"N, V" . "ACE inhibition results in secondary prevention of coronary artery disease (CAD) through different mechanisms including improvement of endothelial dysfunction. The Perindopril-Function of the Endothelium in Coronary artery disease Trial (PERFECT) evaluated whether long-term administration of perindopril improves endothelial dysfunction. PERFECT is a 3-year double blind randomised placebo controlled trial to determine the effect of perindopril 8 mg once daily on brachial artery endothelial function in patients with stable CAD without clinical heart failure. Endothelial function in response to ischaemia was assessed using ultrasound. Primary endpoint was difference in flow-mediated vasodilatation (FMD) assessed at 36 months. In 20 centers, 333 patients randomly received perindopril or matching placebo. Ischemia-induced FMD was 2.7% (SD 2.6). In the perindopril group FMD went from 2.6% at baseline to 3.3% at 36 months and in the placebo group from 2.8 to 3.0%. Change in FMD after 36 month treatment was 0."@en . . "Bots, M. L." . "408404" . . . . "ACE inhibition and endothelial function: Main findings of PERFECT, a sub-study of the EUROPA trial"@en . "21" . "Widimsk\u00FD, Petr" . . . "4" . "000249402800007" . . "[694FB5E07C8D]" . "NL - Nizozemsko" . "2"^^ . . "ACE inhibition; Atherosclerosis; Brachial reactivity; Cardiovascular disease prevention; Coronary heart disease; Endothelial function"@en . . "ACE inhibition and endothelial function: Main findings of PERFECT, a sub-study of the EUROPA trial" . "45"^^ . . . . "11120" . . "http://dx.doi.org/10.1007/s10557-007-6041-3" . . . "10.1007/s10557-007-6041-3" . "ACE inhibition and endothelial function: Main findings of PERFECT, a sub-study of the EUROPA trial" . "0920-3206" . "Cardiovascular Drugs and Therapy" . . "ACE inhibition and endothelial function: Main findings of PERFECT, a sub-study of the EUROPA trial"@en . "\u0160pa\u010Dek, Rudolf" . "11"^^ . . "ACE inhibition results in secondary prevention of coronary artery disease (CAD) through different mechanisms including improvement of endothelial dysfunction. The Perindopril-Function of the Endothelium in Coronary artery disease Trial (PERFECT) evaluated whether long-term administration of perindopril improves endothelial dysfunction. PERFECT is a 3-year double blind randomised placebo controlled trial to determine the effect of perindopril 8 mg once daily on brachial artery endothelial function in patients with stable CAD without clinical heart failure. Endothelial function in response to ischaemia was assessed using ultrasound. Primary endpoint was difference in flow-mediated vasodilatation (FMD) assessed at 36 months. In 20 centers, 333 patients randomly received perindopril or matching placebo. Ischemia-induced FMD was 2.7% (SD 2.6). In the perindopril group FMD went from 2.6% at baseline to 3.3% at 36 months and in the placebo group from 2.8 to 3.0%. Change in FMD after 36 month treatment was 0." . "RIV/00216208:11120/07:00003082" . . "RIV/00216208:11120/07:00003082!RIV12-MSM-11120___" . .