"5"^^ . "The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis"@en . "31" . "Jur\u010Dovi\u010Dov\u00E1, Jana" . . "000288508500011" . "Rheumatology International" . "The purpose of this study was to evaluate the effect of beta-(1,3/1,6)-d-glucan isolated from Pleurotus ostreatus (beta-glucan-PO) on prophylactic treatment of adjuvant arthritis (AA) with methotrexate (MTX) in rats. Groups of rats with AA were treated with methotrexate (1 mg/kg/week), beta-glucan-PO (1 mg/kg every second day) or their combination for the period of 28 days from adjuvant application. Body mass, hind paw swelling, arthrogram scores and a level of serum albumin were measured as markers of inflammation and arthritis. Treatment with low dose of MTX significantly inhibited the markers of both inflammation and arthritis. MTX and its combination with beta-glucan-PO significantly increased body mass of arthritic rats. beta-glucan-PO administered alone significantly decreased both the hind paw swelling and arthritic score. In combination with MTX, beta-glucan-PO markedly potentiated the beneficial effects of MTX, which resulted in a more significant reduction of hind paw swelling and arthritic"@en . . . . "0172-8172" . "beta-Glucan; Methotrexate; Adjuvant arthritis"@en . "The purpose of this study was to evaluate the effect of beta-(1,3/1,6)-d-glucan isolated from Pleurotus ostreatus (beta-glucan-PO) on prophylactic treatment of adjuvant arthritis (AA) with methotrexate (MTX) in rats. Groups of rats with AA were treated with methotrexate (1 mg/kg/week), beta-glucan-PO (1 mg/kg every second day) or their combination for the period of 28 days from adjuvant application. Body mass, hind paw swelling, arthrogram scores and a level of serum albumin were measured as markers of inflammation and arthritis. Treatment with low dose of MTX significantly inhibited the markers of both inflammation and arthritis. MTX and its combination with beta-glucan-PO significantly increased body mass of arthritic rats. beta-glucan-PO administered alone significantly decreased both the hind paw swelling and arthritic score. In combination with MTX, beta-glucan-PO markedly potentiated the beneficial effects of MTX, which resulted in a more significant reduction of hind paw swelling and arthritic" . "The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis" . . . . "5"^^ . "RIV/00216208:11120/11:00003404!RIV12-MSM-11120___" . . "The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis" . "11120" . . "N" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "10.1007/s00296-009-1258-z" . "[D5B545C58DCA]" . "RIV/00216208:11120/11:00003404" . "http://dx.doi.org/10.1007/s00296-009-1258-z" . "The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis"@en . . . . "1"^^ . . . "196604" . "4" . . "Rovensk\u00FD, Jozef" .