"250252" . "5"^^ . . "Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle"@en . . . "000282395800005" . "Even though it is obvious that glutamate plays an important role in the effect of psychostimulants on seizures, the role of non-NMDA receptors remains uncertain. The aim of the present study was to determine whether acute methamphetamine (MA) administration changes sensitivity to seizures induced with kainic acid in prenatally MA-exposed adult rats. Adult male and female rats (prenatally MA exposed, prenatally saline exposed, and controls) were divided into groups that received a challenge dose (1 mg/kg) of MA and groups that did not receive the MA challenge (saline injected). Systemic administration of 15 mg/kg kainic acid was used as a seizure model. Our results demonstrated that a single injection of MA (1 mg/kg) affects kainic acid-induced seizures differently depending on prenatal exposure, sex, and female estrous cycle. Even though daily injections of MA (5 mg/kg) in maternal rats did not have a long-term effect on susceptibility to seizures induced with kainic acid in adult progeny, sensitivity" . "\u0160lamberov\u00E1, Romana" . . "1525-5050" . . "Epilepsy & Behavior" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . . . . "Even though it is obvious that glutamate plays an important role in the effect of psychostimulants on seizures, the role of non-NMDA receptors remains uncertain. The aim of the present study was to determine whether acute methamphetamine (MA) administration changes sensitivity to seizures induced with kainic acid in prenatally MA-exposed adult rats. Adult male and female rats (prenatally MA exposed, prenatally saline exposed, and controls) were divided into groups that received a challenge dose (1 mg/kg) of MA and groups that did not receive the MA challenge (saline injected). Systemic administration of 15 mg/kg kainic acid was used as a seizure model. Our results demonstrated that a single injection of MA (1 mg/kg) affects kainic acid-induced seizures differently depending on prenatal exposure, sex, and female estrous cycle. Even though daily injections of MA (5 mg/kg) in maternal rats did not have a long-term effect on susceptibility to seizures induced with kainic acid in adult progeny, sensitivity"@en . "Bern\u00E1\u0161kov\u00E1, Kl\u00E1ra" . "Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle" . "Rokyta, Richard" . . "Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle" . "RIV/00216208:11120/10:00002412" . "11120" . "[054D8BC0E58C]" . . . . "Challenge dose of methamphetamine affects kainic acid-induced seizures differently depending on prenatal methamphetamine exposure, sex, and estrous cycle"@en . . "Mat\u011Bjovsk\u00E1, Iveta" . "P(1M0517), P(GAP303/10/0580), Z(MSM0021620816)" . . . . . . "19" . . "Schutov\u00E1, Barbora" . "RIV/00216208:11120/10:00002412!RIV11-GA0-11120___" . . "1" . . "5"^^ . "Estrous cycle; Kainic acid; Methamphetamine; Seizures; Sex difference"@en . . "6"^^ .