"I, P(NS10369)" . . . "3" . . "[CF2014EA1A69]" . "Tau protein and anti-tau antibodies in patients with multiple sclerosis"@en . . "Tau protein and anti-tau antibodies in patients with multiple sclerosis"@en . . "000305819900006" . . "Tau protein and anti-tau antibodies in patients with multiple sclerosis" . "\u010Cesk\u00E1 a slovensk\u00E1 neurologie a neurochirurgie" . "RIV/00216208:11120/12:43903694!RIV13-MZ0-11120___" . . "Background: Neuronal damage in multiple sclerosis (MS) may be associated with the release of cytoskeletal tau protein. This antigen interacts with dysregulated immune system and this results in anti-tau antibody synthesis. Tau-protein concentrations and anti-tau antibody levels in cerebrospinal fluid (CSF) and in serum may correlate. Methods: Total tau protein and anti- -tau antibodies measured using ELISA methods were studied in 31 patients (14 MS patients and 17 neurological controls). We calculated three ratios: the CSF tau concentration to a) the CSF anti-tau antibody level, b) the serum anti-tau antibody concentration and c) the level of intrathecal anti-tau antibodies. Results: We did not find any significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the MS group or in the controls. There was no difference in the CSF tau concentrations or any of the calculated ratios between MS patients and controls. Conclusions: The release of tau protein into CSF and anti-tau humoral response are independent processes in MS and do not differentiate the MS patients from other neurological patients."@en . . "Tau protein and anti-tau antibodies in patients with multiple sclerosis" . "4"^^ . . "http://www.csnn.eu/ceska-slovenska-neurologie-clanek/tau-protein-a-anti-tau-protilatky-u-pacientu-s-roztrousenou-sklerozou-38120?confirm_rules=1" . . . . "Background: Neuronal damage in multiple sclerosis (MS) may be associated with the release of cytoskeletal tau protein. This antigen interacts with dysregulated immune system and this results in anti-tau antibody synthesis. Tau-protein concentrations and anti-tau antibody levels in cerebrospinal fluid (CSF) and in serum may correlate. Methods: Total tau protein and anti- -tau antibodies measured using ELISA methods were studied in 31 patients (14 MS patients and 17 neurological controls). We calculated three ratios: the CSF tau concentration to a) the CSF anti-tau antibody level, b) the serum anti-tau antibody concentration and c) the level of intrathecal anti-tau antibodies. Results: We did not find any significant correlation between the tau protein concentrations and anti-tau antibody levels (serum, CSF or intrathecal) in the MS group or in the controls. There was no difference in the CSF tau concentrations or any of the calculated ratios between MS patients and controls. Conclusions: The release of tau protein into CSF and anti-tau humoral response are independent processes in MS and do not differentiate the MS patients from other neurological patients." . "11120" . "Fialov\u00E1, Lenka" . "1"^^ . . . "CZ - \u010Cesk\u00E1 republika" . "multiple sclerosis; cerebro\u00ADspinal fluid; autoantibodies; tau protein"@en . . "75" . "4"^^ . "1210-7859" . "Barto\u0161, Ale\u0161" . . "RIV/00216208:11120/12:43903694" . . "173278" . .