. "1211-7579" . . . "Molecular-genetic analysis of Alzheimer's dementia in Czech population II: The variabilty of apolipoprotein E /Apo E/ gene"@en . . . "RIV/00216208:11120/97:43907300" . "804841" . "P(IZ2888)" . . "V t\u00E9to studii je prok\u00E1z\u00E1n v\u00FDznam genu pro apolipoprotein E v expresi Alzheimerovy demence /AD/ v \u010Desk\u00E9 populaci, p\u0159edev\u0161\u00EDm pak isoformy apolipoproteinu e4 /Apo e4/. Porovn\u00E1n\u00ED p\u0159\u00EDtomnosti alely Apo e4 u osob s Alzheimerovou demenc\u00ED a u osob kontroln\u00ED skupiny jednozna\u010Dn\u011B ukazuje zv\u00FD\u0161enou alelickou frekvenci u AD - skupiny. K ur\u010Den\u00ED genotyp\u00F9 obou skupin byla pou\u017Eita metoda polymer\u00E1zov\u00E9 \u0159et\u011Bzov\u00E9 reakce /PCR/ s n\u00E1slednou restrik\u010Dn\u00ED anal\u00FDzou. Je tedy velmi pravd\u011Bpodobn\u00E9, \u017Ee existence isoformy alely apolipoproteinu e4 v homozygotick\u00E9 \u010Di heterozygotick\u00E9 form\u011B by mohla b\u00FDt rizikov\u00FDm faktorem p\u0159i vzniku Alzheimerovy demence."@cs . "2" . . "Psychiatrie" . . . "1" . "V t\u00E9to studii je prok\u00E1z\u00E1n v\u00FDznam genu pro apolipoprotein E v expresi Alzheimerovy demence /AD/ v \u010Desk\u00E9 populaci, p\u0159edev\u0161\u00EDm pak isoformy apolipoproteinu e4 /Apo e4/. Porovn\u00E1n\u00ED p\u0159\u00EDtomnosti alely Apo e4 u osob s Alzheimerovou demenc\u00ED a u osob kontroln\u00ED skupiny jednozna\u010Dn\u011B ukazuje zv\u00FD\u0161enou alelickou frekvenci u AD - skupiny. K ur\u010Den\u00ED genotyp\u00F9 obou skupin byla pou\u017Eita metoda polymer\u00E1zov\u00E9 \u0159et\u011Bzov\u00E9 reakce /PCR/ s n\u00E1slednou restrik\u010Dn\u00ED anal\u00FDzou. Je tedy velmi pravd\u011Bpodobn\u00E9, \u017Ee existence isoformy alely apolipoproteinu e4 v homozygotick\u00E9 \u010Di heterozygotick\u00E9 form\u011B by mohla b\u00FDt rizikov\u00FDm faktorem p\u0159i vzniku Alzheimerovy demence." . "Mazura, Ivan" . . "Jir\u00E1k, Roman" . "Molekul\u00E1rn\u011B genetick\u00E1 anal\u00FDza Alzheimerovy demence v \u010Desk\u00E9 populaci I: Genetick\u00E1 variabilita v genu pro apolipoprotein E /Apo E/"@cs . . "Molecular-genetic analysis of Alzheimer's dementia in Czech population II: The variabilty of apolipoprotein E /Apo E/ gene"@en . "This study demonstrates the significance of the apolipoprotein E gene and specifically the allele e4, for the expression of Alzheimer\u00B4s disease/AD/ in the Czech population. A comparison of the prevalence of the ApoE e4 in subjects with Alzheimer\u00B4s dementia and in normal controls shows an increased allele frequency in the AD group (0,41 in males and 0,47 in females vs 0,16 in a group of normal subjects with no history of Alzheimer\u00B4s disease). The genotypes have been determined using the polymerase chain reaction and restriction analysis. It is thus very likely that the presence of the ApoE allele e4 in homozygous and heterozygous form represents a risk factor for Alzheimer\u00B4s disease."@en . "Molekul\u00E1rn\u011B genetick\u00E1 anal\u00FDza Alzheimerovy demence v \u010Desk\u00E9 populaci I: Genetick\u00E1 variabilita v genu pro apolipoprotein E /Apo E/" . "[D8A7702110E0]" . "3"^^ . "2"^^ . . "Koukol\u00EDk, Franti\u0161ek" . "CZ - \u010Cesk\u00E1 republika" . . "Molekul\u00E1rn\u011B genetick\u00E1 anal\u00FDza Alzheimerovy demence v \u010Desk\u00E9 populaci I: Genetick\u00E1 variabilita v genu pro apolipoprotein E /Apo E/"@cs . . "11120" . "Alzheimer\u00B4s disease, apolipoprotein E, polymerase chain reaction"@en . . . "RIV/00216208:11120/97:43907300!RIV13-MZ0-11120___" . "3"^^ . "Molekul\u00E1rn\u011B genetick\u00E1 anal\u00FDza Alzheimerovy demence v \u010Desk\u00E9 populaci I: Genetick\u00E1 variabilita v genu pro apolipoprotein E /Apo E/" .