"9" . "Havlov\u00E1, Andrea" . "Faktory vedouc\u00ED k po\u0161kozen\u00ED a destrukci beta-bun\u011Bk Langerhansov\u00FDch ostr\u016Fvk\u016F pankreatu" . "60" . . . "Heneberg, Petr" . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "destruction; damage; Langerhans islands"@en . "\u010Cech\u00E1kov\u00E1, Marie" . "Faktory vedouc\u00ED k po\u0161kozen\u00ED a destrukci beta-bun\u011Bk Langerhansov\u00FDch ostr\u016Fvk\u016F pankreatu"@cs . . . "11120" . . . "Ve\u010De\u0159ov\u00E1, L\u00EDvia" . . . . "[25EA929A3C1E]" . "RIV/00216208:11120/14:43909192!RIV15-MSM-11120___" . "7"^^ . . . . "Faktory vedouc\u00ED k po\u0161kozen\u00ED a destrukci beta-bun\u011Bk Langerhansov\u00FDch ostr\u016Fvk\u016F pankreatu"@cs . . "N\u011Bmcov\u00E1, Vlasta" . "Mandys, V\u00E1clav" . "CZ - \u010Cesk\u00E1 republika" . . "Urbanov\u00E1, Jana" . . . "RIV/00216208:11120/14:43909192" . . "U pacient\u016F, u kter\u00FDch se manifestoval diabetes mellitus, doch\u00E1z\u00ED po m\u011Bs\u00EDc\u00EDch a\u017E desetilet\u00EDch trv\u00E1n\u00ED choroby k vyhasnut\u00ED sekrece inzulinu, co\u017E je t\u00E9m\u011B\u0159 jist\u00FDm znamen\u00EDm \u00FAbytku beta-bun\u011Bk Langerhansov\u00FDch ostr\u016Fvk\u016F. U na\u0161eho sledovan\u00E9ho souboru 30 pacient\u016F, kte\u0159\u00ED manifestovali chorobu mezi 30\u201345 roky a kte\u0159\u00ED byli diagnostikov\u00E1ni jako diabetici 2. typu, m\u00E1 po 30 letech trv\u00E1n\u00ED choroby polovina zachovanou nebo vy\u0161\u0161\u00ED sekreci inzulinu, druh\u00E1 polovina pak sekreci v\u00FDrazn\u011B sn\u00ED\u017Eenou nebo vyhaslou. Faktory, kter\u00E9 postihuj\u00ED beta-bu\u0148ky a vedou k jejich destrukci, m\u016F\u017Eeme shrnout do n\u00E1sleduj\u00EDc\u00EDch skupin: 1. Faktory chemick\u00E9: \u2013 faktory metabolick\u00E9: hyperglykemie a glukotoxicita, lipotoxicita, hypoxie, voln\u00E9 kysl\u00EDkov\u00E9 radik\u00E1ly, \u2013 faktory farmakologick\u00E9: antimikrobi\u00E1ln\u00ED prost\u0159edek pentamidin, antidepresiva typu SSRI, \u2013 faktory spojen\u00E9 s poruchou sekrece inzulinu: MODY typy diabetu \u2013 toxick\u00E9 l\u00E1tky ze zevn\u00EDho prost\u0159ed\u00ED: jed na krysy Vacor, streptozotocin, polychlorovan\u00E9 \u010Di polybromovan\u00E9 uhlovod\u00EDky. 2. Onemocn\u011Bn\u00ED zevn\u011B sekretorick\u00E9 \u010D\u00E1sti pankreatu: n\u00E1dorov\u00E1 infiltrace, vazivov\u00E1 infiltrace, chronick\u00E1 pankreatitis. 3. Infekce, z\u00E1n\u011Bt a autoimunita: \u2013 faktory virov\u00E9: Coxsackie viry, virus ch\u0159ipky H1N1, enteroviry. Z\u00E1n\u011Bty. Autoimunn\u00ED faktory p\u0159edstavuj\u00EDc\u00ED patogenetick\u00FD faktor diabetu 1. typu. V sou\u010Dasn\u00E9 dob\u011B pracujeme jak na specifikaci dal\u0161\u00EDch faktor\u016F vedouc\u00EDch k po\u0161kozen\u00ED beta-bun\u011Bk, tak na studiu pozn\u00E1n\u00ED jejich \u00FA\u010Dinku na bun\u011B\u010Dnou apopt\u00F3zu, respektive nekr\u00F3zu, a kone\u010Dn\u011B na definici ochrann\u00FDch faktor\u016F, kter\u00E9 by \u00FA\u010Dinky p\u016Fsoben\u00ED t\u011Bchto faktor\u016F sn\u00ED\u017Eily. S n\u00E1r\u016Fstem v\u011Bdomost\u00ED o mechanismech po\u0161kozen\u00ED a destrukce beta-bun\u011Bk se r\u00FDsuj\u00ED n\u00E1vrhy n\u011Bkter\u00FDch opat\u0159en\u00ED, kter\u00E1 by je mohla chr\u00E1nit. V na\u0161em p\u0159ehledu pod\u00E1v\u00E1me zestru\u010Dn\u011Bl\u00FD a s ohledem na rozsah \u010Dl\u00E1nku tak\u00E9 notn\u011B zjednodu\u0161en\u00FD p\u0159ehled n\u011Bkter\u00FDch znalost\u00ED, kter\u00E9 se po\u0161kozen\u00ED a destrukce beta-bun\u011Bk t\u00FDkaj\u00ED." . "Kov\u00E1\u0159, Jan" . . "Strakov\u00E1, Radka" . "Factors leading to damage and destruction of beta-cells of langerhans islands of pancreas"@en . "16432" . "Trnka, Jan" . "U pacient\u016F, u kter\u00FDch se manifestoval diabetes mellitus, doch\u00E1z\u00ED po m\u011Bs\u00EDc\u00EDch a\u017E desetilet\u00EDch trv\u00E1n\u00ED choroby k vyhasnut\u00ED sekrece inzulinu, co\u017E je t\u00E9m\u011B\u0159 jist\u00FDm znamen\u00EDm \u00FAbytku beta-bun\u011Bk Langerhansov\u00FDch ostr\u016Fvk\u016F. U na\u0161eho sledovan\u00E9ho souboru 30 pacient\u016F, kte\u0159\u00ED manifestovali chorobu mezi 30\u201345 roky a kte\u0159\u00ED byli diagnostikov\u00E1ni jako diabetici 2. typu, m\u00E1 po 30 letech trv\u00E1n\u00ED choroby polovina zachovanou nebo vy\u0161\u0161\u00ED sekreci inzulinu, druh\u00E1 polovina pak sekreci v\u00FDrazn\u011B sn\u00ED\u017Eenou nebo vyhaslou. Faktory, kter\u00E9 postihuj\u00ED beta-bu\u0148ky a vedou k jejich destrukci, m\u016F\u017Eeme shrnout do n\u00E1sleduj\u00EDc\u00EDch skupin: 1. Faktory chemick\u00E9: \u2013 faktory metabolick\u00E9: hyperglykemie a glukotoxicita, lipotoxicita, hypoxie, voln\u00E9 kysl\u00EDkov\u00E9 radik\u00E1ly, \u2013 faktory farmakologick\u00E9: antimikrobi\u00E1ln\u00ED prost\u0159edek pentamidin, antidepresiva typu SSRI, \u2013 faktory spojen\u00E9 s poruchou sekrece inzulinu: MODY typy diabetu \u2013 toxick\u00E9 l\u00E1tky ze zevn\u00EDho prost\u0159ed\u00ED: jed na krysy Vacor, streptozotocin, polychlorovan\u00E9 \u010Di polybromovan\u00E9 uhlovod\u00EDky. 2. Onemocn\u011Bn\u00ED zevn\u011B sekretorick\u00E9 \u010D\u00E1sti pankreatu: n\u00E1dorov\u00E1 infiltrace, vazivov\u00E1 infiltrace, chronick\u00E1 pankreatitis. 3. Infekce, z\u00E1n\u011Bt a autoimunita: \u2013 faktory virov\u00E9: Coxsackie viry, virus ch\u0159ipky H1N1, enteroviry. Z\u00E1n\u011Bty. Autoimunn\u00ED faktory p\u0159edstavuj\u00EDc\u00ED patogenetick\u00FD faktor diabetu 1. typu. V sou\u010Dasn\u00E9 dob\u011B pracujeme jak na specifikaci dal\u0161\u00EDch faktor\u016F vedouc\u00EDch k po\u0161kozen\u00ED beta-bun\u011Bk, tak na studiu pozn\u00E1n\u00ED jejich \u00FA\u010Dinku na bun\u011B\u010Dnou apopt\u00F3zu, respektive nekr\u00F3zu, a kone\u010Dn\u011B na definici ochrann\u00FDch faktor\u016F, kter\u00E9 by \u00FA\u010Dinky p\u016Fsoben\u00ED t\u011Bchto faktor\u016F sn\u00ED\u017Eily. S n\u00E1r\u016Fstem v\u011Bdomost\u00ED o mechanismech po\u0161kozen\u00ED a destrukce beta-bun\u011Bk se r\u00FDsuj\u00ED n\u00E1vrhy n\u011Bkter\u00FDch opat\u0159en\u00ED, kter\u00E1 by je mohla chr\u00E1nit. V na\u0161em p\u0159ehledu pod\u00E1v\u00E1me zestru\u010Dn\u011Bl\u00FD a s ohledem na rozsah \u010Dl\u00E1nku tak\u00E9 notn\u011B zjednodu\u0161en\u00FD p\u0159ehled n\u011Bkter\u00FDch znalost\u00ED, kter\u00E9 se po\u0161kozen\u00ED a destrukce beta-bun\u011Bk t\u00FDkaj\u00ED."@cs . "Insulin secretion in patients with manifested diabetes mellitus tends to disappear months to decades after the diagnosis, which is a clear sign of a gradual loss of pancreatic islet beta-cells. In our sample of 30 type 2 diabetic patients, whose disease manifested between 30 and 45 years of age, about a half have retained or even increased insulin secretion 30 years later, while the other half exhibit a much diminished or lost insulin secretion. Factors that can damage or destroy beta-cells can be divided into the following groups: Metabolic factors: hyperglycemia and glucotoxicity, lipotoxicity, hypoxia, reactive oxygen species; Pharmacological factors: antimicrobial medication pentamidine, SSRI antidepressants; Factors realted to impaired insulin secretion: MODY type diabetes; Environmental toxic factors: rat poison Vacor, streptozotocin, polychlorinated and polybrominated hydrocarbons; Disorders of the exocrine pancreas: tumor infiltration, fibroous infiltration, chronic pancreatitis, cystic fibrosis; Infections, inflammation, autoimmunity, viral factors: Coxsackie viruses, H1N1 influenza, enteroviruses. We are currently working on finding other factors leading to beta-cell damage, studying their effect on apoptosis and necrosis and looking for possible protective factors to prevent this damage. We our increasing knowledge about the mechanisms of beta-cell damage and destruction we come ever closer to suggest measures for their prevention. In this review we offer a brief and simplified summary of some of the findings related to this area."@en . "Factors leading to damage and destruction of beta-cells of langerhans islands of pancreas"@en . . "13"^^ . "Faktory vedouc\u00ED k po\u0161kozen\u00ED a destrukci beta-bun\u011Bk Langerhansov\u00FDch ostr\u016Fvk\u016F pankreatu" . "0042-773X" . "Pavl\u00EDkov\u00E1, Nela" . . "I" . . "And\u011Bl, Michal" . "Pol\u00E1k, Jan" . . . . . "13"^^ .