. "P(NT13708)" . . "Gastroenterologie a hepatologie" . "[748E963023B3]" . "RIV/00216208:11120/13:43908340" . . . "CZ - \u010Cesk\u00E1 republika" . "5"^^ . "rat; an animal model; perianal fistula"@en . "Matou\u0161kov\u00E1, Eva" . "74186" . "Experimental model of perianal fistula in a small laboratory animal"@en . "Experiment\u00E1ln\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble na mal\u00E9m laboratorn\u00EDm zv\u00ED\u0159eti"@cs . . "5"^^ . "67" . "RIV/00216208:11120/13:43908340!RIV14-MZ0-11120___" . . . "Experiment\u00E1ln\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble na mal\u00E9m laboratorn\u00EDm zv\u00ED\u0159eti" . . "Perian\u00E1ln\u00ED p\u00ED\u0161t\u011Bl je \u010Dast\u00E9 onemocn\u011Bn\u00ED vy\u017Eaduj\u00EDc\u00ED chirurgickou intervenci. V sou\u010Dasn\u00E9 dob\u011B jsou p\u0159edm\u011Btem v\u00FDzkumu nov\u00E9 alternativn\u00ED terapeutick\u00E9 metody (transplantace mezenchym\u00E1ln\u00EDch bun\u011Bk, aplikace fibrinov\u00FDch lepidel nebo z\u00E1tek \u2013 plug\u016F). K ov\u011B\u0159en\u00ED \u00FA\u010Dinnosti t\u011Bchto technik v experimentu je pot\u0159ebn\u00FD vhodn\u00FD model na laboratorn\u00EDm zv\u00ED\u0159eti. C\u00EDlem pr\u00E1ce bylo vytvo\u0159it klinicky adekv\u00E1tn\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble umo\u017E\u0148uj\u00EDc\u00ED hodnocen\u00ED nov\u00FDch terapeutick\u00FDch metod. Metody: U 30 potkan\u016F kmene Wistar byla provedena axi\u00E1ln\u00ED c\u00E9kostomie s prota\u017Een\u00EDm c\u00E9ka 2,5 cm dlouh\u00FDm podko\u017En\u00EDm kan\u00E1lem simuluj\u00EDc\u00EDm trakt p\u00ED\u0161t\u011Ble. Po 40denn\u00EDm sledov\u00E1n\u00ED byla zv\u00ED\u0159ata randomizov\u00E1na do t\u0159\u00ED skupin. V prvn\u00ED skupin\u011B byla p\u00ED\u0161t\u011Bl o\u0161et\u0159ena pomoc\u00ED sutury \u00FAst\u00ED, ve druh\u00E9 skupin\u011B pomoc\u00ED podvazu traktu p\u00ED\u0161t\u011Ble, t\u0159et\u00ED skupina byla kontroln\u00ED bez intervence. V\u00FDsledky: Model byl technicky provediteln\u00FD u v\u0161ech zv\u00ED\u0159at v pr\u016Fm\u011Brn\u00E9m opera\u010Dn\u00EDm \u010Dase 22 (? 5,1) min. B\u011Bhem 40denn\u00EDho sledov\u00E1n\u00ED dv\u011B zv\u00ED\u0159ata (7 %) uhynula prvn\u00ED a p\u00E1t\u00FD den po zalo\u017Een\u00ED c\u00E9kostomie a u jednoho zv\u00ED\u0159ete (3 %) do\u0161lo ke spont\u00E1nn\u00EDmu zhojen\u00ED p\u00ED\u0161t\u011Ble. Randomizov\u00E1no bylo tedy celkem 27 zv\u00ED\u0159at. Ve skupin\u00E1ch se suturou \u00FAst\u00ED (n = 9), podvazem traktu p\u00ED\u0161t\u011Ble (n = 12) a kontroln\u00ED skupin\u011B (n = 6) do\u0161lo ke zhojen\u00ED u t\u0159\u00ED (33 %), \u0161esti (50 %) a 0 (0 %) zv\u00ED\u0159at. V\u00FDsledky v interven\u010Dn\u00EDch skupin\u00E1ch jsou ve shod\u011B s v\u00FDsledky klinick\u00FDch studi\u00ED. Z\u00E1v\u011Br: V experiment\u00E1ln\u00ED pr\u00E1ci byl vytvo\u0159en klinicky adekv\u00E1tn\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble vhodn\u00FD pro hodnocen\u00ED nov\u00FDch l\u00E9\u010Debn\u00FDch metod."@cs . "Experiment\u00E1ln\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble na mal\u00E9m laboratorn\u00EDm zv\u00ED\u0159eti"@cs . . . "1"^^ . "http://www.csgh.info/dwnld/gh_2013_4_298_302.pdf" . "Perian\u00E1ln\u00ED p\u00ED\u0161t\u011Bl je \u010Dast\u00E9 onemocn\u011Bn\u00ED vy\u017Eaduj\u00EDc\u00ED chirurgickou intervenci. V sou\u010Dasn\u00E9 dob\u011B jsou p\u0159edm\u011Btem v\u00FDzkumu nov\u00E9 alternativn\u00ED terapeutick\u00E9 metody (transplantace mezenchym\u00E1ln\u00EDch bun\u011Bk, aplikace fibrinov\u00FDch lepidel nebo z\u00E1tek \u2013 plug\u016F). K ov\u011B\u0159en\u00ED \u00FA\u010Dinnosti t\u011Bchto technik v experimentu je pot\u0159ebn\u00FD vhodn\u00FD model na laboratorn\u00EDm zv\u00ED\u0159eti. C\u00EDlem pr\u00E1ce bylo vytvo\u0159it klinicky adekv\u00E1tn\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble umo\u017E\u0148uj\u00EDc\u00ED hodnocen\u00ED nov\u00FDch terapeutick\u00FDch metod. Metody: U 30 potkan\u016F kmene Wistar byla provedena axi\u00E1ln\u00ED c\u00E9kostomie s prota\u017Een\u00EDm c\u00E9ka 2,5 cm dlouh\u00FDm podko\u017En\u00EDm kan\u00E1lem simuluj\u00EDc\u00EDm trakt p\u00ED\u0161t\u011Ble. Po 40denn\u00EDm sledov\u00E1n\u00ED byla zv\u00ED\u0159ata randomizov\u00E1na do t\u0159\u00ED skupin. V prvn\u00ED skupin\u011B byla p\u00ED\u0161t\u011Bl o\u0161et\u0159ena pomoc\u00ED sutury \u00FAst\u00ED, ve druh\u00E9 skupin\u011B pomoc\u00ED podvazu traktu p\u00ED\u0161t\u011Ble, t\u0159et\u00ED skupina byla kontroln\u00ED bez intervence. V\u00FDsledky: Model byl technicky provediteln\u00FD u v\u0161ech zv\u00ED\u0159at v pr\u016Fm\u011Brn\u00E9m opera\u010Dn\u00EDm \u010Dase 22 (? 5,1) min. B\u011Bhem 40denn\u00EDho sledov\u00E1n\u00ED dv\u011B zv\u00ED\u0159ata (7 %) uhynula prvn\u00ED a p\u00E1t\u00FD den po zalo\u017Een\u00ED c\u00E9kostomie a u jednoho zv\u00ED\u0159ete (3 %) do\u0161lo ke spont\u00E1nn\u00EDmu zhojen\u00ED p\u00ED\u0161t\u011Ble. Randomizov\u00E1no bylo tedy celkem 27 zv\u00ED\u0159at. Ve skupin\u00E1ch se suturou \u00FAst\u00ED (n = 9), podvazem traktu p\u00ED\u0161t\u011Ble (n = 12) a kontroln\u00ED skupin\u011B (n = 6) do\u0161lo ke zhojen\u00ED u t\u0159\u00ED (33 %), \u0161esti (50 %) a 0 (0 %) zv\u00ED\u0159at. V\u00FDsledky v interven\u010Dn\u00EDch skupin\u00E1ch jsou ve shod\u011B s v\u00FDsledky klinick\u00FDch studi\u00ED. Z\u00E1v\u011Br: V experiment\u00E1ln\u00ED pr\u00E1ci byl vytvo\u0159en klinicky adekv\u00E1tn\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble vhodn\u00FD pro hodnocen\u00ED nov\u00FDch l\u00E9\u010Debn\u00FDch metod." . "4" . . "Experimental model of perianal fistula in a small laboratory animal"@en . "Perianal fistula is a common disease usually requiring surgical interventions. New alternative therapeutic methods (stem cells transplantation, fibrin glue, fistula plug) are currently investigated. A suitable animal model is needed to evaluate the effect of these techniques in an experimental study. The aim of this study was to create a clinically adequate model of perianal fistula applicable in the evaluation of new therapeutic methods. Methods: Axial caecostomy with 2.5 cm subcutaneous channel was performed in 30 Wistar rats. After the 40-day follow-up, the animals were randomized into three groups. The first group was treated with suture to the fistula opening the second group by fistula tract ligation, and the third was a control group without intervention. Results: The model was technically feasible in all animals with an average operating time 22 (? 5.1) mins. During the 40-day observation two animals (7%) died on the first and fifth postoperative day, and one animal (3%) had spontaneous fistula \u00ADhealing. In total, 27 animals were randomized. In groups with opening suture (n = 9), tract ligation (n = 12) and in control group (n = 8) fistula healing was observed in three (33%), six (50%) and 0 (0%) animals. Results in interventional groups were in agreement with results of clinical trials. Conclusion: A clinically adequate model of perianal fistulas suitable for the evaluation of new treatment techniques was created."@en . "11120" . . . . "Experiment\u00E1ln\u00ED model perian\u00E1ln\u00ED p\u00ED\u0161t\u011Ble na mal\u00E9m laboratorn\u00EDm zv\u00ED\u0159eti" . . "1804-7874" . .