"3" . "The primary aim of the present paper was to assess how much is this extension of contraindication of codeine use to adults substantiated by published reports. The secondary aim was to find reports on respiratory depression after dihydrocodeine. Conclusions: The extension of contraindication of codeine use to adults because of increased risk of respiratory depression in CYP2D6 ultrarapid metabolizers is not substantiated by the current publications available in PubMed or Web of Science (with the exception of breastfeeding mothers). In contrast, there is a good evidence for increased risk of respiratory depression after codeine in children CYP2D6 ultrarapid metabolizers. No evidence was found for respiratory depression after dihydrocodeine."@en . . "Hlavn\u00EDm c\u00EDlem t\u00E9to pr\u00E1ce bylo zjistit, do jak\u00E9 m\u00EDry je roz\u0161\u00ED\u0159en\u00ED kontraindikace pod\u00E1v\u00E1n\u00ED kodeinu i na dosp\u011Bl\u00E9 opodstatn\u011Bn\u00E9 \u00FAdaji v odborn\u00E9 literatu\u0159e. Dopl\u0148kov\u00FDm c\u00EDlem bylo nal\u00E9zt v literatu\u0159e doklady o \u00FAtlumu respirace po dihydrokodeinu. Z\u00E1v\u011Br: Roz\u0161\u00ED\u0159en\u00ED kontraindikace kodeinu i na dosp\u011Bl\u00E9 ultrarychl\u00E9 metaboliz\u00E9ry CYP2D6 navr\u017Een\u00E9 v\u00FDbory EMA nen\u00ED zat\u00EDm podlo\u017Eeno dostate\u010Dn\u00FDmi fakty (s v\u00FDjimkou koj\u00EDc\u00EDch \u017Een). Naproti tomu u ultrarychl\u00FDch metaboliz\u00E9r\u00F9 CYP2D6 v d\u011Btsk\u00E9m v\u011Bku je riziko z\u00E1va\u017En\u00E9ho \u00FAtlumu respirace po kodeinu dob\u0159e dolo\u017Eeno. U d\u011Bt\u00ED, zejm\u00E9na u kojenc\u00F9, pravd\u011Bpodobn\u011B p\u0159evl\u00E1d\u00E1 p\u0159em\u011Bna kodeinu prost\u0159ednictv\u00EDm CYP2D6 na morfin, zat\u00EDmco ostatn\u00ED elimina\u010Dn\u00ED metabolick\u00E9 mechanismy kodeinu je\u0161t\u011B nejsou pln\u011B vyvinuty. Nebyly nalezeny doklady o \u00FAtlumu respirace po dihydrokodeinu."@cs . "17" . "[0760A1DCAC08]" . . . "European Medicines Agency; CYP2D6 ultrarapid metabolizers; dihydrocodeine; codeine; respiratory depression"@en . "RIV/00216208:11120/14:43909191!RIV15-MSM-11120___" . . "Toward the risk of respiration depression after codeine and dihydrocodeine"@en . "Hlavn\u00EDm c\u00EDlem t\u00E9to pr\u00E1ce bylo zjistit, do jak\u00E9 m\u00EDry je roz\u0161\u00ED\u0159en\u00ED kontraindikace pod\u00E1v\u00E1n\u00ED kodeinu i na dosp\u011Bl\u00E9 opodstatn\u011Bn\u00E9 \u00FAdaji v odborn\u00E9 literatu\u0159e. Dopl\u0148kov\u00FDm c\u00EDlem bylo nal\u00E9zt v literatu\u0159e doklady o \u00FAtlumu respirace po dihydrokodeinu. Z\u00E1v\u011Br: Roz\u0161\u00ED\u0159en\u00ED kontraindikace kodeinu i na dosp\u011Bl\u00E9 ultrarychl\u00E9 metaboliz\u00E9ry CYP2D6 navr\u017Een\u00E9 v\u00FDbory EMA nen\u00ED zat\u00EDm podlo\u017Eeno dostate\u010Dn\u00FDmi fakty (s v\u00FDjimkou koj\u00EDc\u00EDch \u017Een). Naproti tomu u ultrarychl\u00FDch metaboliz\u00E9r\u00F9 CYP2D6 v d\u011Btsk\u00E9m v\u011Bku je riziko z\u00E1va\u017En\u00E9ho \u00FAtlumu respirace po kodeinu dob\u0159e dolo\u017Eeno. U d\u011Bt\u00ED, zejm\u00E9na u kojenc\u00F9, pravd\u011Bpodobn\u011B p\u0159evl\u00E1d\u00E1 p\u0159em\u011Bna kodeinu prost\u0159ednictv\u00EDm CYP2D6 na morfin, zat\u00EDmco ostatn\u00ED elimina\u010Dn\u00ED metabolick\u00E9 mechanismy kodeinu je\u0161t\u011B nejsou pln\u011B vyvinuty. Nebyly nalezeny doklady o \u00FAtlumu respirace po dihydrokodeinu." . "RIV/00216208:11120/14:43909191" . "CZ - \u010Cesk\u00E1 republika" . . . "K riziku \u00FAtlumu respirace po kodeinu a dihydrokodeinu" . . "Bolest" . . "I" . "Kr\u0161iak, Miloslav" . "4"^^ . . "Toward the risk of respiration depression after codeine and dihydrocodeine"@en . "1212-0634" . . "K riziku \u00FAtlumu respirace po kodeinu a dihydrokodeinu"@cs . . "11120" . . "23830" . "K riziku \u00FAtlumu respirace po kodeinu a dihydrokodeinu" . . . "1"^^ . "1"^^ . . "K riziku \u00FAtlumu respirace po kodeinu a dihydrokodeinu"@cs . .