"171004" . "000307435000006" . "11120" . "RIV/00216208:11120/12:43907617" . "4" . . . "Determination of predictors of a favourable outcome in patients treated with thrombolytic therapy for acute stroke, analysis of the SITS (Safe Implementation of Treatments in Stroke) Registry. Background: Identification of predictors of a favourable outcome in stroke patients treated with thrombolysis might help in determining their prognosis and individualizing treatment. The aim of our study was to identify predictors of a favourable outcome in stroke patients treated with systemic thrombolysis. Method: We analyzed data entered in the SITS Registry (Safe Implementation of Treatments in Stroke) in the Czech Republic between February 2003 and February 2010. Univariate and multivariate regressive analyses were used to identify predictors of a favourable outcome as defined by the modified Rankin scale 0-1 at 3 months. Results: Overall in the Czech Republic, 3,053 patients were treated with intravenous thrombolysis. A total of 462 (15%) patients died and 1,308 (43%) achieved a favourable outcome. Symptomatic intracerebral haemorrhages (as per the SITS definition) were observed in 62 (2%) patients. Multivariate analyses identified the following characteristics to be significantly associated with a favourable outcome: age (10-year increments) - OR 0.90, 95% CI (0.83-0.97); systolic blood pressure (10 mmHg increments) - OR 0.92, 95% CI (0.88-0.97); stroke severity at baseline measured by NIHSS score (5-point increments) - OR 0.52, 95% CI (0.47-0.56); glucose (5 mmol/L increments) - OR 0.61, 95% CI (0.51-0.73) and diagnosis of embolic etiology of stroke (163.4 according to the International Classification of Diseases) - OR 0.75, 95% CI (0.62-0.90). Conclusion: In our study, we identified several important prognostic predictors determining a clinical outcome of stroke patients treated with intravenous thrombolysis in the Czech Republic. Knowledge of these predictors allows clinicians to predict patient prognosis and manage risk factors."@en . "CZ - \u010Cesk\u00E1 republika" . "[99F0C04E38B5]" . . "\u0160koda, Ond\u0159ej" . . "RIV/00216208:11120/12:43907617!RIV14-MSM-11120___" . . "6"^^ . . "75" . "Stanoven\u00ED prognostick\u00FDch faktor\u016F trombolytick\u00E9 l\u00E9\u010Dby u pacient\u016F s akutn\u00EDm mozkov\u00FDm infarktem \u2013 anal\u00FDza registru SITS"@cs . . . . "6"^^ . "outcome; predictors; intravenous thrombolysis; ischemic stroke"@en . . "Identification of Prognostic Factors for Thrombolytic Therapy in Patients with Acute Stroke - Analysis of the SITS Registry"@en . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . . . . "Identification of Prognostic Factors for Thrombolytic Therapy in Patients with Acute Stroke - Analysis of the SITS Registry"@en . . "Identifikace faktor\u016F ovliv\u0148uj\u00EDc\u00EDch v\u00FDsledn\u00FD stav pacient\u016F po trombol\u00FDze umo\u017E\u0148uje stanovit progn\u00F3zu v \u010Dasn\u00E9 f\u00E1zi c\u00E9vn\u00ED mozkov\u00E9 p\u0159\u00EDhody a ovlivnit l\u00E9\u010Dbu. C\u00EDlem na\u0161\u00ED pr\u00E1ce proto bylo zji\u0161t\u011Bn\u00ED prognostick\u00FDch ukazatel\u016F p\u0159\u00EDzniv\u00E9ho v\u00FDsledn\u00E9ho klinick\u00E9ho stavu pacient\u016F s mozkov\u00FDm infarktem l\u00E9\u010Den\u00FDch pomoc\u00ED syst\u00E9mov\u00E9 trombol\u00FDzy. Metodologie: Byly zpracovany \u00FAdaje vlo\u017Een\u00E9 do SITS registru (Safe Implementation of Treatments in Stroke) z \u010Cesk\u00E9 republiky v obdob\u00ED 2/2003\u20132/2010 s c\u00EDlem ur\u010Dit pomoc\u00ED uni- a multivariabiln\u00ED regresn\u00ED anal\u00FDzy ukazatele p\u0159\u00EDzniv\u00E9ho v\u00FDsledn\u00E9ho klinick\u00E9ho stavu, definovan\u00E9ho v modifikovan\u00E9 Rankinov\u011B \u0161k\u00E1le 0\u20131 bodem. V\u00FDsledky: V letech 2003 a\u017E 2010 bylo v \u010Cesk\u00E9 republice dle registru SITS l\u00E9\u010Deno syst\u00E9movou trombol\u00FDzou celkem 3 053 pacient\u016F. Celkov\u011B 462 (15 %) pacient\u016F zem\u0159elo a dobr\u00E9ho klinick\u00E9ho stavu bylo dosa\u017Eeno u 1 308 (43 %) pacient\u016F. Symptomatick\u00E9 intracerebr\u00E1ln\u00ED krv\u00E1cen\u00ED podle definice SITS prob\u011Bhlo u 62 (2 %) pacient\u016F. P\u0159i multivariabiln\u00ED anal\u00FDze byly v\u00FDznamn\u011B asociov\u00E1ny s p\u0159\u00EDzniv\u00FDm v\u00FDsledn\u00FDm stavem pacient\u016F n\u00E1sleduj\u00EDc\u00ED faktory: v\u011Bk (zvy\u0161uj\u00EDc\u00ED se po 10 letech) \u2013 OR 0,90; 95% CI (0,83\u20130,97); systolick\u00FD krevn\u00ED tlak (zvy\u0161uj\u00EDc\u00ED se po 10 mmHg) \u2013 OR 0,92; 95% CI (0,88\u20130,97); vstupn\u00ED klinick\u00FD stav pacienta m\u011B\u0159en\u00FD dle NIHSS (zvy\u0161uj\u00EDc\u00ED se po 5 bodech \u0161k\u00E1\u00ADly) \u2013 OR 0,52; 95% CI (0,47\u20130,56); hladina glykemie (zvy\u0161uj\u00EDc\u00ED se o 5 mmol/L) \u2013 OR 0,61, 95% CI (0,51\u20130,73) a diagn\u00F3za embolick\u00E9 mozkov\u00E9 ischemie (I63.4 dle Mezin\u00E1rodn\u00ED klasifikace nemoc\u00ED) \u2013 OR 0,75; 95% CI (0,62\u20130,90). Z\u00E1v\u011Br: V na\u0161\u00ED pr\u00E1ci jsme identifikovali n\u011Bkolik v\u00FDznamn\u00FDch prognostick\u00FDch faktor\u016F ovliv\u0148uj\u00EDc\u00EDch v\u00FDsledn\u00FD klinick\u00FD stav pacient\u016F l\u00E9\u010Den\u00FDch syst\u00E9movou trombol\u00FDzou v \u010CR. Znalost t\u011Bchto prediktor\u016F umo\u017E\u0148uje klinikovi ur\u010Dit progn\u00F3zu pacienta l\u00E9\u010Den\u00E9ho syst\u00E9movou trombol\u00FDzou a ovlivnit l\u00E9\u010Dbu rizikov\u00FDch faktor\u016F." . . "Stanoven\u00ED prognostick\u00FDch faktor\u016F trombolytick\u00E9 l\u00E9\u010Dby u pacient\u016F s akutn\u00EDm mozkov\u00FDm infarktem \u2013 anal\u00FDza registru SITS" . "1"^^ . . "P(ED1.100/02/0123), S, V" . "1210-7859" . "Identifikace faktor\u016F ovliv\u0148uj\u00EDc\u00EDch v\u00FDsledn\u00FD stav pacient\u016F po trombol\u00FDze umo\u017E\u0148uje stanovit progn\u00F3zu v \u010Dasn\u00E9 f\u00E1zi c\u00E9vn\u00ED mozkov\u00E9 p\u0159\u00EDhody a ovlivnit l\u00E9\u010Dbu. C\u00EDlem na\u0161\u00ED pr\u00E1ce proto bylo zji\u0161t\u011Bn\u00ED prognostick\u00FDch ukazatel\u016F p\u0159\u00EDzniv\u00E9ho v\u00FDsledn\u00E9ho klinick\u00E9ho stavu pacient\u016F s mozkov\u00FDm infarktem l\u00E9\u010Den\u00FDch pomoc\u00ED syst\u00E9mov\u00E9 trombol\u00FDzy. Metodologie: Byly zpracovany \u00FAdaje vlo\u017Een\u00E9 do SITS registru (Safe Implementation of Treatments in Stroke) z \u010Cesk\u00E9 republiky v obdob\u00ED 2/2003\u20132/2010 s c\u00EDlem ur\u010Dit pomoc\u00ED uni- a multivariabiln\u00ED regresn\u00ED anal\u00FDzy ukazatele p\u0159\u00EDzniv\u00E9ho v\u00FDsledn\u00E9ho klinick\u00E9ho stavu, definovan\u00E9ho v modifikovan\u00E9 Rankinov\u011B \u0161k\u00E1le 0\u20131 bodem. V\u00FDsledky: V letech 2003 a\u017E 2010 bylo v \u010Cesk\u00E9 republice dle registru SITS l\u00E9\u010Deno syst\u00E9movou trombol\u00FDzou celkem 3 053 pacient\u016F. Celkov\u011B 462 (15 %) pacient\u016F zem\u0159elo a dobr\u00E9ho klinick\u00E9ho stavu bylo dosa\u017Eeno u 1 308 (43 %) pacient\u016F. Symptomatick\u00E9 intracerebr\u00E1ln\u00ED krv\u00E1cen\u00ED podle definice SITS prob\u011Bhlo u 62 (2 %) pacient\u016F. P\u0159i multivariabiln\u00ED anal\u00FDze byly v\u00FDznamn\u011B asociov\u00E1ny s p\u0159\u00EDzniv\u00FDm v\u00FDsledn\u00FDm stavem pacient\u016F n\u00E1sleduj\u00EDc\u00ED faktory: v\u011Bk (zvy\u0161uj\u00EDc\u00ED se po 10 letech) \u2013 OR 0,90; 95% CI (0,83\u20130,97); systolick\u00FD krevn\u00ED tlak (zvy\u0161uj\u00EDc\u00ED se po 10 mmHg) \u2013 OR 0,92; 95% CI (0,88\u20130,97); vstupn\u00ED klinick\u00FD stav pacienta m\u011B\u0159en\u00FD dle NIHSS (zvy\u0161uj\u00EDc\u00ED se po 5 bodech \u0161k\u00E1\u00ADly) \u2013 OR 0,52; 95% CI (0,47\u20130,56); hladina glykemie (zvy\u0161uj\u00EDc\u00ED se o 5 mmol/L) \u2013 OR 0,61, 95% CI (0,51\u20130,73) a diagn\u00F3za embolick\u00E9 mozkov\u00E9 ischemie (I63.4 dle Mezin\u00E1rodn\u00ED klasifikace nemoc\u00ED) \u2013 OR 0,75; 95% CI (0,62\u20130,90). Z\u00E1v\u011Br: V na\u0161\u00ED pr\u00E1ci jsme identifikovali n\u011Bkolik v\u00FDznamn\u00FDch prognostick\u00FDch faktor\u016F ovliv\u0148uj\u00EDc\u00EDch v\u00FDsledn\u00FD klinick\u00FD stav pacient\u016F l\u00E9\u010Den\u00FDch syst\u00E9movou trombol\u00FDzou v \u010CR. Znalost t\u011Bchto prediktor\u016F umo\u017E\u0148uje klinikovi ur\u010Dit progn\u00F3zu pacienta l\u00E9\u010Den\u00E9ho syst\u00E9movou trombol\u00FDzou a ovlivnit l\u00E9\u010Dbu rizikov\u00FDch faktor\u016F."@cs . . "Stanoven\u00ED prognostick\u00FDch faktor\u016F trombolytick\u00E9 l\u00E9\u010Dby u pacient\u016F s akutn\u00EDm mozkov\u00FDm infarktem \u2013 anal\u00FDza registru SITS"@cs . . . "Stanoven\u00ED prognostick\u00FDch faktor\u016F trombolytick\u00E9 l\u00E9\u010Dby u pacient\u016F s akutn\u00EDm mozkov\u00FDm infarktem \u2013 anal\u00FDza registru SITS" .