"Osteoporosis and bone alterations in adult celiac disease"@en . . "Celiakie je spojena s vysok\u00FDm rizikem rozvoje sekund\u00E1rn\u00ED osteopor\u00F3zy. Osteopor\u00F3za nebo osteopenie jsou typicky p\u0159\u00EDtomny u nel\u00E9\u010Den\u00FDch celiak\u00E1ln\u00EDch pacient\u016F se zjevn\u00FDm malabsorp\u010Dn\u00EDm syndromem, jsou v\u0161ak prokazateln\u00E9 i u neoptim\u00E1ln\u011B l\u00E9\u010Den\u00FDch pacient\u016F \u010Di u jedinc\u016F se subklinickou a asymptomatickou formou celiakie. Etiologie kostn\u00EDch zm\u011Bn u celiakie je multifaktori\u00E1ln\u00ED, zahrnuje v\u0161ak 2 hlavn\u00ED patofyziologick\u00E9 mechanizmy: st\u0159evn\u00ED malabsorpci a chronick\u00FD z\u00E1n\u011Bt. Vyhodnocen\u00ED kostn\u00EDho miner\u00E1lov\u00E9ho metabolizmu (vy\u0161et\u0159en\u00ED pom\u011Bru s\u00E9rov\u00E9 hladiny celkov\u00E9ho kalcia a albuminu, s\u00E9rov\u00E9 hladiny 25-OH D3 vitaminu a parathormonu) a denzitometrick\u00E9 vy\u0161et\u0159en\u00ED se u celiak\u00E1ln\u00EDch pacient\u016F doporu\u010Duje jako sou\u010D\u00E1st klinick\u00E9 p\u00E9\u010De nutn\u00E9 k nastaven\u00ED optim\u00E1ln\u00ED terapie. \u0158ada studi\u00ED uk\u00E1zala, \u017Ee u dosp\u011Bl\u00FDch celiak\u016F doch\u00E1z\u00ED ke zlep\u0161en\u00ED kostn\u00ED miner\u00E1lov\u00E9 denzity zejm\u00E9na v \u010Dasn\u00E9m obdob\u00ED po zaveden\u00ED striktn\u00ED bezlepkov\u00E9 diety, v dal\u0161\u00EDm pr\u016Fb\u011Bhu v\u0161ak nen\u00ED jej\u00ED efekt ve v\u0161ech p\u0159\u00EDpadech dostate\u010Dn\u00FD, a tak by se m\u011Bla v indikovan\u00FDch p\u0159\u00EDpadech zv\u00E1\u017Eit i medikament\u00F3zn\u00ED l\u00E9\u010Dba osteopor\u00F3zy. Z klinick\u00E9 praxe v\u0161ak v\u00EDme, \u017Ee p\u00E9\u010De o kostn\u00ED zdrav\u00ED celiak\u00E1ln\u00EDch pacient\u016F nen\u00ED v\u017Edy optim\u00E1ln\u00ED." . . "malabsorption; intestinal inflamation; osteoporosis; gluten-free diet; densitometry; celiac disease; bone mineral metabolism; bone mineral density"@en . . "And\u011Bl, Michal" . . "Osteopor\u00F3za a metabolick\u00E9 kostn\u00ED zm\u011Bny u celiakie" . "Osteopor\u00F3za a metabolick\u00E9 kostn\u00ED zm\u011Bny u celiakie" . "Celiakie je spojena s vysok\u00FDm rizikem rozvoje sekund\u00E1rn\u00ED osteopor\u00F3zy. Osteopor\u00F3za nebo osteopenie jsou typicky p\u0159\u00EDtomny u nel\u00E9\u010Den\u00FDch celiak\u00E1ln\u00EDch pacient\u016F se zjevn\u00FDm malabsorp\u010Dn\u00EDm syndromem, jsou v\u0161ak prokazateln\u00E9 i u neoptim\u00E1ln\u011B l\u00E9\u010Den\u00FDch pacient\u016F \u010Di u jedinc\u016F se subklinickou a asymptomatickou formou celiakie. Etiologie kostn\u00EDch zm\u011Bn u celiakie je multifaktori\u00E1ln\u00ED, zahrnuje v\u0161ak 2 hlavn\u00ED patofyziologick\u00E9 mechanizmy: st\u0159evn\u00ED malabsorpci a chronick\u00FD z\u00E1n\u011Bt. Vyhodnocen\u00ED kostn\u00EDho miner\u00E1lov\u00E9ho metabolizmu (vy\u0161et\u0159en\u00ED pom\u011Bru s\u00E9rov\u00E9 hladiny celkov\u00E9ho kalcia a albuminu, s\u00E9rov\u00E9 hladiny 25-OH D3 vitaminu a parathormonu) a denzitometrick\u00E9 vy\u0161et\u0159en\u00ED se u celiak\u00E1ln\u00EDch pacient\u016F doporu\u010Duje jako sou\u010D\u00E1st klinick\u00E9 p\u00E9\u010De nutn\u00E9 k nastaven\u00ED optim\u00E1ln\u00ED terapie. \u0158ada studi\u00ED uk\u00E1zala, \u017Ee u dosp\u011Bl\u00FDch celiak\u016F doch\u00E1z\u00ED ke zlep\u0161en\u00ED kostn\u00ED miner\u00E1lov\u00E9 denzity zejm\u00E9na v \u010Dasn\u00E9m obdob\u00ED po zaveden\u00ED striktn\u00ED bezlepkov\u00E9 diety, v dal\u0161\u00EDm pr\u016Fb\u011Bhu v\u0161ak nen\u00ED jej\u00ED efekt ve v\u0161ech p\u0159\u00EDpadech dostate\u010Dn\u00FD, a tak by se m\u011Bla v indikovan\u00FDch p\u0159\u00EDpadech zv\u00E1\u017Eit i medikament\u00F3zn\u00ED l\u00E9\u010Dba osteopor\u00F3zy. Z klinick\u00E9 praxe v\u0161ak v\u00EDme, \u017Ee p\u00E9\u010De o kostn\u00ED zdrav\u00ED celiak\u00E1ln\u00EDch pacient\u016F nen\u00ED v\u017Edy optim\u00E1ln\u00ED."@cs . . . "2"^^ . "6"^^ . "0042-773X" . . "Osteopor\u00F3za a metabolick\u00E9 kostn\u00ED zm\u011Bny u celiakie"@cs . "11120" . "2"^^ . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . "60" . "RIV/00216208:11120/14:43908877!RIV15-MSM-11120___" . . . "I" . . "[5E6695CBD0D9]" . . . "Hoffmanov\u00E1, Iva" . . "RIV/00216208:11120/14:43908877" . "Osteoporosis and bone alterations in adult celiac disease"@en . "35269" . . . . "CZ - \u010Cesk\u00E1 republika" . . . . "Both celiac disease and osteoporosis are common diseases which are considered an emerging problem in medicine. Celiac disease is a condition at high risk for secondary osteoporosis. Osteoporosis or osteopenia are typically present in untreated adult symptomatic celiac disease with an overt malabsorption syndrome, but is found in about 50 % in suboptimally treated celiac patients, subclinical patients and asymptomatic adult celiac patients, too. Etiology of pathologic bone alteration in celiac disease is multifactorial; however, two main mechanisms are involved: intestinal malabsorption and chronic inflammation. The evaluation of bone mineral metabolism (total calcium/albumin, 25-OH vitamin D3 and parathormone levels in serum) and bone mineral density (densitometry) is recommended in the clinical management of celiac patients. Many studies have demonstrated that bone mineral density values in adults show a good improvement in the first period after the institution of gluten-free diet, the improvement is then unsatisfactory and treatment with a mineral-active drug should probably be considered."@en . "Osteopor\u00F3za a metabolick\u00E9 kostn\u00ED zm\u011Bny u celiakie"@cs . . "7-8" .