisartan. The use of the fixed combination telmisartan/ amlodipine in one daily dose results in marked reduction of blood pressure in both young and older individuals, in patients with diabetes mellitus, obesity, or isolated systolic hypertension. The action of telmisartan reduces the risk of amlodipine-induced formation of peripheral oedema. An important aspect is that both telmisartan and amlodipine have sufficient body of evidence from extensive randomized trials supporting positive effects on cardiovascular morbidity and mortality."@en . "RIV/00216208:11130/11:7400" . "199904" . "1801-1209" . "Fixn\u00ED kombinace telmisartan/amlodipin" .