"neuroendocrine tumours; alimentary tract; histological classification; imunohistological markers; biological behaviour"@en . . . . "Histological classification of the neuroendocrine tumours (carcinoids) of the alimentary tract, as well as the opinion on biological behaviour of these tumours, changed rapidly within the last decade. Advances in knowledge of cellular biology of the diffuse endocrine system and in clinical diagnostics and treatment of tumours lead to the creation of a new histological classification of neuroendocrine tumours. This classification, apart from essential histological picture and immunohistological characterisation of the markers of neuroendocrine differentiation, also includes definition of biological properties of tumours based on their site of origin, mitotic and proliferative activity of the tumour cells and clinicopathological correlation, including the size of the tumour and its progression. Exact classification of an individual tumour into a corresponding category is an essential condition to select adequate following diagnostic procedures and optimal therapeutic strategy."@en . . . "RIV/00216208:11120/09:00001794!RIV10-MSM-11120___" . "1210-7875" . "Histologick\u00E1 klasifikace neuroendokrinn\u00EDch n\u00E1dor\u016F (karcinoid\u016F) tr\u00E1vic\u00EDho \u00FAstroj\u00ED a s n\u00ED souvisej\u00EDc\u00ED n\u00E1zory na biologick\u00E9 chov\u00E1n\u00ED t\u011Bchto n\u00E1dor\u016F prod\u011Blaly v uplynul\u00FDch letech podstatn\u00E9 zm\u011Bny. Pokroky v pozn\u00E1n\u00ED biologie bun\u011Bk dif\u00FAzn\u00EDho endokrinn\u00EDho syst\u00E9mu a v klinick\u00E9 diagnostice a terapii n\u00E1dor\u016F k t\u011Bmto bu\u0148k\u00E1m histogeneticky bl\u00EDzk\u00FDm vedly k vytvo\u0159en\u00ED nov\u00E9 klasifikace zalo\u017Een\u00E9 na komplexn\u00EDm posouzen\u00ED n\u00E1doru, zahrnuj\u00EDc\u00EDm krom\u011B z\u00E1kladn\u00EDho mikroskopick\u00E9ho obrazu, imunohistologick\u00E9 detekce znak\u016F neuroendokrinn\u00ED diferenciace i ur\u010Den\u00ED jeho biologick\u00FDch vlastnost\u00ED podle lokalizace n\u00E1doru, mitotick\u00E9 a prolifera\u010Dn\u00ED aktivity n\u00E1dorov\u00FDch bun\u011Bk a klinicko-patologick\u00E9 korelace, vych\u00E1zej\u00EDc\u00ED z velikosti n\u00E1doru a rozsahu jeho r\u016Fstu. P\u0159esn\u00E9 za\u0159azen\u00ED n\u00E1doru do p\u0159\u00EDslu\u0161n\u00E9 kategorie je nezbytnou podm\u00EDnkou pro spr\u00E1vnou volbu dal\u0161\u00EDch diagnostick\u00FDch krok\u016F a pro ur\u010Den\u00ED optim\u00E1ln\u00ED terapeutick\u00E9 strategie." . . . "RIV/00216208:11120/09:00001794" . . "7"^^ . . "11120" . "Neuroendocrine Tumours of the Alimentary Tract - History and at Present"@en . "[63461980DFEE]" . "Neuroendokrinn\u00ED n\u00E1dory tr\u00E1vic\u00EDho \u00FAstroj\u00ED - historie a sou\u010Dasnost" . . . "\u010Cesko-slovensk\u00E1 patologie a soudn\u00ED l\u00E9ka\u0159stv\u00ED" . "1"^^ . "Neuroendokrinn\u00ED n\u00E1dory tr\u00E1vic\u00EDho \u00FAstroj\u00ED - historie a sou\u010Dasnost" . . "329235" . "1"^^ . "Mandys, V\u00E1clav" . "45" . "CZ - \u010Cesk\u00E1 republika" . "Z(MSM0021620808)" . . . "Neuroendocrine Tumours of the Alimentary Tract - History and at Present"@en . "Histologick\u00E1 klasifikace neuroendokrinn\u00EDch n\u00E1dor\u016F (karcinoid\u016F) tr\u00E1vic\u00EDho \u00FAstroj\u00ED a s n\u00ED souvisej\u00EDc\u00ED n\u00E1zory na biologick\u00E9 chov\u00E1n\u00ED t\u011Bchto n\u00E1dor\u016F prod\u011Blaly v uplynul\u00FDch letech podstatn\u00E9 zm\u011Bny. Pokroky v pozn\u00E1n\u00ED biologie bun\u011Bk dif\u00FAzn\u00EDho endokrinn\u00EDho syst\u00E9mu a v klinick\u00E9 diagnostice a terapii n\u00E1dor\u016F k t\u011Bmto bu\u0148k\u00E1m histogeneticky bl\u00EDzk\u00FDm vedly k vytvo\u0159en\u00ED nov\u00E9 klasifikace zalo\u017Een\u00E9 na komplexn\u00EDm posouzen\u00ED n\u00E1doru, zahrnuj\u00EDc\u00EDm krom\u011B z\u00E1kladn\u00EDho mikroskopick\u00E9ho obrazu, imunohistologick\u00E9 detekce znak\u016F neuroendokrinn\u00ED diferenciace i ur\u010Den\u00ED jeho biologick\u00FDch vlastnost\u00ED podle lokalizace n\u00E1doru, mitotick\u00E9 a prolifera\u010Dn\u00ED aktivity n\u00E1dorov\u00FDch bun\u011Bk a klinicko-patologick\u00E9 korelace, vych\u00E1zej\u00EDc\u00ED z velikosti n\u00E1doru a rozsahu jeho r\u016Fstu. P\u0159esn\u00E9 za\u0159azen\u00ED n\u00E1doru do p\u0159\u00EDslu\u0161n\u00E9 kategorie je nezbytnou podm\u00EDnkou pro spr\u00E1vnou volbu dal\u0161\u00EDch diagnostick\u00FDch krok\u016F a pro ur\u010Den\u00ED optim\u00E1ln\u00ED terapeutick\u00E9 strategie."@cs . "3" . . . "Neuroendokrinn\u00ED n\u00E1dory tr\u00E1vic\u00EDho \u00FAstroj\u00ED - historie a sou\u010Dasnost"@cs . "Neuroendokrinn\u00ED n\u00E1dory tr\u00E1vic\u00EDho \u00FAstroj\u00ED - historie a sou\u010Dasnost"@cs . .