"RIV/00216208:11120/08:00000830!RIV09-MSM-11120___" . "Role microRNA u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED"@cs . "RIV/00216208:11120/08:00000830" . "Role microRNA u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED" . "50" . "393146" . "Role microRNA u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED"@cs . . "Ned\u00E1vn\u00E9 experiment\u00E1ln\u00ED pr\u00E1ce upozornily na enormn\u00ED v\u00FDznam tzv. mikroRNA v posttranskrip\u010Dn\u00ED regulaci exprese gen\u016F. MikroRNA jsou cca 22-nukleotid\u016F dlouh\u00E9 jedno\u0159et\u011Bzcov\u00E9 nukleov\u00E9 kyseliny pat\u0159\u00EDc\u00ED do rodiny tzv. nek\u00F3duj\u00EDc\u00EDch RNA. MikroRNA navozuj\u00ED degradaci messenger RNA, a tak inhibuj\u00ED synt\u00E9zu protein\u016F na transla\u010Dn\u00ED \u00FArovni. Jedin\u00FD specifick\u00FD typ mikroRNA reguluje expresi cel\u00E9ho \u0159et\u011Bzce gen\u016F k\u00F3duj\u00EDc\u00EDch funk\u010Dn\u011B nebo struktur\u00E1ln\u011B souvisej\u00EDc\u00ED proteiny. Experiment\u00E1ln\u00ED pr\u00E1ce uk\u00E1zaly, \u017Ee miRNA jsou kl\u00ED\u010Dov\u00E9 regul\u00E1tory gen\u016F ovliv\u0148uj\u00EDc\u00EDch r\u016Fst a hypertrofii kardiomyocyt\u016F, jejich kontraktiln\u00ED funkci a elektrickou vodivost. Tento p\u0159ehledn\u00FD \u010Dl\u00E1nek shrnuje sou\u010Dasn\u00E9 poznatky o v\u00FDznamu mikroRNA v srde\u010Dn\u00EDm v\u00FDvoji a patogenezi kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED."@cs . "11120" . "1"^^ . "[3984FD418EB5]" . "12" . "2"^^ . . . . . . "0010-8650" . "CZ - \u010Cesk\u00E1 republika" . "Cor et Vasa" . "4"^^ . "Z(MSM0021620817)" . . . . "Vondr\u00E1k, Karel" . "MicroRNA in cardiovascular diseases"@en . . "Role microRNA u kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED" . . . "microRNA; cardiovascular disease"@en . . "This paper summarizes current knowledge on role of microRNA in cardiac hypertrophy, heart failure, ischemia and arrhythmias."@en . . "P\u011Bni\u010Dka, Martin" . "MicroRNA in cardiovascular diseases"@en . "Ned\u00E1vn\u00E9 experiment\u00E1ln\u00ED pr\u00E1ce upozornily na enormn\u00ED v\u00FDznam tzv. mikroRNA v posttranskrip\u010Dn\u00ED regulaci exprese gen\u016F. MikroRNA jsou cca 22-nukleotid\u016F dlouh\u00E9 jedno\u0159et\u011Bzcov\u00E9 nukleov\u00E9 kyseliny pat\u0159\u00EDc\u00ED do rodiny tzv. nek\u00F3duj\u00EDc\u00EDch RNA. MikroRNA navozuj\u00ED degradaci messenger RNA, a tak inhibuj\u00ED synt\u00E9zu protein\u016F na transla\u010Dn\u00ED \u00FArovni. Jedin\u00FD specifick\u00FD typ mikroRNA reguluje expresi cel\u00E9ho \u0159et\u011Bzce gen\u016F k\u00F3duj\u00EDc\u00EDch funk\u010Dn\u011B nebo struktur\u00E1ln\u011B souvisej\u00EDc\u00ED proteiny. Experiment\u00E1ln\u00ED pr\u00E1ce uk\u00E1zaly, \u017Ee miRNA jsou kl\u00ED\u010Dov\u00E9 regul\u00E1tory gen\u016F ovliv\u0148uj\u00EDc\u00EDch r\u016Fst a hypertrofii kardiomyocyt\u016F, jejich kontraktiln\u00ED funkci a elektrickou vodivost. Tento p\u0159ehledn\u00FD \u010Dl\u00E1nek shrnuje sou\u010Dasn\u00E9 poznatky o v\u00FDznamu mikroRNA v srde\u010Dn\u00EDm v\u00FDvoji a patogenezi kardiovaskul\u00E1rn\u00EDch onemocn\u011Bn\u00ED." .