. "Suppl. 3" . "RIV/00216208:11120/08:00003796" . "385679" . "Functions of N-methyl-D-aspartate receptors are changed in some schizophrenic brain regions. The cause might be the changed expression of essential subunits or their accelerated internalization. While the decreased expression of NR1 subunit in mouse caused change in prepulse inhibition of acoustic startle, in rats we have not proved a deficit in the prepulse inhibition. In our work using antisense oligodeoxynucleotide for NMDA-NR1 separately or in combination with NR2A or NR2B, we affected expression of NR1 protein in the rat hippocampus. The changed expression of NR1 protein was compared with the mentioned parameter of behaviour."@en . "3"^^ . . . "1211-7579" . . "12" . "Ovliv\u0148uj\u00ED anti-NR2A/anti-NR2B oligodeoxynukleotidy hipokamp\u00E1ln\u00ED expresi proteinu NR1 podjednotky NMDA receptoru u dosp\u011Bl\u00E9ho potkana: pilotn\u00ED studie" . "Ovliv\u0148uj\u00ED anti-NR2A/anti-NR2B oligodeoxynukleotidy hipokamp\u00E1ln\u00ED expresi proteinu NR1 podjednotky NMDA receptoru u dosp\u011Bl\u00E9ho potkana: pilotn\u00ED studie" . . . "11120" . "P(1M0517), Z(AV0Z10300504)" . "CZ - \u010Cesk\u00E1 republika" . . . "http://www.tigis.cz/images/stories/psychiatrie/2008/suppl_03/18_Vrajova_Suppl_Psych_3_08.pdf" . . "animal model of schizophrenia; hypofunction of NMDA receptor; oligodeoxynucleotides for NMDA-NR1/NR2 subunits; prepulse inhibition of acoustic startle"@en . "Vrajov\u00E1, Monika" . . "Funkce N-methyl-D-aspart\u00E1tov\u00FDch receptor\u016F v n\u011Bkter\u00FDch oblastech mozku pacient\u016F trp\u00EDc\u00EDch schizofreni\u00ED jsou zm\u011Bn\u011Bn\u00E9. P\u0159\u00ED\u010Dinou m\u016F\u017Ee b\u00FDt zm\u011Bn\u011Bn\u00E1 exprese hlavn\u00EDch receptorov\u00FDch podjednotek nebo jejich zrychlen\u00E1 internalizace. Zat\u00EDmco sn\u00ED\u017Een\u00E1 exprese ubikvitern\u00ED receptorov\u00E9 NR1 podjednotky u my\u0161\u00ED zp\u016Fsobila zm\u011Bnu prepulzn\u00ED inhibice akustick\u00E9 \u00FAlekov\u00E9 reakce, u potkan\u016F jsme podobnou zm\u011Bnu neprok\u00E1zali. V na\u0161\u00ED pr\u00E1ci jsme u potkan\u016F ovliv\u0148ovali expresi NR1 proteinu pomoc\u00ED antisense oligodeoxynukleotid\u016F pro NMDA-NR1 a to samostatn\u011B nebo v kombinaci s NR2A \u010Di NR2B, p\u0159i\u010Dem\u017E jsme zm\u011Bny exprese NR1 proteinu porovn\u00E1vali se zm\u011Bnami uveden\u00E9ho parametru jejich chov\u00E1n\u00ED." . . "Psychiatrie" . . . "2"^^ . "RIV/00216208:11120/08:00003796!RIV12-MSM-11120___" . "Funkce N-methyl-D-aspart\u00E1tov\u00FDch receptor\u016F v n\u011Bkter\u00FDch oblastech mozku pacient\u016F trp\u00EDc\u00EDch schizofreni\u00ED jsou zm\u011Bn\u011Bn\u00E9. P\u0159\u00ED\u010Dinou m\u016F\u017Ee b\u00FDt zm\u011Bn\u011Bn\u00E1 exprese hlavn\u00EDch receptorov\u00FDch podjednotek nebo jejich zrychlen\u00E1 internalizace. Zat\u00EDmco sn\u00ED\u017Een\u00E1 exprese ubikvitern\u00ED receptorov\u00E9 NR1 podjednotky u my\u0161\u00ED zp\u016Fsobila zm\u011Bnu prepulzn\u00ED inhibice akustick\u00E9 \u00FAlekov\u00E9 reakce, u potkan\u016F jsme podobnou zm\u011Bnu neprok\u00E1zali. V na\u0161\u00ED pr\u00E1ci jsme u potkan\u016F ovliv\u0148ovali expresi NR1 proteinu pomoc\u00ED antisense oligodeoxynukleotid\u016F pro NMDA-NR1 a to samostatn\u011B nebo v kombinaci s NR2A \u010Di NR2B, p\u0159i\u010Dem\u017E jsme zm\u011Bny exprese NR1 proteinu porovn\u00E1vali se zm\u011Bnami uveden\u00E9ho parametru jejich chov\u00E1n\u00ED."@cs . "[EB6153E0E45E]" . . "\u0160\u0165astn\u00FD, Franti\u0161ek" . "4"^^ . "Do anti-NR2A/anti-NR2B oligodeoxynucleotides alter hippocampal protein expression of NR1 subunit/NMDA receptor in adult rat: preliminary study"@en . . . "Ovliv\u0148uj\u00ED anti-NR2A/anti-NR2B oligodeoxynukleotidy hipokamp\u00E1ln\u00ED expresi proteinu NR1 podjednotky NMDA receptoru u dosp\u011Bl\u00E9ho potkana: pilotn\u00ED studie"@cs . . . "Do anti-NR2A/anti-NR2B oligodeoxynucleotides alter hippocampal protein expression of NR1 subunit/NMDA receptor in adult rat: preliminary study"@en . . "Ovliv\u0148uj\u00ED anti-NR2A/anti-NR2B oligodeoxynukleotidy hipokamp\u00E1ln\u00ED expresi proteinu NR1 podjednotky NMDA receptoru u dosp\u011Bl\u00E9ho potkana: pilotn\u00ED studie"@cs .