"17" . "Exogenn\u00ED Gushing\u016Fv syndrom jako z\u00E1va\u017En\u00FD ne\u017E\u00E1douc\u00ED \u00FA\u010Dinek l\u00E9\u010Dby ritonavirem a inhala\u010Dn\u00EDm flutikazonem" . "1"^^ . . "V" . . "Exogenn\u00ED Gushing\u016Fv syndrom jako z\u00E1va\u017En\u00FD ne\u017E\u00E1douc\u00ED \u00FA\u010Dinek l\u00E9\u010Dby ritonavirem a inhala\u010Dn\u00EDm flutikazonem"@cs . . . . "Inhalation of fluticasone is usually devoid of systemic side-effects. The authors describe a case of a yound HIV positive woman treated concomitantly with fluticasone and inhibitors of HIV protease ritonavir and lopinavir in which developed a serious endocrine side-effecet - an iatrogenic Cushing\u015B syndrome. Plasma concentration of cortisol less than 5,5 nmol/l was very low (norm 250-650 nmol/l) and plasmatic ACTH was even not detectable. The administration of fluticasone and both inhibitors of HIV protease was stopped and substitution therapy with decreasing dose of hydrocortisone was initiated. Twenty weeks later resolved both clinical and laboratory symptoms of Cushing\u015B syndrome, and the substitution therapy with hydrocortisone was teminated. Two years later became the patient pregnant and gave birth to a healthy child."@en . "CZ - \u010Cesk\u00E1 republika" . "1211-264X" . "4"^^ . . "Inhala\u010Dn\u00ED pod\u00E1v\u00E1n\u00ED flutikazonu obvykle nen\u00ED spojeno se syst\u00E9mov\u00FDmi ne\u017E\u00E1douc\u00EDmi \u00FA\u010Dinky. Auto\u0159i popisuj\u00ED p\u0159\u00EDpad mlad\u00E9 HIV pozitivn\u00ED \u017Eeny, u kter\u00E9 se v d\u016Fsledku sou\u010Dasn\u00E9ho pod\u00E1v\u00E1vn\u00ED flutikazonu a ihibitor\u016F HIV prote\u00E1zy ritonaviru a lopinaviru vyvinul z\u00E1va\u017En\u00FD ne\u017E\u00E1douc\u00ED endokrinologick\u00FD \u00FA\u010Dinek - iatrogenn\u00ED Cushing\u016Fv syndrom. Hodnota plazmatick\u00E9ho kortizolu m\u00E9n\u011B ne\u017E 5,5 nmol/l byla velmi n\u00EDzk\u00E1 (norma 250-650 nmol/l), hladina ACTH nebyla m\u011B\u0159iteln\u00E1 v\u016Fbec. Po vysazen\u00ED flutikazonu i obou inhibitor\u016F HIV prote\u00E1zy a zah\u00E1jen\u00ED substitu\u010Dn\u00ED l\u00E9\u010Dby hydrokortizonem v sestupn\u00E9 d\u00E1vce do\u0161lo b\u011Bhem 20 t\u00FDdn\u016F k normalizaci klinick\u00E9ho n\u00E1lezu i laborazorn\u00EDch hodnot. Po dvou letech pacientka ot\u011Bhotn\u011Bla a porodila zdrav\u00E9 d\u00EDt\u011B."@cs . "Exogenn\u00ED Gushing\u016Fv syndrom jako z\u00E1va\u017En\u00FD ne\u017E\u00E1douc\u00ED \u00FA\u010Dinek l\u00E9\u010Dby ritonavirem a inhala\u010Dn\u00EDm flutikazonem"@cs . "3"^^ . "11120" . "198658" . "Inhala\u010Dn\u00ED pod\u00E1v\u00E1n\u00ED flutikazonu obvykle nen\u00ED spojeno se syst\u00E9mov\u00FDmi ne\u017E\u00E1douc\u00EDmi \u00FA\u010Dinky. Auto\u0159i popisuj\u00ED p\u0159\u00EDpad mlad\u00E9 HIV pozitivn\u00ED \u017Eeny, u kter\u00E9 se v d\u016Fsledku sou\u010Dasn\u00E9ho pod\u00E1v\u00E1vn\u00ED flutikazonu a ihibitor\u016F HIV prote\u00E1zy ritonaviru a lopinaviru vyvinul z\u00E1va\u017En\u00FD ne\u017E\u00E1douc\u00ED endokrinologick\u00FD \u00FA\u010Dinek - iatrogenn\u00ED Cushing\u016Fv syndrom. Hodnota plazmatick\u00E9ho kortizolu m\u00E9n\u011B ne\u017E 5,5 nmol/l byla velmi n\u00EDzk\u00E1 (norma 250-650 nmol/l), hladina ACTH nebyla m\u011B\u0159iteln\u00E1 v\u016Fbec. Po vysazen\u00ED flutikazonu i obou inhibitor\u016F HIV prote\u00E1zy a zah\u00E1jen\u00ED substitu\u010Dn\u00ED l\u00E9\u010Dby hydrokortizonem v sestupn\u00E9 d\u00E1vce do\u0161lo b\u011Bhem 20 t\u00FDdn\u016F k normalizaci klinick\u00E9ho n\u00E1lezu i laborazorn\u00EDch hodnot. Po dvou letech pacientka ot\u011Bhotn\u011Bla a porodila zdrav\u00E9 d\u00EDt\u011B." . . . . "Exogenous Cushing\u015B syndrome as a serious side-effect of therapy with ritonavir an inhaled fluticasone"@en . . . "Exogenn\u00ED Gushing\u016Fv syndrom jako z\u00E1va\u017En\u00FD ne\u017E\u00E1douc\u00ED \u00FA\u010Dinek l\u00E9\u010Dby ritonavirem a inhala\u010Dn\u00EDm flutikazonem" . "RIV/00216208:11120/11:00003427!RIV12-MSM-11120___" . . "3" . . "Klinick\u00E1 mikrobiologie a infek\u010Dn\u00ED l\u00E9ka\u0159stv\u00ED" . "[4E3BC1C898FC]" . . "HIV; Cushing\u00B4s syndrome; fluticasone; protease inhibitors; ritonavir; lopinavir; cytochrome P 450 3A4"@en . "Machala, Ladislav" . . "RIV/00216208:11120/11:00003427" . . . "Exogenous Cushing\u015B syndrome as a serious side-effect of therapy with ritonavir an inhaled fluticasone"@en . . .