. "RIV/00216208:11120/09:00002350!RIV11-MSM-11120___" . "Syst\u00E9mov\u00E1 enzymoterapie po operac\u00EDch v\u00FDh\u0159ezu bedern\u00ED meziobratlov\u00E9 plot\u00E9nky" . "5"^^ . . "Steindler, Ji\u0159\u00ED" . "Klinick\u00E1 farmakologie a farmacie" . . . . "The aim of this open pilot observation was to prove the influence of the long-term oral systemic enzyme therapy (SE) on subjectively perceived pain, disabilities caused by back pain and development of late postoperative complications after lumbar disc herniation surgery. Patients after lumbar disc herniation surgery were randomly divided into two groups. All patients were administered by analgesics and underwent physiotherapy after surgery. The SE group was administered by combined enzyme preparation Phlogenzym (bromelaina 90 mg, trypsinum 48 mg rutosid 100 mg), besides the usual post-operative treatment. The control group KO underwent obligatory treatment only. Preoperative and postoperative status was evaluated according to Visual Analog Scale (VAS), Roland-Morris questionnaire (RMQ) and Oswestry Disability Index (ODI). Subjective evaluation of improvement, development of failed back surgery syndrome (FBSS) and ability to work after surgery were other objectives of the follow-up. Statistical evalua"@en . "V" . . "Syst\u00E9mov\u00E1 enzymoterapie po operac\u00EDch v\u00FDh\u0159ezu bedern\u00ED meziobratlov\u00E9 plot\u00E9nky" . . "345268" . "Peka\u0159, Lubom\u00EDr" . "2"^^ . . "Systemic oral enzyme therapy after lumbar disc herniation surgery"@en . . . "4" . "1"^^ . "CZ - \u010Cesk\u00E1 republika" . . "C\u00EDlem otev\u0159en\u00E9ho pilotn\u00EDho projektu bylo ov\u011B\u0159it, zda dlouhodob\u00E9 pod\u00E1v\u00E1n\u00ED p\u0159\u00EDpravku pro syst\u00E9movou enzymoterapii (SE) po operac\u00EDch prost\u00E9ho v\u00FDh\u0159ezu bedern\u00ED meziobratlov\u00E9 plot\u00E9nky m\u016F\u017Ee ovlivnit subjektivn\u011B vn\u00EDmanou bolest, vznikl\u00E1 poopera\u010Dn\u00ED omezen\u00ED a v\u00FDvoj pozdn\u00EDch poopera\u010Dn\u00EDch komplikac\u00ED. Pacienti operovan\u00ED pro prost\u00FD v\u00FDh\u0159ez bedern\u00ED meziobratlov\u00E9 plot\u00E9nky byli n\u00E1hodn\u011B rozd\u011Bleni do dvou skupin. V\u0161ichni v poopera\u010Dn\u00EDm obdob\u00ED dost\u00E1vali obvykl\u00E1 analgetika (NSAID a opioidy) a absolvovali rehabilitaci. Skupina SE nav\u00EDc u\u017E\u00EDvala enzymov\u00FD p\u0159\u00EDpravek Phlogenzym (bromelain 90 mg, trypsin 48 mg, rutin 100 mg). Kontroln\u00ED skupina KO m\u011Bla pouze obvyklou l\u00E9\u010Dbu. Pacienti byli zv\u00E1ni k ambulantn\u00EDm kontrol\u00E1m za 2, 3, 6 a 12 m\u011Bs\u00EDc\u016F po operaci. P\u0159edopera\u010Dn\u00ED a poopera\u010Dn\u00ED stav byl hodnocen podle vizu\u00E1ln\u00ED analogov\u00E9 \u0161k\u00E1ly bolesti (VAS), Roland-Morrisova dotazn\u00EDku (RMQ) a Oswestry indexu neschopnosti (ODI). Bylo provedeno subjektivn\u00ED zhodnocen\u00ED poopera\u010Dn\u00ED zm\u011Bny stavu pacientem, sledoval se v\u00FDskyt syndromu selh\u00E1n\u00ED operace p\u00E1te\u0159e" . "23" . . "C\u00EDlem otev\u0159en\u00E9ho pilotn\u00EDho projektu bylo ov\u011B\u0159it, zda dlouhodob\u00E9 pod\u00E1v\u00E1n\u00ED p\u0159\u00EDpravku pro syst\u00E9movou enzymoterapii (SE) po operac\u00EDch prost\u00E9ho v\u00FDh\u0159ezu bedern\u00ED meziobratlov\u00E9 plot\u00E9nky m\u016F\u017Ee ovlivnit subjektivn\u011B vn\u00EDmanou bolest, vznikl\u00E1 poopera\u010Dn\u00ED omezen\u00ED a v\u00FDvoj pozdn\u00EDch poopera\u010Dn\u00EDch komplikac\u00ED. Pacienti operovan\u00ED pro prost\u00FD v\u00FDh\u0159ez bedern\u00ED meziobratlov\u00E9 plot\u00E9nky byli n\u00E1hodn\u011B rozd\u011Bleni do dvou skupin. V\u0161ichni v poopera\u010Dn\u00EDm obdob\u00ED dost\u00E1vali obvykl\u00E1 analgetika (NSAID a opioidy) a absolvovali rehabilitaci. Skupina SE nav\u00EDc u\u017E\u00EDvala enzymov\u00FD p\u0159\u00EDpravek Phlogenzym (bromelain 90 mg, trypsin 48 mg, rutin 100 mg). Kontroln\u00ED skupina KO m\u011Bla pouze obvyklou l\u00E9\u010Dbu. Pacienti byli zv\u00E1ni k ambulantn\u00EDm kontrol\u00E1m za 2, 3, 6 a 12 m\u011Bs\u00EDc\u016F po operaci. P\u0159edopera\u010Dn\u00ED a poopera\u010Dn\u00ED stav byl hodnocen podle vizu\u00E1ln\u00ED analogov\u00E9 \u0161k\u00E1ly bolesti (VAS), Roland-Morrisova dotazn\u00EDku (RMQ) a Oswestry indexu neschopnosti (ODI). Bylo provedeno subjektivn\u00ED zhodnocen\u00ED poopera\u010Dn\u00ED zm\u011Bny stavu pacientem, sledoval se v\u00FDskyt syndromu selh\u00E1n\u00ED operace p\u00E1te\u0159e"@cs . "RIV/00216208:11120/09:00002350" . "Syst\u00E9mov\u00E1 enzymoterapie po operac\u00EDch v\u00FDh\u0159ezu bedern\u00ED meziobratlov\u00E9 plot\u00E9nky"@cs . "Syst\u00E9mov\u00E1 enzymoterapie po operac\u00EDch v\u00FDh\u0159ezu bedern\u00ED meziobratlov\u00E9 plot\u00E9nky"@cs . "lumbar disc disease; postoperative treatment; failed back surgery syndrome; systemic oral enzyme therapy"@en . "[860B9C72495D]" . "Systemic oral enzyme therapy after lumbar disc herniation surgery"@en . . . "11120" . . "1212-7973" .