"The aim of our study was to examine whether the changes of current density detected by standardized low resolution brain electromagnetic tomography (sLORETA) is different between responders and non-responders to prefrontal rTMS. A total of 25 inpatients with depressive disorder (DSM-IV criteria), who previously did not respond to at least one antidepressant treatment underwent 4 weeks of rTMS treatment (1 Hz, 100 % of motor threshold, 600 pulses/session, 20 session) applied over the right dorsolateral prefrontal cortex. The effect of rTMS on brain electrical activity (detected by the use of sLORETA) was measured before treatment and 3 days after rTMS treatment separately in responders (reduction of MADRS >= 50 %) and non-responders. The current density in alpha 1 band increased in prefrontal and limbic cortex (Brodman areas 6, 8, 9, 32) bilaterally (p < 0.05, corrected) in a group of nine responders. No significant changes were detected in non-responders. Our findings implicate that the antidepr"@en . . "Zm\u011Bny proudov\u00E9 hustoty (sLORETA) po aplikaci pravostrann\u00E9 prefront\u00E1ln\u00ED 1Hz repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E9 stimulace v l\u00E9\u010Db\u011B depresivn\u00ED poruchy" . "C\u00EDlem studie bylo zjistit, zda se zm\u011Bny proudov\u00E9 hustoty detekovan\u00E9 standardizovanou mozkovou elektromagnetickou tomografi\u00ED s n\u00EDzk\u00FDm rozli\u0161en\u00EDm (sLORETA) m\u011Bn\u00ED v z\u00E1vislosti na odpov\u011Bdi na l\u00E9\u010Dbu prefront\u00E1ln\u00ED rTMS. Do studie bylo za\u0159azeno 25 hospitalizovan\u00FDch pacient\u00F9 spl\u0148uj\u00EDc\u00EDch krit\u00E9ria depresivn\u00ED poruchy (dle DSM-IV), kte\u0159\u00ED neodpov\u011Bd\u011Bli minim\u00E1ln\u011B na jednu antidepresivn\u00ED l\u00E9\u010Dbu, podrobili se 4t\u00FDdenn\u00ED l\u00E9\u010Db\u011B rTMS (1 Hz, 100 % motorick\u00E9ho prahu, 600 pulz\u00F9 na sezen\u00ED, 20 sezen\u00ED) aplikovan\u00E9 nad pravou dorzolater\u00E1ln\u00ED prefron\u00E1ln\u00ED k\u016Fru. \u00DA\u010Dinek rTMS na zm\u011Bny proudov\u00E9 hustoty p\u0159ed l\u00E9\u010Dbou a po 3 dnech od ukon\u010Den\u00ED l\u00E9\u010Dby rTMS byl hodnocen pomoc\u00ED sLORETA separ\u00E1tn\u011B pro respond\u00E9ry (pokles >= 50 % MADRS) a non-respond\u00E9ry. U dev\u00EDti pacient\u00F9, kte\u0159\u00ED odpov\u011Bd\u011Bli na l\u00E9\u010Dbu bylo zji\u0161t\u011Bno zv\u00FD\u0161en\u00ED proudov\u00E9 hustoty v p\u00E1smu alfa 1 ve front\u00E1ln\u00ED a limbick\u00E9 oblasti (Brodmanova area 6, 8, 9, 32) oboustrann\u011B (p < 0,05, po korekci na mnoho\u010Detn\u00E1 srovn\u00E1v\u00E1n\u00ED). Ve skupin\u011B non-respond\u00E9r\u00F9 nebyly po l\u00E9\u010Db\u011B detekov\u00E1ny \u017E\u00E1d" . . . "[2FE302AE33A1]" . "http://www.tigis.cz/images/stories/psychiatrie/2011/s2/13_kopecek_cns_2-11.pdf" . . . "\u0160\u00F3\u0161, Peter" . "243387" . "Current density changes (sLORETA) after right prefrontal 1Hz repetitive transcranial magnetic stimulation in patients with depressive disorder"@en . "Zm\u011Bny proudov\u00E9 hustoty (sLORETA) po aplikaci pravostrann\u00E9 prefront\u00E1ln\u00ED 1Hz repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E9 stimulace v l\u00E9\u010Db\u011B depresivn\u00ED poruchy"@cs . "Koh\u00FAtov\u00E1, Barbora" . . "5"^^ . . . "Stopkov\u00E1, Pavla" . "7"^^ . "Zm\u011Bny proudov\u00E9 hustoty (sLORETA) po aplikaci pravostrann\u00E9 prefront\u00E1ln\u00ED 1Hz repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E9 stimulace v l\u00E9\u010Db\u011B depresivn\u00ED poruchy" . "Kope\u010Dek, Miloslav" . "7"^^ . . "Bare\u0161, Martin" . "CZ - \u010Cesk\u00E1 republika" . . . "repetitive transcranial magnetic stimulation (rTMS); low frequency stimulation; depressive disorder; EEG; electrophysiology; LORETA; current density; neuroimaging"@en . "Current density changes (sLORETA) after right prefrontal 1Hz repetitive transcranial magnetic stimulation in patients with depressive disorder"@en . . . "RIV/00216208:11120/11:00003488" . "Zm\u011Bny proudov\u00E9 hustoty (sLORETA) po aplikaci pravostrann\u00E9 prefront\u00E1ln\u00ED 1Hz repetitivn\u00ED transkrani\u00E1ln\u00ED magnetick\u00E9 stimulace v l\u00E9\u010Db\u011B depresivn\u00ED poruchy"@cs . . . . "11120" . "RIV/00216208:11120/11:00003488!RIV12-MSM-11120___" . . . . . "Psychiatrie" . . "Nov\u00E1k, Tom\u00E1\u0161" . . "1211-7579" . "15" . "Suppl. 2" . . . "P(1M0517)" . . "C\u00EDlem studie bylo zjistit, zda se zm\u011Bny proudov\u00E9 hustoty detekovan\u00E9 standardizovanou mozkovou elektromagnetickou tomografi\u00ED s n\u00EDzk\u00FDm rozli\u0161en\u00EDm (sLORETA) m\u011Bn\u00ED v z\u00E1vislosti na odpov\u011Bdi na l\u00E9\u010Dbu prefront\u00E1ln\u00ED rTMS. Do studie bylo za\u0159azeno 25 hospitalizovan\u00FDch pacient\u00F9 spl\u0148uj\u00EDc\u00EDch krit\u00E9ria depresivn\u00ED poruchy (dle DSM-IV), kte\u0159\u00ED neodpov\u011Bd\u011Bli minim\u00E1ln\u011B na jednu antidepresivn\u00ED l\u00E9\u010Dbu, podrobili se 4t\u00FDdenn\u00ED l\u00E9\u010Db\u011B rTMS (1 Hz, 100 % motorick\u00E9ho prahu, 600 pulz\u00F9 na sezen\u00ED, 20 sezen\u00ED) aplikovan\u00E9 nad pravou dorzolater\u00E1ln\u00ED prefron\u00E1ln\u00ED k\u016Fru. \u00DA\u010Dinek rTMS na zm\u011Bny proudov\u00E9 hustoty p\u0159ed l\u00E9\u010Dbou a po 3 dnech od ukon\u010Den\u00ED l\u00E9\u010Dby rTMS byl hodnocen pomoc\u00ED sLORETA separ\u00E1tn\u011B pro respond\u00E9ry (pokles >= 50 % MADRS) a non-respond\u00E9ry. U dev\u00EDti pacient\u00F9, kte\u0159\u00ED odpov\u011Bd\u011Bli na l\u00E9\u010Dbu bylo zji\u0161t\u011Bno zv\u00FD\u0161en\u00ED proudov\u00E9 hustoty v p\u00E1smu alfa 1 ve front\u00E1ln\u00ED a limbick\u00E9 oblasti (Brodmanova area 6, 8, 9, 32) oboustrann\u011B (p < 0,05, po korekci na mnoho\u010Detn\u00E1 srovn\u00E1v\u00E1n\u00ED). Ve skupin\u011B non-respond\u00E9r\u00F9 nebyly po l\u00E9\u010Db\u011B detekov\u00E1ny \u017E\u00E1d"@cs . . . "Brunovsk\u00FD, Martin" .