"Sato-Matsumura, K. C." . "Beckert, W." . "British Journal of Dermatology" . "0007-0963" . "Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas"@en . . . "000254122100016" . "8"^^ . "400423" . "Kallajoki, M." . . "158" . . "Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas" . "Weber, F." . "Sinemus, K." . "Csik\u00F3s, M." . "Bauer, J. W." . . "K\u00F6nigov\u00E1, Radana" . . "Recesivn\u00ED dystrofick\u00E1 epidermolyza bulozn\u00ED (RDEB) m\u00E1 zv\u00FD\u0161en\u00E9 riziko vzniku progresivn\u00EDho a metastazuj\u00EDc\u00EDho spinocelul\u00E1rn\u00EDho karcinomu k\u016F\u017Ee (SCC). Nen\u00ED jasn\u00E9, pro\u010D tyto karcinomy jsou agresivn\u011Bj\u0161\u00ED ne\u017E ojedin\u011Ble se vyskytuj\u00EDc\u00ED. Matrix metalloproteniaz pat\u0159\u00ED mezi endopeptidasy, kter\u00E9 podporuj\u00ED r\u016Fst, invazi a metastazuj\u00ED. Role MMP u SCC u recesisn\u00ED dystrofick\u00E9 epidermolyzy bulozn\u00ED nen\u00ED zn\u00E1ma. C\u00EDlem pr\u00E1ce je zkoumat expresi MMP-7, MMP-13 a MMP-9 u RDEB ve srovn\u00E1n\u00ED se sporadick\u00FDm SCC a nemoc\u00ED Bowen. K Immunohistochemick\u00E9 analyze byly pou\u017Eity monoklon\u00E1ln\u00ED protil\u00E1tky (MMP-7, MMP-9, MMP-13) a E-cadherin a syndecan-1. V\u00FDsledky studie uk\u00E1zaly MMP-7 a MMP-13 jako specifick\u00E9 markry progrese bun\u011Bk SCC a potencion\u00E1ln\u00ED c\u00EDle p\u0159i l\u00E9\u010Db\u011B karcinomu v p\u0159\u00EDpadech recesivn\u00ED dystrofick\u00E9 epidermalyzy bulozn\u00ED."@cs . "Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas"@en . . . "11120" . "Exprese matrix metalloproteinas (MMP)-7 a (MMP)-13 n\u00E1dorov\u00FDmi bu\u0148kami spinocelul\u00E1rn\u00EDho karcinomu p\u0159i epidermolysis bullosa."@cs . "Mirtti, T." . "Exprese matrix metalloproteinas (MMP)-7 a (MMP)-13 n\u00E1dorov\u00FDmi bu\u0148kami spinocelul\u00E1rn\u00EDho karcinomu p\u0159i epidermolysis bullosa."@cs . "metalloproteinases; squamous cell carcinoma; recessive dystrophic epidermolysis bullosa; E-cadherin; syndecan-1"@en . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas" . . "[9730180E2C5D]" . . "S" . "Background\u00A0Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC). It is unclear why these SCC behave more aggressively than sporadic SCC. Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC. The role of MMP in RDEB-associated SCC is not known.Objectives\u00A0 To investigate the expression of MMP-7, MMP-13 and MMP-9 in RDEB-associated SCC in comparison with sporadic SCC and Bowen's disease.Methods\u00A0 Immunohistochemical analysis of 25 RDEB-associated SCC, 61 sporadic SCC and 28 sporadic lesions of Bowen's disease was carried out using monoclonal antibodies for MMP-7, MMP-9, MMP-13 and E-cadherin and syndecan-1.Results\u00A0 MMP-7 was detected in all RDEB-associated SCC, in tumour cells within the invasive edge, where E-cadherin and syndecan-1 were markedly diminished or absent. MMP-7 expression was also observed in" . . . "Sawamura, D." . "RIV/00216208:11120/08:00000811!RIV09-MSM-11120___" . "4" . "14"^^ . "RIV/00216208:11120/08:00000811" . . "K\u00E4h\u00E4ri, V. M." . "Kivisaari, A. K." . . . "McGrath, J. A" . "Background\u00A0Patients with recessive dystrophic epidermolysis bullosa (RDEB) have an increased risk of developing rapidly progressive and metastatic cutaneous squamous cell carcinomas (SCC). It is unclear why these SCC behave more aggressively than sporadic SCC. Matrix metalloproteinases (MMP) are a family of endopeptidases that contribute to growth, invasion and metastasis of SCC. The role of MMP in RDEB-associated SCC is not known.Objectives\u00A0 To investigate the expression of MMP-7, MMP-13 and MMP-9 in RDEB-associated SCC in comparison with sporadic SCC and Bowen's disease.Methods\u00A0 Immunohistochemical analysis of 25 RDEB-associated SCC, 61 sporadic SCC and 28 sporadic lesions of Bowen's disease was carried out using monoclonal antibodies for MMP-7, MMP-9, MMP-13 and E-cadherin and syndecan-1.Results\u00A0 MMP-7 was detected in all RDEB-associated SCC, in tumour cells within the invasive edge, where E-cadherin and syndecan-1 were markedly diminished or absent. MMP-7 expression was also observed in"@en . "1"^^ . "Shimizu, H." .