. . "Schutov\u00E1, Barbora" . . . "methamphetamine; flurothyl; seizures; gender; estrous cycle"@en . "The aim of the present study was to investigate whether sensitivity to flurothyl seizures after an acute methamphetamine (MA) administration is different in prenatally MA-exposed adult rats than in controls without prenatal drug exposure. Adult male and female rats exposed prenatally to MA (5mg/kg), saline or neither (controls) were divided into groups; one group received acute MA (1mg/kg s.c.) injection and the other group received saline. Rats were then challenged with flurothyl at a constant flow rate to induce seizures. The threshold of the first focal clonus, clonic seizures and tonic-clonic seizures were analyzed. EFFECTS OF PRENATAL DRUG EXPOSURE: In animals without acute MA administration prior to seizure testing, prenatal MA exposure decreased threshold of the first clonus relative to control animals. This decrease in threshold was not apparent in groups pretreated with acute MA injection."@en . "RIV/00216208:11120/08:00000550" . "Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?"@en . "000253038600004" . . "1" . "11120" . . "Bern\u00E1\u0161kov\u00E1, Kl\u00E1ra" . "0920-1211" . . "NL - Nizozemsko" . . . "7"^^ . "Mat\u011Bjovsk\u00E1, Iveta" . "[57BEA9FB6FC4]" . "364120" . . . . "Epilepsy Research" . . "RIV/00216208:11120/08:00000550!RIV09-GA0-11120___" . . "Zji\u0161\u0165ov\u00E1n\u00EDm citlivosti k epileptick\u00FDm z\u00E1chvat\u016Fm po aplikaci flurothylu jsme testovali funk\u010Dnost GABA syst\u00E9mu u dosp\u011Bl\u00FDch samc\u016F prenat\u00E1ln\u011B exponovan\u00FDch metamfetaminu (MA). V\u0161em skupin\u00E1m, tedy potomk\u016Fm matek s drogou i kontrol\u00E1m, jsme pod\u00E1vali akutn\u00ED aplikaci MA v d\u00E1vce 1 mg/kg. Prenat\u00E1ln\u00ED expozice MA zkracuje latenci prvn\u00EDho z\u00E1\u0161kubu po expozici flurothylu u zv\u00ED\u0159at bez akutn\u00ED aplikace MA. Toto sn\u00ED\u017Een\u00ED prahu pro vznik k\u0159e\u010D\u00ED nebylo patrn\u00E9 po aplikaci akutn\u00ED d\u00E1vky MA. Akutn\u00ED aplikace MA (ve v\u0161ech skupin\u00E1ch) prodlu\u017Eovala latenci vzniku klonick\u00FDch i tonicko-klonick\u00FDch z\u00E1chvat\u016F. Na\u0161e v\u00FDsledky ukazuj\u00ED, \u017Ee akutn\u00ED pod\u00E1n\u00ED MA sni\u017Euje \u00FA\u010Dinek prenat\u00E1ln\u00ED aplikace MA na zv\u00FD\u0161en\u00ED pohotovosti ke k\u0159e\u010D\u00EDm. Tyto v\u00FDsledky sv\u011Bd\u010D\u00ED pro zm\u011Bn\u011Bnou citlivost k MA, ikdy\u017E \u00FA\u010Dinek je opa\u010Dn\u00FD ne\u017E jsme o\u010Dek\u00E1vali. V\u00FDsledky byly rovn\u011B\u017E z\u00E1visl\u00E9 na pohlav\u00ED a estr\u00E1ln\u00EDm cyklu samic."@cs . . "\u0160lamberov\u00E1, Romana" . "4"^^ . "78" . . "P(1M0517), P(GA305/06/0283), Z(MSM0021620816)" . "Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?" . . . . "Ovliv\u0148uje prenat\u00E1ln\u00ED expozice metamfetaminu z\u00E1chvatovou pohotovost laboratorn\u00EDch pokan\u016F po aplikaci stejn\u00E9 drogy v dosp\u011Blosti?"@cs . "4"^^ . "Ovliv\u0148uje prenat\u00E1ln\u00ED expozice metamfetaminu z\u00E1chvatovou pohotovost laboratorn\u00EDch pokan\u016F po aplikaci stejn\u00E9 drogy v dosp\u011Blosti?"@cs . "Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?" . . "Does prenatal methamphetamine exposure affect seizure susceptibility in adult rats with acute administration of the same drug?"@en . "The aim of the present study was to investigate whether sensitivity to flurothyl seizures after an acute methamphetamine (MA) administration is different in prenatally MA-exposed adult rats than in controls without prenatal drug exposure. Adult male and female rats exposed prenatally to MA (5mg/kg), saline or neither (controls) were divided into groups; one group received acute MA (1mg/kg s.c.) injection and the other group received saline. Rats were then challenged with flurothyl at a constant flow rate to induce seizures. The threshold of the first focal clonus, clonic seizures and tonic-clonic seizures were analyzed. EFFECTS OF PRENATAL DRUG EXPOSURE: In animals without acute MA administration prior to seizure testing, prenatal MA exposure decreased threshold of the first clonus relative to control animals. This decrease in threshold was not apparent in groups pretreated with acute MA injection." . . . .