"Rivadeneira, F." . "Nothnagel, M." . "11130" . "Uitterlinden, AG" . . . . . "Becker, C." . "Hofman, A." . "Sajantila, A." . "Ploski, R." . "Bindoff, LA" . "Genetic matching potentially provides a means to alleviate the effects of incomplete Mendelian randomization in population-based gene-disease association studies. We therefore evaluated the genetic-matched pair study design on the basis of genome-wide SNP data (309 790 markers; Affymetrix GeneChip Human Mapping 500K Array) from 2457 individuals, sampled at 23 different recruitment sites across Europe. Using pair-wise identity-by-state (IBS) as a matching criterion, we tried to derive a subset of markers that would allow identification of the best overall matching (BOM) partner for a given individual, based on the IBS status for the subset alone. However, our results suggest that, by following this approach, the prediction accuracy is only notably improved by the first 20 markers selected, and increases proportionally to the marker number thereafter. Furthermore, in a considerable proportion of cases (76.0%), the BOM of a given individual, based on the complete marker set, came from a different recruit" . "Werge, T." . "1018-4813" . "An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population" . "RIV/00216208:11130/09:5338" . "Tagliabracci, A." . "Lu, TT" . "population structure; matching; association; ancestry; microarray; disease association; genotype data"@en . . "Nurnberg, P." . "Freitag-Wolf, S." . "Genetic matching potentially provides a means to alleviate the effects of incomplete Mendelian randomization in population-based gene-disease association studies. We therefore evaluated the genetic-matched pair study design on the basis of genome-wide SNP data (309 790 markers; Affymetrix GeneChip Human Mapping 500K Array) from 2457 individuals, sampled at 23 different recruitment sites across Europe. Using pair-wise identity-by-state (IBS) as a matching criterion, we tried to derive a subset of markers that would allow identification of the best overall matching (BOM) partner for a given individual, based on the IBS status for the subset alone. However, our results suggest that, by following this approach, the prediction accuracy is only notably improved by the first 20 markers selected, and increases proportionally to the marker number thereafter. Furthermore, in a considerable proportion of cases (76.0%), the BOM of a given individual, based on the complete marker set, came from a different recruit"@en . "Krawczak, M." . "[DBA477D2639E]" . . . "2"^^ . "Parson, W." . "An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population" . "000267141600017" . "Nelson, M. R." . "RIV/00216208:11130/09:5338!RIV10-MZ0-11130___" . . . . . "Mollet, I." . "302720" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population"@en . . . "Gether, U." . "An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population"@en . . "Kayser, M." . "17" . "Macek, Milan" . . . "34"^^ . . "Caliebe, A." . "9"^^ . "7" . "Lao, O." . "P(NR9448), Z(MZ0FNM2005)" . "Comas, D." . . "Holmlund, G." . "Bertranpetit, J." . "Schreiber, S." . . "Junge, O." . . "Bala\u0161\u010Dakov\u00E1, Miroslava" . . "Ruether, A." . "Nielsen, F." . "European Journal of Human Genetics" . "Palo, J." . "Gieger, C." . "Wichmann, HE" . . "Kouvatsi, A." .