"Kr\u0161iak, Miloslav" . . "Tato pr\u00E1ce popisuje \u00FA\u010Dinky nov\u00E9ho alfa2-adrenergn\u00EDho agonisty naftylmedetomidinu u my\u0161\u00ED. Tato l\u00E1tka byla pod\u00E1v\u00E1na v d\u00E1vk\u00E1ch 150-1200 mikrog/kg i.p. u my\u0161\u00ED a jej\u00ED \u00FA\u010Dinky sledov\u00E1ny pomoc\u00ED aktivitn\u00ED klece a testu soci\u00E1ln\u00EDho konfliktu. Naftylmedetomidin velmi v\u00FDrazn\u011B tlumil agresivitu v d\u00E1vk\u00E1ch, kter\u00E9 je\u0161t\u011B nezp\u016Fsobovaly sedaci. Dal\u0161\u00EDm zaj\u00EDmav\u00FDch zji\u0161t\u011Bn\u00EDm bylo, \u017Ee atipamezol, alfa2-adrenergn\u00ED agonista, byl schopen pouze \u010D\u00E1ste\u010Dn\u011B antagonizovat \u00FA\u010Dinky naftylmedetomidinu na sedaci. Takto vysoce selektivn\u00ED antiagresivn\u00ED \u00FA\u010Dinek je pozorov\u00E1n velmi z\u0159\u00EDdka. Tato pr\u00E1ce tak poukazuje na potenci\u00E1ln\u00ED mo\u017Enosti naftlymedetomidinu ve zvl\u00E1d\u00E1n\u00ED agresivn\u00EDch stav\u016F."@cs . . . . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice" . "Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, with a more selective alpha(2)-AR activity. Behavioral effects of naphthylmedetomidine (150-1200 microg/kg i.p.) were studied in the activity cage and in the social conflict tests in mice. Naphthylmedetomidine dose dependently decreased aggressive behavior during social conflict in aggressive mice with significant reduction already at the lowest doses tested (150 microg/kg), whereas locomotion and social investigation were significantly decreased only after four times bigger dose of naphthylmedet"@en . . "P(GP305/05/P003), P(NR8508), Z(MSM0021620816)" . . "RIV/00216208:11120/08:00000555" . "Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice" . "[0C1AE0CB2ED0]" . . . "Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice"@en . "Aggresive Behavior" . "394176" . . "Selective antiaggressive effect of an alpha-2 adrenoceptor agonist naphthylmedetomidine in mice"@en . . "Selektivn\u00ED antiagresivn\u00ED \u00FA\u010Dinek alfa2-adrenergn\u00EDho agonisty naftylmedetomidinu u my\u0161\u00ED"@cs . . "0096-140X" . "10"^^ . "RIV/00216208:11120/08:00000555!RIV09-GA0-11120___" . "Hess, Ladislav" . . "34" . "Votava, Martin" . . "4" . "3"^^ . . . "000256645800005" . "Alpha-2 adrenoceptors (alpha(2)-ARs) are critically involved in regulating neurotransmitter release from sympathetic nerves and neurons and play an important role in the regulation of awareness, arousal and vigilance. In our recent study, dexmedetomidine, a full alpha(2)-AR agonist, produced antiaggressive effects in the social conflict test in mice at doses that were twice smaller than those producing sedation. The aim of this study was to ascertain antiaggressive effect of a novel drug naphthylmedetomidine, with a more selective alpha(2)-AR activity. Behavioral effects of naphthylmedetomidine (150-1200 microg/kg i.p.) were studied in the activity cage and in the social conflict tests in mice. Naphthylmedetomidine dose dependently decreased aggressive behavior during social conflict in aggressive mice with significant reduction already at the lowest doses tested (150 microg/kg), whereas locomotion and social investigation were significantly decreased only after four times bigger dose of naphthylmedet" . "Selektivn\u00ED antiagresivn\u00ED \u00FA\u010Dinek alfa2-adrenergn\u00EDho agonisty naftylmedetomidinu u my\u0161\u00ED"@cs . "2"^^ . . "11120" . "naphthylmedetomidine; atipamezole; animal behavior; aggression; alpha-2 adrenoceptor"@en . . . .