. "RIV/00216208:11120/07:00001013" . "Virov\u00E1 infekce a s\u00E9rov\u00E9 protil\u00E1tky proti 'heat shock protein 70' v akutn\u00ED f\u00E1zi Meni\u00E9rovy choroby"@cs . "1"^^ . "Virov\u00E1 infekce a s\u00E9rov\u00E9 protil\u00E1tky proti 'heat shock protein 70' v akutn\u00ED f\u00E1zi Meni\u00E9rovy choroby"@cs . "Hahn, Ale\u0161" . "4"^^ . "S" . "Viral infection and serum antibodies to heat shock protein 70 in the acute phase of M\u00E9ni\u00E8re's disease" . "4"^^ . "anti heat shock protein 70 antibodies; autoantibodies; cytomegalovirus; herpes-virus; Meni\u00E9re's disease"@en . "Di Berardino, F." . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Meni\u00E8rova choroba je idiopatick\u00E9 nitrou\u0161n\u00ED onemocn\u011Bn\u00ED charakterizovan\u00E9 kol\u00EDsavou ztr\u00E1tou sluchu, ob\u010Dasn\u00FDm vertigem a tinnitem"@cs . "RIV/00216208:11120/07:00001013!RIV09-MSM-11120___" . "M\u00E9ni\u00E8re's disease (MD) is an idiopathic inner-ear disorder characterized by fluctuating hearing loss, episodic vertigo, and tinnitus. Though MD's etiology is unknown, growing evidence suggests that autoimmunity may be involved in its development. The aim of this prospective study was to investigate the presence of anti-heat shock protein 70 (anti-HSP70) antibodies during the acute phase of MD and to relate its presence to the antibody pattern. We examined the sera of 13 patients by Western blot immunoassays for reactivity to bovine inner-ear antigen (anti-HSP70) antibodies. The presence of viral antibodies and autoantibodies (herpes simplex, types 1, 2; herpes zoster; cytomegalovirus; Epstein-Barr; IgM; IgG; cardiolipin; thyroglobulin and thyroperoxidase; and antinuclear, antimitochondrial, and anti-smooth-cell antibodies) were also tested. We found reactivity to HSP70 in only 1 of the 13 MD patients (7.7%), and it occurred during herpes zoster reactivation. We found no relationship bet" . "Cesarani, A." . "Viral infection and serum antibodies to heat shock protein 70 in the acute phase of M\u00E9ni\u00E8re's disease"@en . . . "International Tinnitus Journal" . . "Alpini, D." . . "0946-5448" . "457957" . . . "13" . . "Viral infection and serum antibodies to heat shock protein 70 in the acute phase of M\u00E9ni\u00E8re's disease" . "11120" . "Viral infection and serum antibodies to heat shock protein 70 in the acute phase of M\u00E9ni\u00E8re's disease"@en . . "2" . . . "[31C38B20A625]" . . . . "M\u00E9ni\u00E8re's disease (MD) is an idiopathic inner-ear disorder characterized by fluctuating hearing loss, episodic vertigo, and tinnitus. Though MD's etiology is unknown, growing evidence suggests that autoimmunity may be involved in its development. The aim of this prospective study was to investigate the presence of anti-heat shock protein 70 (anti-HSP70) antibodies during the acute phase of MD and to relate its presence to the antibody pattern. We examined the sera of 13 patients by Western blot immunoassays for reactivity to bovine inner-ear antigen (anti-HSP70) antibodies. The presence of viral antibodies and autoantibodies (herpes simplex, types 1, 2; herpes zoster; cytomegalovirus; Epstein-Barr; IgM; IgG; cardiolipin; thyroglobulin and thyroperoxidase; and antinuclear, antimitochondrial, and anti-smooth-cell antibodies) were also tested. We found reactivity to HSP70 in only 1 of the 13 MD patients (7.7%), and it occurred during herpes zoster reactivation. We found no relationship bet"@en .