"354933" . . "11120" . "Langin, D." . "9" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "000253779800022" . "Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity" . . . "Transkriptom tukov\u00E9 tk\u00E1n\u011B prokazuje patologick\u00FD v\u00FDznam extracelul\u00E1rn\u00ED matrix u lidsk\u00E9 obezity"@cs . "Basdevant, A." . . . "We analyzed the transcriptomic signature of the subcutaneous in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. The analyses highlighted a significant up-regulation of genes and biological themes related to extracellular matrix (ECM) constituents, including members of the integrin family, and suggested that these elements could play a major mediating role in a chain of interactions that connect local inflammatory phenomena to the alteration of white adipose tissue metabolic functions in obese subjects." . "Analyzovali jsme transkriptom podko\u017En\u00ED tukov\u00E9 tk\u00E1n\u011B u obesn\u00EDch jedinc\u016F, v situaci stabilizovan\u00E9 v\u00E1hy a po redukc\u00ED v\u00E1hy po bariatrick\u00E9 operaci. Analyza uk\u00E1zala v\u00FDznamnou positivn\u00ED regulaci gen\u016F a biologick\u00FDch struktur, kter\u00E9 maj\u00ED vztah ke slo\u017Ek\u00E1m extracelul\u00E1rn\u00ED matrix (ECM), v\u010Detn\u011B \u010Dlen\u016F skupiny integrin\u016F, nasv\u011Bd\u010Duje tomu, \u017Ee tyto prvky mohou hr\u00E1t d\u016Fle\u017Eitou zprost\u0159edkuj\u00EDc\u00ED roli v \u0159et\u011Bzci interakc\u00ED spojuj\u00EDc\u00EDch lok\u00E1ln\u00ED z\u00E1n\u011Btliv\u00E9 jevy se zm\u011Bnami metabolick\u00E9 funkce b\u00EDl\u00E9 tukov\u00E9 tk\u00E1n\u011B u obesn\u00EDch jedinc\u016F."@cs . "Lacasa, D." . "Z(MSM0021620814)" . "Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity" . "Guerre-Millo, M." . "Poitou, C." . "RIV/00216208:11120/08:00001146" . "Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity"@en . . . "Clement, K." . "14"^^ . "1474-760X" . "We analyzed the transcriptomic signature of the subcutaneous in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. The analyses highlighted a significant up-regulation of genes and biological themes related to extracellular matrix (ECM) constituents, including members of the integrin family, and suggested that these elements could play a major mediating role in a chain of interactions that connect local inflammatory phenomena to the alteration of white adipose tissue metabolic functions in obese subjects."@en . "32"^^ . . . . . . . "1" . . . "Cremer, I." . . "Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity"@en . . "Achard, V." . "Tordjman, J." . "Henegar, C." . . "Genome Biology" . . "RIV/00216208:11120/08:00001146!RIV09-MSM-11120___" . . "Transkriptom tukov\u00E9 tk\u00E1n\u011B prokazuje patologick\u00FD v\u00FDznam extracelul\u00E1rn\u00ED matrix u lidsk\u00E9 obezity"@cs . . "Gene-Expression; Liver Fibrosis; Weight-Loss; Interaction Networks; Pulmonary-Fibrosis; Microarray Data; Energy-Balance; Up-Regulation; In-Vivo; Inflammation"@en . . "Viguerie, N." . "Bedossa, P." . "1"^^ . "Zucker, J.D.." . "[8DAEDF114E39]" . "\u0160tich, Vladim\u00EDr" .