"[D4D096FC1547]" . . "RIV/00216208:11120/11:00002977!RIV12-MSM-11120___" . "1"^^ . "Rychl\u00EDk, Ivan" . "The prevalence of diabetes, predominantly of type 2, and the incidence of diabetic nephropathy have dramatically increased worldwide. Diabetic patients constitute the largest proportion of patients with end-stage renal disease (ESRD) requiring dialysis or transplantation; in developed countries, this accounts for up to 50% of ESRD patients, but this proportion has stabilized and possibly somewhat decreased in recent years. Chronic kidney disease in diabetic patients is more heterogeneous than previously thought. The largest proportion suffers from proteinuric diabetic nephropathy with Kimmelstiel-Wilson lesions as the underlying pathology, but reduced glomerular filtration rate in the absence of albuminuria/proteinuria is recognized in an increasing proportion of type 2 diabetic patients. Of particular interest is the recent recognition of vascular lesions in the brain and retina as predictors of nonproteinuric nephropathy with reduced GFR; although currently unproven, such lesions may also be of pote" . "Basel" . "3"^^ . "Contributions to Nephrology, Vol. 170" . . "190614" . "276"^^ . . "Karger" . "diabetes nephropathy; clinical manifestation"@en . . . . "9"^^ . "Clinical Manifestation and Natural History of Diabetic Nephropathy" . "11120" . . . "http://content.karger.com/ProdukteDB/produkte.asp?Aktion=showproducts&searchWhat=books&searchParm=toc&ProduktNr=254934" . . "Diabetes and the Kidney" . "The prevalence of diabetes, predominantly of type 2, and the incidence of diabetic nephropathy have dramatically increased worldwide. Diabetic patients constitute the largest proportion of patients with end-stage renal disease (ESRD) requiring dialysis or transplantation; in developed countries, this accounts for up to 50% of ESRD patients, but this proportion has stabilized and possibly somewhat decreased in recent years. Chronic kidney disease in diabetic patients is more heterogeneous than previously thought. The largest proportion suffers from proteinuric diabetic nephropathy with Kimmelstiel-Wilson lesions as the underlying pathology, but reduced glomerular filtration rate in the absence of albuminuria/proteinuria is recognized in an increasing proportion of type 2 diabetic patients. Of particular interest is the recent recognition of vascular lesions in the brain and retina as predictors of nonproteinuric nephropathy with reduced GFR; although currently unproven, such lesions may also be of pote"@en . "Clinical Manifestation and Natural History of Diabetic Nephropathy"@en . . "978-3-8055-9742-5" . "Clinical Manifestation and Natural History of Diabetic Nephropathy"@en . . "N" . . . "Clinical Manifestation and Natural History of Diabetic Nephropathy" . "RIV/00216208:11120/11:00002977" . . "Ritz, Eberhard" .