"Food intake regulation -2nd part"@en . "Regulace p\u0159\u00EDjmu potravy - II. \u010D\u00E1st" . "serotonin; opioids; endocannabinoids; dopamine; reward circuits; hedonic regulation"@en . "102053" . "\u010Cl\u00E1nek shrnuje principy h\u00E9donick\u00E9 regulace p\u0159\u00EDjmu potravy, kter\u00E1 reprezentuje p\u0159\u00EDjem potravy nez\u00E1visl\u00FD na udr\u017Een\u00ED homeost\u00E1zy. Teorie popisuj\u00EDc\u00ED h\u00E9donickou regulaci, tzv. teorie senzitizace v\u016F\u010Di podn\u011Btu, zahrnuje t\u0159i procesy: vytvo\u0159en\u00ED pozitivn\u00EDho vztahu k potravn\u00EDmu podn\u011Btu (liking), motivaci z\u00EDskat ho (wanting) a nau\u010Dit se tyto podn\u011Bty identifikovat a odli\u0161it od jin\u00FDch, jejich\u017E konzumace naopak vyvol\u00E1 averzn\u00ED reakci (learning). Anatomick\u00FDm a funk\u010Dn\u00EDm substr\u00E1tem h\u00E9donick\u00E9 regulace jsou neuron\u00E1ln\u00ED okruhy odm\u011Bny (reward circuits), kter\u00E9 reaguj\u00ED na chu\u0165ov\u00E9, \u010Dichov\u00E9 (\u010Di zrakov\u00E9) podn\u011Bty spojen\u00E9 s p\u0159\u00EDjmem potravy. Preference ur\u010Dit\u00E9 potravy nastane pouze v p\u0159\u00EDpad\u011B, \u017Ee je jej\u00ED konzumace spojena s p\u0159\u00EDjemn\u00FDm pocitem, kter\u00FD posiluje behavior\u00E1ln\u00ED odpov\u011B\u010F, tak\u017Ee pravd\u011Bpodobnost t\u00E9to odpov\u011Bdi je p\u0159i opakovan\u00E9 expozici takov\u00E9mu podn\u011Btu zv\u00FD\u0161en\u00E1 (nau\u010Den\u00E1 preference). Naopak nau\u010Den\u00E1 averze spo\u010D\u00EDv\u00E1 p\u0159i opakovan\u00E9 expozici ve vyh\u00FDb\u00E1n\u00ED se potrav\u011B, kter\u00E1 byla spojena s negativn\u00EDm pocitem. Hlavn\u00EDmi medi\u00E1tory h\u00E9donick\u00E9 regulace jsou endokanabinoidy, opiody a monoaminy (zvl\u00E1\u0161t\u011B dopamin a m\u00E9n\u011B serotonin). Dopamin prost\u0159ednictv\u00EDm sv\u00FDch D2 receptor\u016F generuje v dorz\u00E1ln\u00EDm striatu motivaci k j\u00EDdlu jako jednoho ze z\u00E1kladn\u00EDch prost\u0159edk\u016F p\u0159e\u017Eit\u00ED, zat\u00EDmco ve ventr\u00E1ln\u00EDm striatu (nucleus accumbens) zodpov\u00EDd\u00E1 sp\u00ED\u0161e za motivaci k j\u00EDdlu p\u0159in\u00E1\u0161ej\u00EDc\u00EDmu lib\u00E9 pocity. Serotonin p\u0159es sv\u00E9 receptory 5-HT1A a 5-HT2C sni\u017Euje p\u0159\u00EDjem zvl\u00E1\u0161t\u011B chutn\u00E9 potravy. Hraje tak\u00E9 v\u00FDznamnou \u00FAlohu v patogenezi poruch p\u0159\u00EDjmu potravy. U ment\u00E1ln\u00ED anorexie p\u0159edstavuje restrikce potravy ur\u010Ditou automedikaci patologicky zv\u00FD\u0161en\u00FDch hladin serotoninu. Kl\u00ED\u010Dem k nov\u00FDm farmakoterapeutick\u00FDm intervenc\u00EDm poruch p\u0159\u00EDjmu potravy je detailn\u00ED pochopen\u00ED proces\u016F, jak\u00FDmi je p\u0159\u00EDjem potravy regulov\u00E1n"@cs . . . . . "2"^^ . "\u010Cl\u00E1nek shrnuje principy h\u00E9donick\u00E9 regulace p\u0159\u00EDjmu potravy, kter\u00E1 reprezentuje p\u0159\u00EDjem potravy nez\u00E1visl\u00FD na udr\u017Een\u00ED homeost\u00E1zy. Teorie popisuj\u00EDc\u00ED h\u00E9donickou regulaci, tzv. teorie senzitizace v\u016F\u010Di podn\u011Btu, zahrnuje t\u0159i procesy: vytvo\u0159en\u00ED pozitivn\u00EDho vztahu k potravn\u00EDmu podn\u011Btu (liking), motivaci z\u00EDskat ho (wanting) a nau\u010Dit se tyto podn\u011Bty identifikovat a odli\u0161it od jin\u00FDch, jejich\u017E konzumace naopak vyvol\u00E1 averzn\u00ED reakci (learning). Anatomick\u00FDm a funk\u010Dn\u00EDm substr\u00E1tem h\u00E9donick\u00E9 regulace jsou neuron\u00E1ln\u00ED okruhy odm\u011Bny (reward circuits), kter\u00E9 reaguj\u00ED na chu\u0165ov\u00E9, \u010Dichov\u00E9 (\u010Di zrakov\u00E9) podn\u011Bty spojen\u00E9 s p\u0159\u00EDjmem potravy. Preference ur\u010Dit\u00E9 potravy nastane pouze v p\u0159\u00EDpad\u011B, \u017Ee je jej\u00ED konzumace spojena s p\u0159\u00EDjemn\u00FDm pocitem, kter\u00FD posiluje behavior\u00E1ln\u00ED odpov\u011B\u010F, tak\u017Ee pravd\u011Bpodobnost t\u00E9to odpov\u011Bdi je p\u0159i opakovan\u00E9 expozici takov\u00E9mu podn\u011Btu zv\u00FD\u0161en\u00E1 (nau\u010Den\u00E1 preference). Naopak nau\u010Den\u00E1 averze spo\u010D\u00EDv\u00E1 p\u0159i opakovan\u00E9 expozici ve vyh\u00FDb\u00E1n\u00ED se potrav\u011B, kter\u00E1 byla spojena s negativn\u00EDm pocitem. Hlavn\u00EDmi medi\u00E1tory h\u00E9donick\u00E9 regulace jsou endokanabinoidy, opiody a monoaminy (zvl\u00E1\u0161t\u011B dopamin a m\u00E9n\u011B serotonin). Dopamin prost\u0159ednictv\u00EDm sv\u00FDch D2 receptor\u016F generuje v dorz\u00E1ln\u00EDm striatu motivaci k j\u00EDdlu jako jednoho ze z\u00E1kladn\u00EDch prost\u0159edk\u016F p\u0159e\u017Eit\u00ED, zat\u00EDmco ve ventr\u00E1ln\u00EDm striatu (nucleus accumbens) zodpov\u00EDd\u00E1 sp\u00ED\u0161e za motivaci k j\u00EDdlu p\u0159in\u00E1\u0161ej\u00EDc\u00EDmu lib\u00E9 pocity. Serotonin p\u0159es sv\u00E9 receptory 5-HT1A a 5-HT2C sni\u017Euje p\u0159\u00EDjem zvl\u00E1\u0161t\u011B chutn\u00E9 potravy. Hraje tak\u00E9 v\u00FDznamnou \u00FAlohu v patogenezi poruch p\u0159\u00EDjmu potravy. U ment\u00E1ln\u00ED anorexie p\u0159edstavuje restrikce potravy ur\u010Ditou automedikaci patologicky zv\u00FD\u0161en\u00FDch hladin serotoninu. Kl\u00ED\u010Dem k nov\u00FDm farmakoterapeutick\u00FDm intervenc\u00EDm poruch p\u0159\u00EDjmu potravy je detailn\u00ED pochopen\u00ED proces\u016F, jak\u00FDmi je p\u0159\u00EDjem potravy regulov\u00E1n" . . "Food intake regulation -2nd part"@en . "[FB5CDB648D54]" . . . "And\u011Bl, Michal" . "RIV/00216208:11120/13:43907454" . . . "The article summarizes the principles of hedonic regulation of food intake which represents the food intake independent on the maintenance of homeostasis. The theory describing hedonic regulation, so called Incentive Saliance Theory, comprises three major processes: liking (positive attribution to food stimulus), wanting (motivation to gain it) and learning (identification of these stimuli and distinguishing them from those connected with aversive reaction). Neuronal reward circuits are the anatomical and functional substrates of hedonic regulation. They react to gustatory and olfactory (or visual) stimuli associated with food intake. A food item is preferred in case its consumption is connected with a pleasant feeling thus promoting the behavioural reaction. The probability of this reaction after repetitive exposure to such a stimulus is increased (learned preference). On the contrary, learned aversion after repetitive exposure is connected with avoidance of a food item associated with a negative feeling. Main mediators of hedonic regulation are endocannabinoids, opioids and monoamines (dopamine, serotonin). Dopamine in dorsal striatum via D2 receptors generates food motivation as a key means of survival, however in ventral striatum (nucleus accumbens) is responsible for motivation to food bringing pleasure. Serotonin via its receptors 5-HT1A a T-HT2C decreases intake of palatable food. It plays a significant role in the pathogenesis of eating disorders, particulary mental anorexia. There, a food restriction represents a kind of automedication to constitutionally pathologically increased serotonin levels. Detailed understanding of processes regulating food intake is a key to new pharmacological interventions in eating disorders"@en . "13"^^ . . "11120" . "1211-9326" . "Diabetologie, metabolismus, endokrinologie, v\u00FD\u017Eiva" . . "16" . . "2" . "Brunerov\u00E1, Ludmila" . . . . "CZ - \u010Cesk\u00E1 republika" . "Regulace p\u0159\u00EDjmu potravy - II. \u010D\u00E1st"@cs . . "RIV/00216208:11120/13:43907454!RIV14-MSM-11120___" . "Regulace p\u0159\u00EDjmu potravy - II. \u010D\u00E1st"@cs . . "Regulace p\u0159\u00EDjmu potravy - II. \u010D\u00E1st" . "Z(MSM0021620814)" . . . "2"^^ . .