. "Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease" . . "7"^^ . . "000294913700003" . . . "Th17 lymphocytes; hyper-IgE; chronic granulomatous disease; candida infections; hyper-ige syndrome; t(h)17 cells; dendritic cells; interleukin-17; responses; pathway; card9; il-23; il-17; differentiation"@en . "Clinical and Experimental Immunology" . "Ro\u017Ekov\u00E1, Daniela" . . "Sedl\u00E1\u010Dek, Petr" . . . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "La\u0161\u0165ovi\u010Dka, Jan" . "\u0160ediv\u00E1, Anna" . . "7"^^ . . . "http://www.ncbi.nlm.nih.gov/pubmed/21910722" . . . "8"^^ . . . . "0009-9104" . . "11130" . "1" . . "Hyper-immunoglobulin (Ig) E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD). We analysed the characteristics of the Th17 compartment in HIES and CGD. HIES patients showed very low numbers of Th17 cells. By contrast, the frequency of Th17 cells and production of Th17-derived cytokines was significantly higher among CGD patients when compared to both control samples and HIES. Naive CD4(+) cells in CGD patients had a normal capacity to differentiate into IL-17-producing cells and the numbers of Th17 cells in the CGD patients normalized following successful bone marrow transplantation. Our findings complement recent data on the importance of Th17 cells for elimination of infections with C. albicans and S. aureus."@en . "Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease"@en . "\u0160p\u00ED\u0161ek, Radek" . . "Polou\u010Dkov\u00E1, Andrea" . . "RIV/00216208:11130/11:7091" . "Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease"@en . . "Hyper-immunoglobulin (Ig) E syndrome (HIES) is a primary immunodeficiency associated with mutations in STAT3 resulting in impaired development of T helper type 17 (Th17) lymphocytes. HIES patients with a reduced frequency of Th17 cells present with infections caused by Staphylococcus aureus and/or Candida strains. The same spectrum of pathogens is present in patients with chronic granulomatous disease (CGD). We analysed the characteristics of the Th17 compartment in HIES and CGD. HIES patients showed very low numbers of Th17 cells. By contrast, the frequency of Th17 cells and production of Th17-derived cytokines was significantly higher among CGD patients when compared to both control samples and HIES. Naive CD4(+) cells in CGD patients had a normal capacity to differentiate into IL-17-producing cells and the numbers of Th17 cells in the CGD patients normalized following successful bone marrow transplantation. Our findings complement recent data on the importance of Th17 cells for elimination of infections with C. albicans and S. aureus." . "[06A8A937DC95]" . . . . "198676" . . "Expansion of T helper type 17 lymphocytes in patients with chronic granulomatous disease" . . . "RIV/00216208:11130/11:7091!RIV12-MZ0-11130___" . . . "Horv\u00E1th, Rudolf" . "166" . "P(NS10489), Z(MSM0021620812)" . . . . . .