"Autologn\u00ED transplantace krvetvorn\u00FDch bun\u011Bk (ASCT) hraje d\u016Fle\u017Eitou roli v terapii symptomatick\u00FDch pacient\u016F s mnoho\u010Detn\u00FDm myelomem (MM). C\u00EDlem pr\u00E1ce bylo retrospektivn\u011B analyzovat v\u00FDsledky transplanta\u010Dn\u00ED l\u00E9\u010Dby u 495 pacient\u016F s MM z 6 transplanta\u010Dn\u00EDch center na z\u00E1klad\u011B dat z N\u00E1rodn\u00EDho registru transplantac\u00ED krvetvorn\u00FDch bun\u011Bk \u010Cesk\u00E9 republiky se zam\u011B\u0159en\u00EDm na identifikaci parametr\u016F v\u00FDznamn\u00FDch pro dobu do progrese (PFS) a celkov\u00E9 p\u0159e\u017Eit\u00ED (OS) pacient\u016F po transplantaci. Pacienti byli transplantov\u00E1ni v obdob\u00ED 1994-2005, medi\u00E1n v\u011Bku byl 56 let, zastoupen\u00ED klinick\u00FDch stadi\u00ED dle Durie-Salmona bylo n\u00E1sleduj\u00EDc\u00ED: I - 8%, II - 29%, III- 63%. Celkem 411 pacient\u016F (83 %) m\u011Blo ASCT do 1 roku od stanoven\u00ED diagn\u00F3zy. Medi\u00E1n doby sledov\u00E1n\u00ED po transplantaci byl 33,3 m\u011Bs\u00EDce. Peritranspla\u010Dn\u00ED mortalita do dne +100 byla 1 %, medi\u00E1n p\u0159ihojen\u00ED \u0161t\u011Bpu byl 12 dn\u00ED. L\u00E9\u010Debn\u00E9 odpov\u011Bdi po transplantaci dle krit\u00E9ri\u00ED EBMT byly uvedeny u 149 pacient\u016F (30 %), z toho bylo u 94 pacient\u016F dosa\u017Eeno kompletn\u00ED remise. Medi\u00E1n PFS od transplantace byl"@cs . . "Autologous transplantation in 495 multiple myeloma patients - Analysis from the Czech National Registry of Hematopoietic Stem Cell Transplantation"@en . . "7"^^ . "Autologn\u00ED transplantace krvetvorn\u00FDch bun\u011Bk (ASCT) hraje d\u016Fle\u017Eitou roli v terapii symptomatick\u00FDch pacient\u016F s mnoho\u010Detn\u00FDm myelomem (MM). C\u00EDlem pr\u00E1ce bylo retrospektivn\u011B analyzovat v\u00FDsledky transplanta\u010Dn\u00ED l\u00E9\u010Dby u 495 pacient\u016F s MM z 6 transplanta\u010Dn\u00EDch center na z\u00E1klad\u011B dat z N\u00E1rodn\u00EDho registru transplantac\u00ED krvetvorn\u00FDch bun\u011Bk \u010Cesk\u00E9 republiky se zam\u011B\u0159en\u00EDm na identifikaci parametr\u016F v\u00FDznamn\u00FDch pro dobu do progrese (PFS) a celkov\u00E9 p\u0159e\u017Eit\u00ED (OS) pacient\u016F po transplantaci. Pacienti byli transplantov\u00E1ni v obdob\u00ED 1994-2005, medi\u00E1n v\u011Bku byl 56 let, zastoupen\u00ED klinick\u00FDch stadi\u00ED dle Durie-Salmona bylo n\u00E1sleduj\u00EDc\u00ED: I - 8%, II - 29%, III- 63%. Celkem 411 pacient\u016F (83 %) m\u011Blo ASCT do 1 roku od stanoven\u00ED diagn\u00F3zy. Medi\u00E1n doby sledov\u00E1n\u00ED po transplantaci byl 33,3 m\u011Bs\u00EDce. Peritranspla\u010Dn\u00ED mortalita do dne +100 byla 1 %, medi\u00E1n p\u0159ihojen\u00ED \u0161t\u011Bpu byl 12 dn\u00ED. L\u00E9\u010Debn\u00E9 odpov\u011Bdi po transplantaci dle krit\u00E9ri\u00ED EBMT byly uvedeny u 149 pacient\u016F (30 %), z toho bylo u 94 pacient\u016F dosa\u017Eeno kompletn\u00ED remise. Medi\u00E1n PFS od transplantace byl" . . "Autologn\u00ED transplantace u 495 pacient\u016F s mnoho\u010Detn\u00FDm myelomem - anal\u00FDza dat z N\u00E1rodn\u00EDho registru transplantac\u00ED krvetvorn\u00FDch bun\u011Bk \u010Cesk\u00E9 republiky" . "RIV/00216208:11120/07:00002150!RIV11-MSM-11120___" . "21"^^ . "Autologn\u00ED transplantace u 495 pacient\u016F s mnoho\u010Detn\u00FDm myelomem - anal\u00FDza dat z N\u00E1rodn\u00EDho registru transplantac\u00ED krvetvorn\u00FDch bun\u011Bk \u010Cesk\u00E9 republiky"@cs . . . . . . . "411098" . . "P(NR8223), S, V" . "Koz\u00E1k, Tom\u00E1\u0161" . . . "Krej\u010D\u00ED, M." . "2" . "Autologn\u00ED transplantace u 495 pacient\u016F s mnoho\u010Detn\u00FDm myelomem - anal\u00FDza dat z N\u00E1rodn\u00EDho registru transplantac\u00ED krvetvorn\u00FDch bun\u011Bk \u010Cesk\u00E9 republiky"@cs . "Autologn\u00ED transplantace u 495 pacient\u016F s mnoho\u010Detn\u00FDm myelomem - anal\u00FDza dat z N\u00E1rodn\u00EDho registru transplantac\u00ED krvetvorn\u00FDch bun\u011Bk \u010Cesk\u00E9 republiky" . "RIV/00216208:11120/07:00002150" . . . . . . "1213-5763" . "1"^^ . "CZ - \u010Cesk\u00E1 republika" . "11120" . "Autologous transplantation in 495 multiple myeloma patients - Analysis from the Czech National Registry of Hematopoietic Stem Cell Transplantation"@en . "[A22F96F6D65E]" . "13" . "Autologous stem cell transplantation; Complete response; Multiple myeloma; Prognostic factors"@en . . "Autologous stem cell transplantation (ASCT) has an important role in the treatment of symptomatic multiple myeloma (MM) patients. The aim of our study was to analyse retrospectively the results of ASCT in 495 MM patients from the Czech National Registry of Hematopoietic Stem Cell Transplantation. The data from 6 transplant centres were evaluated in order to identify significant variables associated with progression free survival (PFS) and overall survival (OS). Patients were transplanted between 1994 and 2005, the median age was 56 years, clinical stages according Durie-Salmon were as follows: stage I - 8 %, stage II - 29 %, stage III - 63 %. Transplantation was performed during the first year from diagnosis in 411 patients (83 %). The median follow-up from ASCT was 33.3 months. Transplant-related mortality to day +100 was 1 %, the median time to neutrophil engraftment was 12 days. The treatment responses after ASCT according to EBMT criteria were recorded in 149 patients (30 %), the complete response"@en . "Transfuze a hematologie dnes" .