. "RIV/00216208:11120/12:43906439" . "Cerebrospinal Fluid Triplet in the Diagnosis of Alzheimer-Fischer disease"@en . . . . "Likvorov\u00FD triplet (tau proteiny a beta-amyloid) v diagnostice Alzheimerovy-Fischerovy nemoci"@cs . . . . . . "1210-7859" . . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "Barto\u0161, Ale\u0161" . . . "Likvorov\u00FD triplet (tau proteiny a beta-amyloid) v diagnostice Alzheimerovy-Fischerovy nemoci" . . "[58E871B94699]" . "75" . . . "\u010Cechov\u00E1, Linda" . "\u00DAvod: Klinick\u00E9 podez\u0159en\u00ED na nemoc s demenc\u00ED poprv\u00E9 popsanou Alzheimerem a Fischerem lze podpo\u0159it zm\u011Bnami koncentrac\u00ED t\u0159\u00ED b\u00EDlkovin v mozkom\u00ED\u0161n\u00EDm moku: zv\u00FD\u0161en\u00ED celkov\u00E9ho a fosforylovan\u00E9ho tau proteinu a sn\u00ED\u017Een\u00ED beta-amyloidu (tzv. likvorov\u00FD triplet). C\u00EDlem pr\u00E1ce bylo ur\u010Dit jejich norm\u00E1ln\u00ED koncentrace a porovnat je s hladinami u pacient\u016F s Alzheimerovou-Fischerovou nemoc\u00ED a dal\u0161\u00EDmi demencemi. Soubor a metodika: U 65 neurologick\u00FDch pacient\u016F bez kognitivn\u00EDho deficitu (kontroly) [Mini-Mental State Examination, medi\u00E1n a interkvartilov\u00E9 rozmez\u00ED: 29 (28-29) bod\u016F] a 34 pacient\u016F s A lzheimerovou-Fischerovou nemoc\u00ED podle NINCDS -ADRDA krit\u00E9ri\u00ED [Mini-Mental State Examination 21 (18-23) bod\u016F] jsme v laborato\u0159i AD Centra zm\u011B\u0159ili metodou Enzyme-Linked ImmunoSorbent Assay koncentrace likvorov\u00E9ho tripletu. Hrani\u010Dn\u00ED hodnoty jsme ur\u010Dili podle metody zalo\u017Een\u00E9 na k\u0159ivk\u00E1ch receiver operating characteristic k dosa\u017Een\u00ED maxim\u00E1ln\u00ED senzitivity a sou\u010Dasn\u011B specificity."@cs . "000309087800008" . "\u00DAvod: Klinick\u00E9 podez\u0159en\u00ED na nemoc s demenc\u00ED poprv\u00E9 popsanou Alzheimerem a Fischerem lze podpo\u0159it zm\u011Bnami koncentrac\u00ED t\u0159\u00ED b\u00EDlkovin v mozkom\u00ED\u0161n\u00EDm moku: zv\u00FD\u0161en\u00ED celkov\u00E9ho a fosforylovan\u00E9ho tau proteinu a sn\u00ED\u017Een\u00ED beta-amyloidu (tzv. likvorov\u00FD triplet). C\u00EDlem pr\u00E1ce bylo ur\u010Dit jejich norm\u00E1ln\u00ED koncentrace a porovnat je s hladinami u pacient\u016F s Alzheimerovou-Fischerovou nemoc\u00ED a dal\u0161\u00EDmi demencemi. Soubor a metodika: U 65 neurologick\u00FDch pacient\u016F bez kognitivn\u00EDho deficitu (kontroly) [Mini-Mental State Examination, medi\u00E1n a interkvartilov\u00E9 rozmez\u00ED: 29 (28-29) bod\u016F] a 34 pacient\u016F s A lzheimerovou-Fischerovou nemoc\u00ED podle NINCDS -ADRDA krit\u00E9ri\u00ED [Mini-Mental State Examination 21 (18-23) bod\u016F] jsme v laborato\u0159i AD Centra zm\u011B\u0159ili metodou Enzyme-Linked ImmunoSorbent Assay koncentrace likvorov\u00E9ho tripletu. Hrani\u010Dn\u00ED hodnoty jsme ur\u010Dili podle metody zalo\u017Een\u00E9 na k\u0159ivk\u00E1ch receiver operating characteristic k dosa\u017Een\u00ED maxim\u00E1ln\u00ED senzitivity a sou\u010Dasn\u011B specificity." . "11120" . "Likvorov\u00FD triplet (tau proteiny a beta-amyloid) v diagnostice Alzheimerovy-Fischerovy nemoci"@cs . "CZ - \u010Cesk\u00E1 republika" . "7"^^ . . "5"^^ . "P(NS10369)" . . "http://www.csnn.eu/ceska-slovenska-neurologie-clanek/likvorovy-triplet-tau-proteiny-a-beta-amyloid-v-diagnostice-alzheimerovy-fischerovy-nemoci-38696" . "147073" . "Introduction: Clinical suspicion of a disease with dementia first described by Alzheimer and Fischer can be supported by changes in concentrations of three proteins in the cerebrospinal fluid: an increase in total tau and phosphorylated tau proteins and a decrease in beta-amyloid (so-called cerebrospinal fluid triplet). The aim of this research was to determine normal concentrations and compare them with levels in patients with Alzheimer-Fischer disease and other dementias. Patients and methods: We measured concentrations of cerebrospinal fluid triplet in the laboratory of the AD Center using Enzyme-Linked ImmunoSorbent Assay in 65 neurological patients without cognitive deficit (controls) [Mini-Mental State Examination, median and interquartile range: 29 (28\u201329) points] and 34 patients with Alzheimer-Fischer disease according to NINCDS -ADRDA criteria [Mini-Mental State Examination 21 (18\u201323) points]. Cut-off concentrations were determined using an analysis of receiver operating characteristic curves to achieve maximum sensitivity as well as specificity."@en . "beta amyloid; tau protein; cerebrospinal fluid; diagnosis; dementia; Alzheimer\u2019s disease"@en . . "RIV/00216208:11120/12:43906439!RIV13-MZ0-11120___" . . "Cerebrospinal Fluid Triplet in the Diagnosis of Alzheimer-Fischer disease"@en . "2"^^ . "5" . "Likvorov\u00FD triplet (tau proteiny a beta-amyloid) v diagnostice Alzheimerovy-Fischerovy nemoci" . .