"Rapid loss of adoptively transferred tumor-specific CD8(+) T cells (T-CD8) following Ag recognition in the periphery and their limited accumulation within the tumor stroma reduces the effectiveness of T cell-based immunotherapy. To better understand the role of T-CD8 in the control of autochthonous tumors, we have used mice of the RIP1-Tag4 lineage that develop pancreatic beta cell tumors due to expression of the SV40 large T Ag from the rat insulin promoter. We previously showed that the kinetics of functional T-CD8 tolerance varies toward two distinct epitopes derived from T Ag. Epitope I ((206)SAINNYAQKL(215))-specific T-CD8 are rapidly deleted whereas T-CD8 targeting epitope IV (404VVYDFLKC411) persist over the lifetime of tumor-bearing animals. In this report, we show that the conditioning of tumor-bearing RIP1-Tag4 mice with agonistic anti-CD40 Ab induces extensive expansion of naive epitope I-specific TCR transgenic (TCR-I) T cells in this tolerogenic environment and delays their loss from the"@en . . . . "Auto\u0159i uv\u00E1d\u011Bj\u00ED, \u017Ee aplikace anti-CD40 protil\u00E1tky zvy\u0161uje imunitn\u00ED odpov\u011B\u010F na slab\u00E9 n\u00E1dorov\u00E9 antigeny"@cs . "1"^^ . . "Journal of Immunology" . "Knowles, B." . "Aplikace anti-CD40 protil\u00E1tky zvy\u0161uje imunitn\u00ED odpov\u011B\u010F na slab\u00E9 n\u00E1dorov\u00E9 antigeny"@cs . . "Tevethia, S." . "Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "0022-1767" . . "Aplikace anti-CD40 protil\u00E1tky zvy\u0161uje imunitn\u00ED odpov\u011B\u010F na slab\u00E9 n\u00E1dorov\u00E9 antigeny"@cs . . "Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors"@en . . "Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors" . "179" . . "V" . "410126" . "Rapid loss of adoptively transferred tumor-specific CD8(+) T cells (T-CD8) following Ag recognition in the periphery and their limited accumulation within the tumor stroma reduces the effectiveness of T cell-based immunotherapy. To better understand the role of T-CD8 in the control of autochthonous tumors, we have used mice of the RIP1-Tag4 lineage that develop pancreatic beta cell tumors due to expression of the SV40 large T Ag from the rat insulin promoter. We previously showed that the kinetics of functional T-CD8 tolerance varies toward two distinct epitopes derived from T Ag. Epitope I ((206)SAINNYAQKL(215))-specific T-CD8 are rapidly deleted whereas T-CD8 targeting epitope IV (404VVYDFLKC411) persist over the lifetime of tumor-bearing animals. In this report, we show that the conditioning of tumor-bearing RIP1-Tag4 mice with agonistic anti-CD40 Ab induces extensive expansion of naive epitope I-specific TCR transgenic (TCR-I) T cells in this tolerogenic environment and delays their loss from the" . "in-vivo ligation; transgenic mice; cross-presentation; cell tolerance; cutting edge; lymphocyte responses; endothelial-cells; effector function; dendritic cells; immune-system"@en . "RIV/00216208:11120/07:00000465!RIV08-MSM-11120___" . "Schell, T." . "11120" . . . "RIV/00216208:11120/07:00000465" . . . . "6686-6695" . . . . "Ot\u00E1hal, Pavel" . "10"^^ . . . "10" . "4"^^ . . "[1D0AAB43B379]" . . "Anti-CD40 conditioning enhances the T(CD8) response to a highly tolerogenic epitope and subsequent immunotherapy of simian virus 40 T antigen-induced pancreatic tumors"@en .