"V dosp\u011Bl\u00E9m sav\u010D\u00EDm mozku se nach\u00E1zej\u00ED dv\u011B prim\u00E1rn\u00ED z\u00F3ny neurogeneze: gyrus dentatus a subventrikul\u00E1rn\u00ED z\u00F3na. Nov\u011B vznikaj\u00EDc\u00ED bu\u0148ky se daj\u00ED edentifikovat pomoc\u00ED imunohistochemie ozna\u010Den\u00EDm mitotick\u00E9ho markertu Ki-67 nebo za pomoci bromdeoxiuridinu (BrdU).BrdU je tymidov\u00FD analog, kter\u00FD se v\u00E1\u017Ee na DNA v pr\u016Fb\u011Bhu d\u011Blen\u00ED bu\u0148ky. V na\u0161\u00ED pilotn\u00ED studii jsme sledovali \u00FA\u010Dinek aplikace MDMA a citalopramu na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u011B vznikl\u00FDch neuron\u016F v gyrus dentatus u potkana. Semikvantifikace BrdU pozitivn\u00EDch bun\u011Bk v gyrus dentatus ukazuje, \u017Ee t\u00FDdenn\u00ED aplikace MDMA (5 mg/kg, 2x denn\u011B) sni\u017Euje po\u010Det BrdU pozitivn\u00EDch bun\u011Bk ve srovn\u00E1n\u00ED s kontrolou. Aplikace citalopramu (30 mg/kg) nem\u00E1 \u017E\u00E1dn\u00FD vliv na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u00FDch bun\u011Bk v hipokampu potkana. Doposud nen\u00ED zn\u00E1mo, pro\u010D MDMA, kter\u00E1 p\u016Fsob\u00ED stejn\u011B jako citalopram na serotoninov\u00FD transport, sni\u017Euje neurogenezi."@cs . "3"^^ . "12" . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . "P(NR8785)" . "The Effect of 3,4-Methylenedioxymethamphetamine (Ecstasy) and Citalopram on Survival of new Generated Cells in Adult Rat Hippocampus - Pilot Study"@en . "MDMA; citalopram; neurogenesis"@en . . "3"^^ . "V dosp\u011Bl\u00E9m sav\u010D\u00EDm mozku se nach\u00E1zej\u00ED dv\u011B prim\u00E1rn\u00ED z\u00F3ny neurogeneze: gyrus dentatus a subventrikul\u00E1rn\u00ED z\u00F3na. Nov\u011B vznikaj\u00EDc\u00ED bu\u0148ky se daj\u00ED edentifikovat pomoc\u00ED imunohistochemie ozna\u010Den\u00EDm mitotick\u00E9ho markertu Ki-67 nebo za pomoci bromdeoxiuridinu (BrdU).BrdU je tymidov\u00FD analog, kter\u00FD se v\u00E1\u017Ee na DNA v pr\u016Fb\u011Bhu d\u011Blen\u00ED bu\u0148ky. V na\u0161\u00ED pilotn\u00ED studii jsme sledovali \u00FA\u010Dinek aplikace MDMA a citalopramu na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u011B vznikl\u00FDch neuron\u016F v gyrus dentatus u potkana. Semikvantifikace BrdU pozitivn\u00EDch bun\u011Bk v gyrus dentatus ukazuje, \u017Ee t\u00FDdenn\u00ED aplikace MDMA (5 mg/kg, 2x denn\u011B) sni\u017Euje po\u010Det BrdU pozitivn\u00EDch bun\u011Bk ve srovn\u00E1n\u00ED s kontrolou. Aplikace citalopramu (30 mg/kg) nem\u00E1 \u017E\u00E1dn\u00FD vliv na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u00FDch bun\u011Bk v hipokampu potkana. Doposud nen\u00ED zn\u00E1mo, pro\u010D MDMA, kter\u00E1 p\u016Fsob\u00ED stejn\u011B jako citalopram na serotoninov\u00FD transport, sni\u017Euje neurogenezi." . "Vliv 3,4-methylendioxymetamfetaminu (ext\u00E1ze) a citalopramu na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u011B vznikl\u00FDch bun\u011Bk v hipokampu dosp\u011Bl\u00FDch potkan\u016F - pilotn\u00ED studie"@cs . . . "RIV/00216208:11120/08:00003638!RIV12-MZ0-11120___" . . . "Psychiatrie" . "Two primary zone of neurognesis were identified in the adult mammal brain. These zones are localized in the dentate gyrus and the subventricular zone. New generated cells can be imunohistochemically stained against the mitotic marker Ki-67 or by bromdeoxyridine (BrdU). BrdU is a tymide analog, which is incorporated into the DNA during cell division. In our pilot study, we monitor the effect of MDMA and citalopram on survival of newly generated neurons in the dentate gyrus of rats. Semi-quantification of BrdU positive cells in the dentate gyrus determined that the application of MDMA (5 mg/kg, 2x day) decreased the number of BrdU-positive cells compared to the control group. The application of citalopram (30 mg/kg, 2x day) did not influence the survival of new cells in rat hippocampus. It is not yet clear why MDMA, which similar to citalopram inhibits transporter for serotonin, decreases the neurogenesis."@en . "Vliv 3,4-methylendioxymetamfetaminu (ext\u00E1ze) a citalopramu na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u011B vznikl\u00FDch bun\u011Bk v hipokampu dosp\u011Bl\u00FDch potkan\u016F - pilotn\u00ED studie"@cs . . "CZ - \u010Cesk\u00E1 republika" . "Vliv 3,4-methylendioxymetamfetaminu (ext\u00E1ze) a citalopramu na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u011B vznikl\u00FDch bun\u011Bk v hipokampu dosp\u011Bl\u00FDch potkan\u016F - pilotn\u00ED studie" . "403542" . . . "Buben\u00EDkov\u00E1-Vale\u0161ov\u00E1, V\u011Bra" . . "The Effect of 3,4-Methylenedioxymethamphetamine (Ecstasy) and Citalopram on Survival of new Generated Cells in Adult Rat Hippocampus - Pilot Study"@en . . . "http://www.tigis.cz/images/stories/psychiatrie/2008/02/11_Bubenikova-Valesova_Psychiatrie_2_2008.pdf" . . "[9A11476F5AFD]" . . . "RIV/00216208:11120/08:00003638" . "1211-7579" . . "11120" . "5"^^ . "Vliv 3,4-methylendioxymetamfetaminu (ext\u00E1ze) a citalopramu na p\u0159e\u017E\u00EDv\u00E1n\u00ED nov\u011B vznikl\u00FDch bun\u011Bk v hipokampu dosp\u011Bl\u00FDch potkan\u016F - pilotn\u00ED studie" . "2" . .