. "RIV/00216208:11120/10:00002443!RIV11-MZ0-11120___" . . . . . "Dole\u017Eal, Tom\u00E1\u0161" . "0004-4172" . "Sl\u00EDva, Ji\u0159\u00ED" . . . "Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats"@en . . "Beta-cyclodextrin; CAS 7585-39-9; CAS 71125-38-7; Meloxicam, analgesic activity; serum levels"@en . . . "Kr\u0161iak, Miloslav" . "Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats" . "RIV/00216208:11120/10:00002443" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . . . "Janovsk\u00FD, Martin" . . "000279453700006" . "Arzneimittel-Forschung-Drug Research" . "The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam orally than those of unmodified meloxicam (both dosed at 10 mg/kg). The present results suggest that association with beta-cyclodextrin increases the analgesic activity of meloxicam. This may be due to an increased systemic bioavailability of meloxicam after oral administration of its complex with b" . "5"^^ . . "P(NR9072), S, Z(MSM0021620816)" . . "[007A3C8DEA20]" . "5"^^ . "11120" . . "The aim of the present study was to evaluate and compare the analgesic activity and serum levels of meloxicam (CAS 71125-38-7) after administration of meloxicam associated with beta-cyclodextrin (BCD, CAS 7585-39-9) and unmodified meloxicam. The analgesic activity was measured using the plantar test (rats) and the writhing test (mice). In the plantar test, BCD-meloxicam (3 mg/kg and 10 mg/kg orally) showed higher analgesic activity than corresponding doses of meloxicam alone; in the writhing test BCD-meloxicam (7 mg/kg and 15 mg/kg orally) showed stronger analgesic activity than unmodified meloxicam. Serum levels of meloxicam were significantly higher, at 0.5 h and 1 h after administration of BCD-meloxicam orally than those of unmodified meloxicam (both dosed at 10 mg/kg). The present results suggest that association with beta-cyclodextrin increases the analgesic activity of meloxicam. This may be due to an increased systemic bioavailability of meloxicam after oral administration of its complex with b"@en . "4"^^ . "263889" . . "60" . . . "Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats" . . "Proch\u00E1zkov\u00E1, Michaela" . . . "6" . . "Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats"@en . . .